potassium 5-hydroxypentanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: potassium 5-hydroxypentanoate
• 英文别名: potassium;5-hydroxypentanoate
• 化学式: C₅H₉O₃*K
• 分子量: 156.223
• InChiKey: GBPZHPFBKPQHKT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  potassium 5-hydroxypentanoate 在 硫酸 、 sodium bromide 作用下， 以 水 为溶剂， 反应 8.0h， 以88.9%的产率得到5-溴戊酸
  参考文献：
  名称：

  一种5-溴戊酸的制备方法

  摘要：

  本发明涉及一种5‑溴戊酸的制备方法，具体方法是5‑氯‑3‑戊烯酸酯经过水解反应、氢化反应和溴代反应三步制得，所述5‑氯‑3‑戊烯酸酯为5‑氯‑3‑戊烯酸甲酯、5‑氯‑3‑戊烯酸乙酯、5‑氯‑3‑戊烯酸丙酯、5‑氯‑3‑戊烯酸丁酯之中的一种或多种。本发明制备方法成品收率高、生产成本低、简单易控，易于工业化生产，同时避免使用苯、氰化钠等高毒性物质，安全性高。

  公开号：

  CN105712864B
• 作为产物：
  描述：

  delta-戊内酯 在 potassium hydroxide 作用下， 以 水 为溶剂， 反应 3.0h， 以94%的产率得到potassium 5-hydroxypentanoate
  参考文献：
  名称：

  Specificity of extended O-aryloxycarbonyl hydroxamates as inhibitors of a class C β-lactamase

  摘要：

  Class C beta-lactamases have previously been shown to be efficiently inactivated by O-aryloxycarbonyl hydroxamates. O-Phenoxycarbonyl-N-benzyloxycarbonylhydroxylamine (1) and O-phenoxycarbonyl-N-(R)-[(4-amino4- carboxy-1-butyl) oxycarbonyl] hydroxylamine (2), for example, were found to be effective inactivators. The present paper describes a structure-activity study of these molecules to better define the important structural elements for high inhibitory activity. The results show that a well-positioned hydrophobic element (which may interact with the Tyr221 residue of the enzyme) and a negatively charged element, e. g. a carboxylate group (which may interact with Arg204), are required for high reactivity with the enzyme. The new compounds were found to inactivate by forming a carbonyl cross-linked enzyme (probably Ser64OCONHLys 315) as for 1 rather than the inert hydroxamoyl derivative observed with 2.

  DOI：

  10.1016/j.bmc.2019.02.023

文献信息

• Isomerization of Unprotected Aldoses to 2-Deoxyaldonic Acids Induced by Visible Light/Quinuclidine/Water-Soluble Iridium Complex in Water
  作者：Yusuke Masuda、Hiromu Tsuda、Masahiro Murakami

  DOI：10.1246/bcsj.20210098

  日期：——

  We herein report that a visible light/quinuclidine/water-soluble iridium complex system is highly effective for promoting the isomerization reaction of aldoses to 2-deoxyaldonic acids in water. The product yields and functional group compatibility are much better than those observed with a UV light/water-soluble benzophenone system.

  我们在此报告，可见光/奎宁环/水溶性铱络合物体系对于促进醛酸在水中的异构化反应非常有效。与紫外光/水溶性二苯甲酮体系相比，该体系的产物产率和官能团相容性都要好得多。
• Specificity of extended O-aryloxycarbonyl hydroxamates as inhibitors of a class C β-lactamase
  作者：Alexandra A. Malico、K. Dave、S.A. Adediran、R.F. Pratt

  DOI：10.1016/j.bmc.2019.02.023

  日期：2019.4

  Class C beta-lactamases have previously been shown to be efficiently inactivated by O-aryloxycarbonyl hydroxamates. O-Phenoxycarbonyl-N-benzyloxycarbonylhydroxylamine (1) and O-phenoxycarbonyl-N-(R)-[(4-amino4- carboxy-1-butyl) oxycarbonyl] hydroxylamine (2), for example, were found to be effective inactivators. The present paper describes a structure-activity study of these molecules to better define the important structural elements for high inhibitory activity. The results show that a well-positioned hydrophobic element (which may interact with the Tyr221 residue of the enzyme) and a negatively charged element, e. g. a carboxylate group (which may interact with Arg204), are required for high reactivity with the enzyme. The new compounds were found to inactivate by forming a carbonyl cross-linked enzyme (probably Ser64OCONHLys 315) as for 1 rather than the inert hydroxamoyl derivative observed with 2.
• 一种5-溴戊酸的制备方法
  申请人：湖北相和精密化学有限公司

  公开号：CN105712864B

  公开（公告）日：2017-12-08

  本发明涉及一种5‑溴戊酸的制备方法，具体方法是5‑氯‑3‑戊烯酸酯经过水解反应、氢化反应和溴代反应三步制得，所述5‑氯‑3‑戊烯酸酯为5‑氯‑3‑戊烯酸甲酯、5‑氯‑3‑戊烯酸乙酯、5‑氯‑3‑戊烯酸丙酯、5‑氯‑3‑戊烯酸丁酯之中的一种或多种。本发明制备方法成品收率高、生产成本低、简单易控，易于工业化生产，同时避免使用苯、氰化钠等高毒性物质，安全性高。