1-(1,7-dimethyl-1H-indol-3-yl)-2-phenylethane-1,2-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(1,7-dimethyl-1H-indol-3-yl)-2-phenylethane-1,2-dione
• 英文别名: 1-(1,7-Dimethylindol-3-yl)-2-phenylethane-1,2-dione；1-(1,7-dimethylindol-3-yl)-2-phenylethane-1,2-dione
• 化学式: C₁₈H₁₅NO₂
• 分子量: 277.323
• InChiKey: MUPIWKQGINBSMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  39.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,7-二甲基-1H-吲哚 、 苯基丙醇水合物 在 吡啶 、 copper(I) bromide 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以89%的产率得到1-(1,7-dimethyl-1H-indol-3-yl)-2-phenylethane-1,2-dione
  参考文献：
  名称：

  Copper-catalyzed aerobic oxidative dicarbonylation of indoles utilizing α-carbonyl aldehydes

  摘要：

  An efficient and practical protocol for copper-catalyzed aerobic oxidative dicarbonylation of indoles using cc-carbonyl aldehydes to construct C-3 indole-substituted 1,2-diketones is developed. Various C-3 indole-substituted 1,2-diketones were observed in good to excellent yields under mild reaction conditions. This transformation used air as an ideal oxidant and produced water as the only by-product. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.07.004

文献信息

• Copper-catalyzed aerobic oxidative dicarbonylation of indoles utilizing α-carbonyl aldehydes
  作者：Jin-Ming Yang、Zhong-Jian Cai、Qing-Dong Wang、Dong Fang、Shun-Jun Ji

  DOI：10.1016/j.tet.2015.07.004

  日期：2015.9

  An efficient and practical protocol for copper-catalyzed aerobic oxidative dicarbonylation of indoles using cc-carbonyl aldehydes to construct C-3 indole-substituted 1,2-diketones is developed. Various C-3 indole-substituted 1,2-diketones were observed in good to excellent yields under mild reaction conditions. This transformation used air as an ideal oxidant and produced water as the only by-product. (C) 2015 Elsevier Ltd. All rights reserved.