methylene di(cyclohexanecarboxylate)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methylene di(cyclohexanecarboxylate)
• 英文别名: (cyclohexanecarbonyloxy)methyl cyclohexanecarboxylate；Cyclohexanecarbonyloxymethyl cyclohexanecarboxylate
• 化学式: C₁₅H₂₄O₄
• 分子量: 268.353
• InChiKey: JINWIXAIPLQVCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二氯甲烷 、 环己甲酸 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 3.0h， 以99%的产率得到methylene di(cyclohexanecarboxylate)
  参考文献：
  名称：

  Synthesis of esters from aldehydes or carboxylic acids with dichloromethane, dichloroethane or dichloropropane under mild conditions

  摘要：

  二氯甲烷（DCM）作为C1来源的新发现：DCM与羧酸或醛在TBHP水溶液中高效合成了亚甲基双酯。这些反应在温和条件下进行，能够以优异至极佳的产率（高达>99%）得到脂肪族和芳香族亚甲基双酯。同样的方法，可以从1,2-二氯乙烷和1,3-二氯丙烷分别容易地获得良好的至极佳产率的2-氯乙基苯甲酸酯和3-氯丙基苯甲酸酯。

  DOI：

  10.1039/c3ra43615b

文献信息

• Dichloromethane as a methylene synthon for regioselective linkage of diverse carboxylic acids: Direct access to methylene diesters under metal-free conditions
  作者：Shuiliang Wang、Zhengjiang Fu、Zhicong Huang、Yongqing Jiang、Shengmei Guo、Hu Cai

  DOI：10.1016/j.cclet.2019.04.053

  日期：2019.6

  Abstract A metal-free cross coupling between common CH2Cl2 and carboxylic acids has been achieved with K2CO3 as the sole additive. This simple protocol is a convenient and cost-effective route to synthesize methylene diesters from a wide scope of carboxylic acids substrates with good functional group tolerance. Several gram-scale reactions have been performed to evaluate the effectiveness and practicality

  摘要以碳酸钾为唯一添加剂，实现了普通二氯甲烷与羧酸之间的无金属交叉偶联。这个简单的协议是从具有良好官能团耐受性的各种羧酸底物合成亚甲基二酯的便捷且经济高效的途径。已经进行了数克级的反应，以评估该协议的有效性和实用性。
• O-Fluoromethyl carboxylates and O-fluoromethyl carbamates
  作者：Manfred Schlosser、Dominique Limat

  DOI：10.1016/0040-4020(95)00251-3

  日期：1995.5

  The fluoride catalyzed reaction between acyl fluorides and monomeric formaldehyde affords fluoromethyl carboxylates in acceptable yields. - Fluoromethyl fluoroformate, readily accessible from the corresponding dichloro compound, condenses with amines to give fluoromethyl carbamates.

  酰基氟与单体甲醛之间的氟化物催化反应以可接受的收率提供了氟甲基羧酸盐。-可容易地从相应的二氯化合物获得的氟甲基氟甲酸酯与胺缩合以得到氟甲基氨基甲酸酯。
• Process for the synthesis of polyoxazolidinone compounds with high stability
  申请人：Covestro Deutschland AG

  公开号：US10385167B2

  公开（公告）日：2019-08-20

  The present invention relates to polyoxazolidinone compounds, a method for the production of polyoxazolidinone compounds, comprising the step of reacting a biscarbamate compound with a bisepoxide compound in the presence of a mono-carbamate, a mono-isocyanate and/or a mono-epoxide compound as chain regulator and a suitable base having a pKb value of ≤9 as catalyst. The invention further relates to the use of polyoxazolidinone compounds with high thermal stability.

  本发明涉及聚噁唑烷酮化合物，一种生产聚噁唑烷酮化合物的方法，包括以下步骤：在作为链调节剂的单氨基甲酸酯、单异氰酸酯和/或单环氧化物化合物以及作为催化剂的pKb值≤9的合适碱存在下，使双氨基甲酸酯化合物与双环氧化物化合物反应。本发明还涉及具有高热稳定性的聚恶唑烷酮化合物的用途。
• PROCESS FOR THE SYNTHESIS OF POLYOXAZOLIDINONE COMPOUNDS WITH HIGH STABILITY
  申请人：Covestro Deutschland AG

  公开号：EP3256508B1

  公开（公告）日：2019-03-27
• CELLULOSE ACYLATE FILM, RETARDATION FILM, POLARIZER AND LIQUID-CRYSTAL DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20140318413A1

  公开（公告）日：2014-10-30

  Provide is a cellulose acylate film, of which the environmental humidity-dependent retardation change is small and which, when stuck to a polarizer and used in high-temperature and high-humidity environments, is effective for preventing the polarizing element from being deteriorated. A cellulose acylate film, which contains a hydrogen-bonding compound satisfying the following requirements (A) to (C), and at least one hydrophobizing agent selected from a polyalcohol ester-base hydrophobizing agent, a polycondensate ester-base hydrophobizing agent and a carbohydrate derivative-base hydrophobizing agent: (A) the compound has both a hydrogen-bonding donor part and a hydrogen-bonding acceptor part in one molecule, (B) the value computed by dividing the molecular weight of the compound by the total number of the hydrogen-bonding donor number and the hydrogen-bonding acceptor number in the compound is from 30 to 65, and (C) the total number of the aromatic ring structures in the compound is from 1 to 3.