二甲基氨基二硫代甲酸铅 | 19010-66-3

• 分子结构分类: 有机化合物 - 有机硫化合物
• 中文名称: 二甲基氨基二硫代甲酸铅
• 中文别名: 福美铅
• 英文名称: Lead dimethyldithiocarbamate
• 英文别名: bis(dimethylcarbamothioylsulfanyl)lead
• CAS: 19010-66-3
• 化学式: C₆H₁₂N₂PbS₄
• 分子量: 447.639
• InChiKey: QGTHALAWFUFVCU-UHFFFAOYSA-L

物化性质

• 熔点：
  284°C
• 密度：
  2.43 g/cm3
• 物理描述：
  Lead dimethyldithiocarbamate is a white to off-white powder. (NTP, 1992)
• 颜色/状态：
  White powder
• 溶解度：
  Less than 0.1 mg/mL water at 73 °F (23 °C)
• 分解：
  When heated to decomposition, it emits very toxic fumes of /lead, nitrogen oxides and sulfur oxides/.

计算性质

• 辛醇/水分配系数(LogP)：
  0.38
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  72.7
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 毒性总结

识别和使用：铅二甲基二硫代氨基甲酸盐是一种白色粉末。它用作橡胶加工工业中高速、高温硫化反应的加速剂。它用于配制天然、苯乙烯-丁二烯、异丁烯-异戊二烯、异戊二烯和丁二烯橡胶。在连续固化条件下有效，通常与噻唑改性剂一起使用。人体暴露和毒性：无数据可用。动物研究：对技术级铅二甲基二硫代氨基甲酸盐进行了可能的致癌性生物分析，通过将测试化学品掺入饲料中给大鼠和小鼠服用。每组50只雄性和50只雌性大鼠以及50只雄性和50只雌性小鼠分别以25或50 ppm的剂量服用铅二甲基二硫代氨基甲酸盐，持续104或105周。对照组包括每组20只未处理的雄性和20只未处理的雌性大鼠以及小鼠。结论是在这个生物分析的条件下，铅二甲基二硫代氨基甲酸盐对大鼠或小鼠的任一性别均不具致癌性。

IDENTIFICATION AND USE: Lead dimethyldithiocarbamate is a white powder. It is used in rubber processing industry as accelerator for high speed, high temp vulcanization. It is used in compounding natural, styrene-butadiene, isobutylene-isoprene, isoprene and butadiene rubbers. It is effective under continuous curing conditions and is generally used with thiazole modifiers. HUMAN EXPOSURE AND TOXICITY: There are no data available. ANIMAL STUDIES: A bioassay of technical grade lead dimethyldithiocarbamate for possible carcinogenicity was conducted by administering the test chemical in feed to rats and mice. Groups of 50 rats of each sex and 50 mice of each sex were administered lead dimethyldithiocarbamate at one of the two doses, either 25 or 50 ppm, for 104 or 105 weeks. Matched controls consisted of 20 untreated rats and 20 untreated mice of each sex. It is concluded that under the conditions of this bioassay, lead dimethyldithiocarbamate was not carcinogenic for rats or mice of either sex.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

无机铅化合物的致癌性在人类中的证据有限。...在实验动物中，有足够的证据表明无机铅化合物具有致癌性。在实验动物中，有足够的证据表明醋酸铅、亚醋酸铅、铬酸铅和磷酸铅具有致癌性。在实验动物中，对于氧化铅和砷酸铅的致癌性证据不足。...在实验动物中，对于铅粉的致癌性证据不足。总体评估无机铅化合物可能对人类具有致癌性（2A组）。/无机铅化合物/

There is limited evidence in humans for the carcinogenicity of inorganic lead compounds. ... There is sufficient evidence in experimental animals for the carcinogenicity of inorganic lead compounds. There is sufficient evidence in experimental animals for the carcinogenicity of lead acetate, lead subacetate, lead chromate, and lead phosphate. There is inadequate evidence in experimental animals for the carcinogenicity of lead oxide and lead arsenate. ... There is inadequate evidence in experimental animals for the carcinogenicity of lead powder. Overall evaluation Inorganic lead compounds are probably carcinogenic to humans (Group 2A). /Inorganic lead compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

