6-propionyl-2-(dihexylamino)anthracene

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 6-propionyl-2-(dihexylamino)anthracene
• 英文别名: Anthradan；1-[6-(dihexylamino)anthracen-2-yl]propan-1-one
• 化学式: C₂₉H₃₉NO
• 分子量: 417.635
• InChiKey: IGGBMFJKMZGBPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-二溴蒽醌 在 copper(l) chloride sodium tetrahydroborate 、 potassium carbonate 作用下， 以 四氢呋喃 、 二甲基亚砜 、 N,N-二甲基甲酰胺 、 异丙醇 为溶剂， 反应 62.0h， 生成 6-propionyl-2-(dihexylamino)anthracene
  参考文献：
  名称：

  Long-Wavelength Analogue of PRODAN:  Synthesis and Properties of Anthradan, a Fluorophore with a 2,6-Donor−Acceptor Anthracene Structure

  摘要：

  We have synthesized the environment-sensitive fluorophores 2-cyano-6-dihexylaminoanthracene and 2-propionyl-6-dihexylaminoanthracene (Anthradan) starting from 2,6-diaminoanthraquinone. Anthradan is the benzologue of the well-known family of naphthalene 2-propionyl-6-dimethylaminonaphthalene (PRODAN) fluorophores. The additional spectral red shift of the anthracene avoids the autofluorescence of many biological systems and provides for more favorable excitation wavelengths for fluorescence applications. Furthermore, Anthradan exhibits polarity-sensitive emission comparable to that of PRODAN and displays high quantum yields in a range of solvents. Single molecules of these anthracene-containing fluorophores have been imaged in polymer hosts as a proof-of-principle.

  DOI：

  10.1021/jo0616660

文献信息

• Glucose biosensors and uses thereof
  申请人：Duke University

  公开号：US11156615B2

  公开（公告）日：2021-10-26

  The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.

  本主题提供了葡萄糖生物传感器以及包含此类生物传感器的组合物、装置和方法。
• Thermostable glucose biosensors and uses thereof
  申请人：Duke University

  公开号：US11402384B2

  公开（公告）日：2022-08-02

  The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.

  本主题提供了葡萄糖生物传感器以及包含此类生物传感器的组合物、装置和方法。
• GLUCOSE BIOSENSORS AND USES THEREOF
  申请人：Duke University

  公开号：EP3377643A1

  公开（公告）日：2018-09-26
• LACTATE BIOSENSORS AND USES THEREOF
  申请人：Duke University

  公开号：EP3377897A1

  公开（公告）日：2018-09-26
• THERMOSTABLE GLUCOSE BIOSENSORS AND USES THEREOF
  申请人：Duke University

  公开号：EP3377898A2

  公开（公告）日：2018-09-26