Herein, we report studies leading to the discovery of the neoseptins and a comprehensive examination of the structure–activity relationships (SARs) of this new class of small-molecule mouse Toll-like receptor 4 (mTLR4) agonists. The compounds in this class, which emerged from screening an α-helix mimetic library, stimulate the immune response, act by a well-defined mechanism (mouse TLR4 agonist), are
在本文中,我们报道了导致新肽段的发现以及对这种新型小分子小鼠Toll样受体4(mTLR4)激动剂的结构-活性关系(
SAR)的全面研究的报告。该类化合物是通过筛选α-螺旋模拟物文库而产生的,可刺激免疫反应,并通过明确的机制发挥作用(小鼠TLR4激动剂),易于生产和结构操纵,具有精美的
SAR,无毒,与脂
多糖相比,即使它们共享相同的受体,也能引起改善的和质上不同的反应。