3-acetamidopropyl methacrylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-acetamidopropyl methacrylate
• 英文别名: 3-acetamidopropyl 2-methylprop-2-enoate
• 化学式: C₉H₁₅NO₃
• 分子量: 185.223
• InChiKey: VBFGSLUUXNMGAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(3-羟基丙基)乙酰胺 、 甲基丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到3-acetamidopropyl methacrylate
  参考文献：
  名称：

  双重可逆网络：通过Diels-Alder交联和氢键的结合改善混合材料的自愈

  摘要：

  固有的自我修复材料依赖于失效后可逆的键形成。在这项研究中，我们报告了包含两种固有的自我修复力的杂化材料：Diels–Alder基团的可逆共价键形成受到固有氢键的支持，后者形成超分子相互作用并有助于DA基团的迁移和接近。该概念是通过将含脲基的硅酸盐硅酸盐与同时带有DA部分和自组装氢键的甲基丙烯酸丁酯基聚合物相结合而实现的。合成了多功能单组分聚合物，并研究了它们在自修复杂化材料中的应用。根据IR，UV-vis，和CP-MAS NMR光谱。此外，进行了DSC和流变学测量，结果表明，与以前研究的系统相比，该材料在治疗能力方面具有优势。形成的杂化材料的自我修复行为通过使用显微镜图像进行的几毫米的切口愈合测试来证明。我们可以得出结论，将几种可逆功能结合在一种材料中以提高自愈能力是有利的，特别是在网络的灵活性受到限制的纳米复合材料中。形成的杂化材料的自我修复行为通过使用显微镜图像进行的几毫米的切口愈合测

  DOI：

  10.1021/acs.macromol.8b00601

文献信息

• Carboxamido (meth) acrylic acid esters for treatment of collagen
  申请人：Bayer Aktiengesellschaft

  公开号：US05300537A1

  公开（公告）日：1994-04-05

  For bonding dental fillings to dentine, carboxamide group-containing (meth)acrylic acid ester of the formula ##STR1## in which R.sup.1 denotes hydrogen or methyl, R.sup.2 denotes alkyl (C.sub.1 -C.sub.4) or alkenyl (C.sub.2 -C.sub.4), optionally substituted by hydroxyl, carboxyl, halogen or amino of the formula ##STR2## in which R.sup.4 and R.sup.5 are identical or different and denote hydrogen or lower alkyl, R.sup.3 denotes hydrogen or has one of the abovementioned meanings of R.sup.2 and X is a divalent aliphatic (C.sub.1 -C.sub.6) or cycloaliphatic radical (C.sub.3 -C.sub.6), which can optionally contain one or more oxygen, sulphur and/or --NR.sup.4 -bridges, where R.sup.4 has the abovementioned meaning.

  用于将牙齿填充物与牙本质粘合的含有卡box酰胺基的(甲基)丙烯酸酯的公式为##STR1##，其中R.sup.1表示氢或甲基，R.sup.2表示烷基(C.sub.1 -C.sub.4)或烯基(C.sub.2 -C.sub.4)，可选地由羟基、羧基、卤素或氨基取代的公式##STR2##，其中R.sup.4和R.sup.5相同或不同，表示氢或低烷基，R.sup.3表示氢或具有上述R.sup.2的任一含义，X是二价的脂肪族(C.sub.1 -C.sub.6)或环脂肪族(C.sub.3 -C.sub.6)，可选地含有一个或多个氧、硫和/或-NR.sup.4 -桥，其中R.sup.4具有上述含义。
• Dental composition, kit of parts and use thereof
  申请人：3M Innovative Properties Company

  公开号：EP2401998A1

  公开（公告）日：2012-01-04

  The invention relates to a dental composition comprising a) a compound (A) with the following features: only one backbone unit (U) with 6 to 20 carbon atoms, at least 6 carbon atoms thereof forming an aromatic or an aliphatic cyclic moiety, the remaining carbon atoms either being part of substituents pending from the cyclic moiety or being part of bridging groups to spacer units, wherein one or more of the remaining carbon atoms can be replaced by an oxygen atom, the backbone unit not comprising a bisphenol structure, one or two spacer unit(s) (S) being connected to the backbone unit (U) via an ether linkage, at least one spacer unit (S) comprising a -CH2-CH2-CH2-CH2-O-CH2-CH(Q)-OG chain or a -CH2-CH(OG)-CH2-OM residue or a mixture of these two types of spacers within one spacer unit, with G being connected to the spacer unit(s) (S) via an urethane moiety, each group G comprising at least one polymerizable moiety, and M comprising at least one group selected from acroyl, methacroyl, aryl, mixtures and combinations thereof, Q (not being connected to the spacer unit(s) (S) via an urethane moiety and) comprising at least one group selected from hydrogen, methyl, phenyl, phenoxymethyl, mixtures and combinations thereof, b) a filler (B) and c) an initiator (C).

