盐酸那可丁一水合物 | 219533-73-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 邻苯二甲酸异喹啉类
• 中文名称: 盐酸那可丁一水合物
• 英文名称: Noscapine hydrochloride hydrate
• 英文别名: (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one;hydrate;hydrochloride
• CAS: 219533-73-0
• 化学式: C22H26ClNO8
• 分子量: 467.9
• InChiKey: ZYGSNVAGWKWKKI-WCRQIBMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.48
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• IBUPROFEN-CONTAINING ORAL PHARMACEUTICAL FORMULATION
  申请人：SSP Co., Ltd.

  公开号：EP3880171A1

  公开（公告）日：2021-09-22
• [EN] IBUPROFEN-CONTAINING ORAL PHARMACEUTICAL FORMULATION<br/>[FR] FORMULATION PHARMACEUTIQUE ORALE CONTENANT DE L'IBUPROFÈNE
  申请人：SSP CO LTD

  公开号：WO2020101012A1

  公开（公告）日：2020-05-22

  The provision of technology for reducing the unpleasant taste of ibuprofen in ibuprofen-containing oral pharmaceutical formulations. An oral pharmaceutical formulation in which the unpleasant taste of ibuprofen is reduced, which contains (A) ibuprofen or salt thereof or solvate of these, and (B) magnesium oxide, wherein the mass ratio [(B)/(A)] of component (A) and component (B) is 0.2-1.5.
• [EN] SOLID PREPARATION CONTAINING IBUPROFEN<br/>[FR] PRÉPARATION SOLIDE CONTENANT DE L'IBUPROFÈNE
  申请人：[en]SSP CO., LTD.

  公开号：WO2022114240A1

  公开（公告）日：2022-06-02

  The disclosure provides a solid preparation having excellent dissolution of ibuprofen and a good color tone. The solid preparation includes a granular product containing the following ingredients (a1), (a2), (a3), and (a4): (a1) ibuprofen or a salt thereof or a solvate thereof; (a2) magnesium oxide; (a3) sodium lauryl sulfate; and (a4) one or more disintegrating agents selected from the group consisting of low substituted hydroxypropylcellulose, sodium carboxymethyl starch, carmellose, carmellose calcium, crospovidone, and croscarmellose sodium. The disclosure also provides methods of making such a solid preparation.