2-(2',4',5'-tribromo)-phenylethyl chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2',4',5'-tribromo)-phenylethyl chloride
• 英文别名: 1,2,4-Tribromo-5-(2-chloroethyl)benzene
• 化学式: C₈H₆Br₃Cl
• 分子量: 377.301
• InChiKey: RCLPHSMBQYITND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-(2',4',5'-tribromo)-phenylethyl chloride 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 72.0h， 生成 2-(2',4',5'-tribromo)-phenylethyl hydrazine
  参考文献：
  名称：

  Synthesis of the tritium labeled SCH 58261, a new non-xanthine A2A adenosine receptor antagonist

  摘要：

  The tritium labeled form of 5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo[4,3-e] 1,2,4-triazolo[1,5-c]pyrimidine (H-3-SCH 58261) was obtained by reduction of 5-amino-7-[2-(2',4',5'-tribromo)-phenylethyl]-2-(2-furyl)-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine with tritium gas in the presence of 10% Pd-C. Final product was purified by HPLC to give the title H-3-SCH 58261 with radiochemical purity of 99% and specific activity of 68.6 Ci/mmol. H-3-SCH 58261 bound A(2A) receptors in rat striatal membranes (specific binding > 90%) with K-d acid B-max value of 0.70 nM and 971 fmol/mg of protein, respectively. H-3-SCH 58261 represents a useful tool for a further characterization of A(2A) adenosine receptor subtype.

  DOI：

  10.1002/(sici)1099-1344(199608)38:8<725::aid-jlcr885>3.0.co;2-g
• 作为产物：
  描述：

  邻氯乙苯 在 溴 、 铁粉 作用下， 以 四氯化碳 为溶剂， 以70%的产率得到2-(2',4',5'-tribromo)-phenylethyl chloride
  参考文献：
  名称：

  Synthesis of the tritium labeled SCH 58261, a new non-xanthine A2A adenosine receptor antagonist

  摘要：

  The tritium labeled form of 5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo[4,3-e] 1,2,4-triazolo[1,5-c]pyrimidine (H-3-SCH 58261) was obtained by reduction of 5-amino-7-[2-(2',4',5'-tribromo)-phenylethyl]-2-(2-furyl)-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine with tritium gas in the presence of 10% Pd-C. Final product was purified by HPLC to give the title H-3-SCH 58261 with radiochemical purity of 99% and specific activity of 68.6 Ci/mmol. H-3-SCH 58261 bound A(2A) receptors in rat striatal membranes (specific binding > 90%) with K-d acid B-max value of 0.70 nM and 971 fmol/mg of protein, respectively. H-3-SCH 58261 represents a useful tool for a further characterization of A(2A) adenosine receptor subtype.

  DOI：

  10.1002/(sici)1099-1344(199608)38:8<725::aid-jlcr885>3.0.co;2-g

文献信息

• Synthesis of the tritium labeled SCH 58261, a new non-xanthine A2A adenosine receptor antagonist
  作者：Pier Giovanni Baraldi、Barbara Cacciari、Silvio Dionisotti、Judith Egan、Giampiero Spalluto、Cristina Zocchi

  DOI：10.1002/(sici)1099-1344(199608)38:8<725::aid-jlcr885>3.0.co;2-g

  日期：1996.8

  The tritium labeled form of 5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo[4,3-e] 1,2,4-triazolo[1,5-c]pyrimidine (H-3-SCH 58261) was obtained by reduction of 5-amino-7-[2-(2',4',5'-tribromo)-phenylethyl]-2-(2-furyl)-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine with tritium gas in the presence of 10% Pd-C. Final product was purified by HPLC to give the title H-3-SCH 58261 with radiochemical purity of 99% and specific activity of 68.6 Ci/mmol. H-3-SCH 58261 bound A(2A) receptors in rat striatal membranes (specific binding > 90%) with K-d acid B-max value of 0.70 nM and 971 fmol/mg of protein, respectively. H-3-SCH 58261 represents a useful tool for a further characterization of A(2A) adenosine receptor subtype.