  本发明涉及一种牙科组合物，包括 a) 具有以下特征的化合物 (A)：只有一个具有 6 至 20 个碳原子的骨架单元 (U)，其中至少有 6 个碳原子形成芳香族或脂肪族环状分子，其余碳原子或者是环状分子的取代基的一部分，或者是连接间隔单元的桥基的一部分，其中一个或多个其余碳原子可以被氧原子取代，骨架单元不包括双酚结构，一个或两个间隔单元 (S) 通过醚键连接到骨架单元 (U)、至少一个间隔单元（S）包含-CH2-CH2-CH2-CH2-O-CH2-CH(Q)-OG 链或-CH2-CH(OG)-CH2-OM 残基或一个间隔单元内这两种间隔单元的混合物，G 通过聚氨酯分子与间隔单元（S）连接，每个基团 G 包含至少一个可聚合分子、和 M 包括至少一个选自丙酰基、甲酰基、芳基、它们的混合物和组合的基团，Q（不通过氨基甲酸乙酯基团与间隔物单元（S）连接，并且）包括至少一个选自氢、甲基、苯基、苯氧甲基、它们的混合物和组合的基团，b）填料（B）和 c）引发剂（C）。
• Dental compositions comprising a fatty mono(meth)acrylate
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10022306B2

  公开（公告）日：2018-07-17

  Presently described are dental compositions comprising one or more fatty mono(meth)acrylates, methods of use, dental articles, and methods of making dental compositions. It has been found that a relatively low concentration of a fatty mono(meth)acrylate can improve the handling characteristics of a dental composition by reducing the tendency of the composition to stick to a dental instrument and/or by reducing the tendency of a dental composition to string when being manipulated by a dental instrument. In one embodiment, a hardenable dental composition is described comprising a polymerizable resin composition comprising at least one multifunctional ethylenically unsaturated monomer; 0.2 to 10 wt-% of one or more fatty mono(meth)acrylate monomers; and at least 50 wt-% of inorganic oxide filler.

  目前描述的是包含一种或多种脂肪单（甲基）丙烯酸酯的牙科组合物、使用方法、牙科用品和牙科组合物的制造方法。研究发现，相对低浓度的脂肪单（甲基）丙烯酸酯可以改善牙科组合物的操作特性，降低组合物粘附在牙科器械上的倾向和/或降低牙科组合物在牙科器械操作时串连的倾向。在一个实施方案中，描述了一种可硬化牙科组合物，该组合物包含一种可聚合树脂组合物，该树脂组合物包含至少一种多功能乙烯基不饱和单体；0.2-10 wt-%的一种或多种脂肪单（甲基）丙烯酸酯单体；以及至少 50 wt-%的无机氧化物填料。
• Dental compositions comprising nanoparticles providing a refractive index differential between polymerizable resin and filler
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US11246808B2

  公开（公告）日：2022-02-15

  Dental compositions and methods of formulating a dental composition are described. In one embodiment, the dental composition comprises a polymerizable resin comprising one or more ethylenically unsaturated monomers or oligomers and nano-particles. The nanoparticles have a refractive index of at least 1.600 and an average discrete or aggregate particle size of no greater than 100 nm. The dental composition further comprises inorganic metal oxide filler having a discrete or aggregate average particle size of at least 200 nm. The nanoparticles are present at a concentration to provide a refractive index differential between the cured polymerizable resin and inorganic metal oxide filler such that the contrast ratio of the dental composition is at least 40.

  本文描述了牙科组合物和配制牙科组合物的方法。在一个实施方案中，牙科组合物包括由一种或多种乙烯基不饱和单体或低聚物和纳米颗粒组成的可聚合树脂。纳米颗粒的折射率至少为 1.600，平均离散或聚合粒径不大于 100 纳米。牙科组合物还包括无机金属氧化物填料，其离散或聚集平均粒径至少为 200 纳米。纳米颗粒的存在浓度可使固化的可聚合树脂和无机金属氧化物填料之间的折射率差达到牙科组合物的对比度至少为 40。
• COVALENTLY BONDING NAIL PRIMER
  申请人：Schoon Douglas D.

  公开号：US20080226573A1

  公开（公告）日：2008-09-18

  The present invention relates generally to the field of primers and adhesion promoters. More specifically, the primer of the present invention is comprised of one or more multi-carbonylated methacrylates. In a preferred embodiment, a non-ketone polar solvent is also employee. The resulting composition eliminates primer related discoloration of artificial nail enhancements, eliminates the potential for corrosion of skin and nails, and eliminates risk of chemical burn injury, while providing stronger adhesion than currently available primers.