2-(4-chlorobenzyl)-7,9-dioxaspiro[4,5]decan-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-chlorobenzyl)-7,9-dioxaspiro[4,5]decan-1-one
• 英文别名: 2-(4-Chlorobenzyl)-7,9-dioxaspiro[4.5]decan-1-one；3-[(4-chlorophenyl)methyl]-7,9-dioxaspiro[4.5]decan-4-one
• 化学式: C₁₅H₁₇ClO₃
• 分子量: 280.751
• InChiKey: UQPKDCMRJBEZMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-chlorobenzyl)-3,3-bis(hydroxymethyl)-2-oxocyclopentane carboxylic acid methyl ester 在 对甲苯磺酸 作用下， 以 水 、 甲苯 为溶剂， 反应 18.5h， 生成 2-(4-chlorobenzyl)-7,9-dioxaspiro[4,5]decan-1-one
  参考文献：
  名称：

  EP2927220

  摘要：

  公开号：

文献信息

• PRODUCTION METHOD OF CARBONYL COMPOUND
  申请人：KUREHA CORPORATION

  公开号：US20150299080A1

  公开（公告）日：2015-10-22

  The present invention is to provide a method of producing a carbonyl compound at a higher yield. The method of producing a carbonyl compound according to the present invention produces a carbonyl compound represented by general formula (I) by subjecting a compound represented by general formula (II) to dealkoxycarbonylation in the presence of a hydrogen halide salt of tertiary amine. In the formula, R represents an alkyl group having from 1 to 4 carbons.

  本发明提供了一种以更高产率生产酮基化合物的方法。根据本发明的生产酮基化合物的方法通过在三级胺的氢卤化盐存在下，使通式（II）表示的化合物经脱烷氧羰化反应产生通式（I）表示的酮基化合物。在该式中，R代表具有1至4个碳原子的烷基基团。
• Production method of carbonyl compound
  申请人：Kureha Corporation

  公开号：US09206106B2

  公开（公告）日：2015-12-08

  The present invention is to provide a method of producing a carbonyl compound at a higher yield. The method of producing a carbonyl compound according to the present invention produces a carbonyl compound represented by general formula (I) by subjecting a compound represented by general formula (II) to dealkoxycarbonylation in the presence of a hydrogen halide salt of tertiary amine. In the formula, R represents an alkyl group having from 1 to 4 carbons.

  本发明提供了一种以更高的产率生产羰基化合物的方法。根据本发明的羰基化合物的生产方法，在三级胺的氢卤化盐的存在下，通过将通式（II）化合物进行去烷氧羰基化反应，可以生产通式（I）表示的羰基化合物。在公式中，R代表具有1至4个碳的烷基基团。
• PRODUCTION METHOD FOR CARBONYL COMPOUND
  申请人：Kureha Corporation

  公开号：EP2927207A1

  公开（公告）日：2015-10-07

  The present invention is to provide a method of producing a carbonyl compound at a higher yield. The method of producing a carbonyl compound according to the present invention produces a carbonyl compound represented by general formula (I) by subjecting a compound represented by general formula (II) to dealkoxycarbonylation in the presence of a hydrogen halide salt of tertiary amine. In the formula, R represents an alkyl group having from 1 to 4 carbons.

  本发明旨在提供一种以较高产率生产羰基化合物的方法。根据本发明生产羰基化合物的方法，在叔胺的卤化氢盐存在下，将通式（II）代表的化合物进行脱烷氧基羰基化反应，生产通式（I）代表的羰基化合物。 式中，R 代表具有 1 至 4 个碳原子的烷基。
• METHOD FOR PRODUCING CYCLOPENTANONE DERIVATIVE, INTERMEDIATE COMPOUND, AND METHOD FOR PRODUCING INTERMEDIATE COMPOUND
  申请人：Kureha Corporation

  公开号：EP2927220A1

  公开（公告）日：2015-10-07

  A method for producing a cyclopentanone derivative represented by general formula (III) below, wherein a cyclopentanone derivative represented by general formula (III) below can be produced with higher yield since the method comprises a step in which a compound represented by general formula (II) below is obtained by reacting a compound represented by general formula (I) below with an acid.

  一种生产下式通式(III)所代表的环戊酮衍生物的方法，其中下式通式(III)所代表的环戊酮衍生物可以更高的产率生产，因为该方法包括一个步骤，在该步骤中，下式通式(II)所代表的化合物是通过下式通式(I)所代表的化合物与酸反应而得到的。
• AZOLE DERIVATIVE, METHOD FOR PRODUCING AZOLE DERIVATIVE, AND INTERMEDIATE COMPOUND
  申请人：Kureha Corporation

  公开号：EP2719695B1

  公开（公告）日：2016-05-18