(R)-(-)-N-2-ethylhexylpentanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-(-)-N-2-ethylhexylpentanamide
• 英文别名: N-[(2R)-2-ethylhexyl]pentanamide
• 化学式: C₁₃H₂₇NO
• 分子量: 213.363
• InChiKey: DDCHZGHPXAAQOZ-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-乙基己胺 、 正戊酸 在 Candida antarctica lipase 作用下， 反应 12.0h， 以91%的产率得到(R)-(-)-N-2-ethylhexylpentanamide
  参考文献：
  名称：

  Solvent-free biocatalytic amidation of carboxylic acids

  摘要：

  Lipase-catalyzed enantioselective amidation was performed by reacting the racemic amine with aliphatic acids in nonsolvent system. The reaction equilibrium was shifted towards amide synthesis by the removal of water under reduced pressure. This methodology avoids the use of activating agents and hazardous solvents. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.04.121

文献信息

• Solvent-free biocatalytic amidation of carboxylic acids
  作者：Ashok K. Prasad、Mofazzal Husain、Brajendra K. Singh、Rajinder K. Gupta、Vijay K. Manchanda、Carl E. Olsen、Virinder S. Parmar

  DOI：10.1016/j.tetlet.2005.04.121

  日期：2005.6

  Lipase-catalyzed enantioselective amidation was performed by reacting the racemic amine with aliphatic acids in nonsolvent system. The reaction equilibrium was shifted towards amide synthesis by the removal of water under reduced pressure. This methodology avoids the use of activating agents and hazardous solvents. (c) 2005 Elsevier Ltd. All rights reserved.