分类：B2；可能的人类致癌物。分类依据：充分的动物证据。十项大鼠生物测试和一项小鼠测试显示，通过饮食和皮下接触几种可溶性铅盐，肾肿瘤统计学上显著增加。动物测试在多个实验室、多种大鼠品系中提供了可重复的结果，并有部分多肿瘤位点的证据。短期研究表明铅影响基因表达。人类致癌性数据不足。人类致癌性数据：不足。动物致癌性数据：充分。/基于以前分类系统的铅和化合物（无机）/

CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Sufficient animal evidence. Ten rat bioassays and one mouse assay have shown statisticlly significant increases in renal tumors with dietary and subcutaneous exposure to several soluble lead salts. Animal assays provide reproducible results in several laboratories, in multiple rat strains with some evidence of multiple tumor sites. Short term studies show that lead affects gene expression. Human evidence is inadequate. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Sufficient. /Lead and Compounds (inorganic), Based on former classification system/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A3; 已确认的动物致癌物，对人类的相关性未知。/铅和铅的无机化合物，如 Pb/

A3; Confirmed animal carcinogen with unknown relevance to humans. /Lead and and inorganic compounds, as Pb/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

铅及其化合物基于有限的人类致癌性研究和充分的实验动物致癌性研究，合理预期为人类致癌物。

Lead and lead compounds are reasonably anticipated to be human carcinogens based on limited evidence of carcinogenicity from studies in humans and sufficient evidence of carcinogenicity from studies in experimental animals. /Lead and Lead compounds/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2930909090

制备方法与用途

类别：有毒物质

可燃性危险特性：

• 可燃
• 火场排出含铅和硫氧化物、氮氧化物及辛辣刺激烟雾

储运特性：

• 库房低温、通风、干燥

灭火剂：

• 水
• 二氧化碳
• 干粉
• 砂土

反应信息

• 作为产物：
  描述：

  lead 、 福美双 在 (Et₄N)(ClO₄) 作用下， 以 丙酮 为溶剂， 以69%的产率得到二甲基氨基二硫代甲酸铅
  参考文献：
  名称：

  The electrochemical synthesis of O-ethylxanthato and N,N′-dimethyldithiocarbamato complexes of indium(III), tin(IV), lead(II), bismuth(III) and tellurium(IV)

  摘要：

  DOI：

  10.1016/s0020-1693(00)96023-7

文献信息

• Ecotoxicity assessment of sodium dimethyldithiocarbamate and its micro-sized metal chelates in Caenorhabditis elegans
  作者：Yitian Wang、Han Zhang、Xiangyu Wu、Cheng Xue、Yang Hu、Asim Khan、Fuwen Liu、Lankun Cai

  DOI：10.1016/j.scitotenv.2020.137666

  日期：2020.6

  dimethyldithiocarbamate (SDDC) is a widely used heavy metal chelating agent in harmless treatment of wastewater and hazardous waste, but SDDC and its heavy metal chelates may leak into the environment and bring potential ecological risks. In this study, the model organism Caenorhabditis elegans was used to evaluate the toxic effect of SDDC and its heavy metal Cu, Pb chelates. Multiple endpoints were investigated by

  二甲基二硫代氨基甲酸钠（SDDC）是无害处理废水和危险废物中广泛使用的重金属螯合剂，但SDDC及其重金属螯合物可能泄漏到环境中并带来潜在的生态风险。在这项研究中，模型生物秀丽隐杆线虫被用于评估SDDC及其重金属Cu，Pb螯合物的毒性作用。通过亚急性暴露于SDDC（0.01-100 mg / L）和SDDC的微米尺寸Cu，Pb螯合物（1-100 mg / L）来研究多个终点。我们的数据表明SDDC的LC50值为139.39 mg / L（95％Cl：111.03，174.75 mg / L）。此外，SDDC还发现线虫秀丽线虫的安全限值为1 mg / L，而浓度超过1 mg / L会对线虫的存活，生长产生不利影响，裸露线虫的运动行为和活性氧（ROS）的产生。此外，所有测试的SDDC-Cu和SDDC-Pb螯合物的毒性作用均明显低于未处理的Cu，Pb金属。由于其更稳定的结构，这两种螯合物还具有比S

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