二甲基苯甲基-2-甲基丙烯酸乙胺酯溴化物 | 157617-92-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 二甲基苯甲基-2-甲基丙烯酸乙胺酯溴化物
• 英文名称: N-benzyl-2-(methacryloyloxy)-N,N-dimethylethanaminium bromide
• 英文别名: N,N-dimethyl-N-benzyl-N-(2-methacryloyloxyethyl)ammonium bromide；Benzyl-dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;bromide
• CAS: 157617-92-0
• 化学式: Br*C₁₅H₂₂NO₂
• 分子量: 328.249
• InChiKey: AJVIGYSWIQOVGW-UHFFFAOYSA-M

物化性质

• 熔点：
  146 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.61
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二甲基苯甲基-2-甲基丙烯酸乙胺酯溴化物 、 ketoprofen sodium 以 氯仿 为溶剂， 反应 2.0h， 以100%的产率得到N,N-dimethyl-N-benzyl-N-(2-methacryloyloxyethyl)ammonium ketoprofenate
  参考文献：
  名称：

  含有双重生物活性离子的聚合物系统

  摘要：

  本文报道了与非甾体类抗炎药（NSAIDs）离子连接的含季铵阳离子的双功能可聚合盐的合成和表征，以及它们的聚合物和由不同亲水性的丙烯酸单体（例如甲基丙烯酸甲酯和2-羟乙基）制得的共聚体系。甲基丙烯酸酯。使用的非甾体抗炎药是甲氯芬那酸，酮洛芬和布洛芬。在10天的时间内观察到了NSAID从聚合物和共聚样品中的持续释放，并且聚合物系统和药物的疏水性/亲水性都在释放行为中起作用。证实了双功能单体和聚合衍生物对革兰氏阳性和革兰氏阴性细菌的抗菌活性，并且聚合化合物具有比前代单体更高的杀菌作用。共聚样品的提取物在一氧化氮抑制试验中对RAW 264.7细胞具有抗炎活性，并且在前7天内产生约80％的NO抑制作用。

  DOI：

  10.1016/j.ejmech.2011.08.004
• 作为产物：
  描述：

  甲基丙烯酸二甲氨乙酯 、 溴甲苯 以 四氢呋喃 为溶剂， 反应 0.33h， 以95%的产率得到二甲基苯甲基-2-甲基丙烯酸乙胺酯溴化物
  参考文献：
  名称：

  Lipase-immobilized magnetic chitosan nanoparticles for kinetic resolution of (R,S)-ibuprofen

  摘要：

  Chitosan (CS)-poly[N-benzyl-2-(methacryloxy)-N,N-dimethylethanaminium bromide] coated magnetic nanoparticles were prepared by co-precipitation method via epichlorohydrin CS cross-linking reaction and were used in the kinetic resolution of (R,S)-ibuprofen by enantioselective esterification. Enzyme immobilized onto the surface of the new magnetic supports with the use of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/N-hydroxysulfo-succinimide sodium salt (sulfo-NHS) procedure demonstrated high catalytic activity that enabled us to obtain (S)-methyl ester of ibuprofen with high enantioselectivity (E = 50.6). The chiral compounds that resulted from the application of magnetic nanoparticles were analyzed with the use of chiral stationary phases. It should be emphasized that the main advantage of the support is the possibility to magnetically recovery and effective separation (even up to 5 s) from the reaction mixture with the use of magnet. The properties of magnetic particles allow for better optimization and may reduce the total costs of the esterification reaction of ibuprofen. Moreover, the application of lipase-immobilized magnetic supports enables to maintain high enantioselective activity after repeated use. (c) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2013.04.008
• 作为试剂：
  描述：

  4-碘代苯乙酮 、 sodium methansulfinate 在 copper(l) iodide 、 二甲基苯甲基-2-甲基丙烯酸乙胺酯溴化物 、 caesium carbonate 作用下， 以 氯苯 为溶剂， 反应 24.0h， 以94.9%的产率得到4-甲砜基苯乙酮
  参考文献：
  名称：

  一种4-甲磺酰基苯乙酮及α-溴-4-甲磺酰基苯 乙酮的制备方法

  摘要：

  本发明公开了一种4‑甲磺酰基苯乙酮及α‑溴‑4‑甲磺酰基苯乙酮的制备方法，4‑甲磺酰基苯乙酮的制备：在无机碱、催化剂和烯酯基季铵盐的共同存在下使4‑碘代苯乙酮和甲磺酸盐在溶剂中反应，生成4‑甲磺酰基苯乙酮；α‑溴‑4‑甲磺酰基苯乙酮的制备：使前述制备的4‑甲磺酰基苯乙酮与溴在溶剂中、在温度30‑40℃下反应，即得；本发明的制备方法能够得到更为理想的产物收率，且三废较少，适于工业化大规模生产。

  公开号：

  CN109134318B

文献信息

• METHOD FOR PRODUCING ORGANIC TELLURIUM COMPOUND AND METHOD FOR PRODUCING VINYL POLYMER
  申请人：OTSUKA CHEMICAL CO., LTD

  公开号：US20220009885A1

  公开（公告）日：2022-01-13

  Provided is a method for producing an organic tellurium compound that enables the production of an organic tellurium compound in high yield using metallic tellurium as a source material and produces less amount of side products. A method for producing an organic tellurium compound includes the steps of: (A) reacting metallic tellurium with a compound represented by a general formula (1) below; and (B) reacting a compound obtained by the step (A) with an organic halogen compound, the metallic tellurium having a copper content of less than 100 ppm, M(R 1 )m   Formula (1) where R 1 represents an alkyl group having 1 to 8 carbon atoms, an aryl group or an aromatic heterocyclic group, M represents an alkali metal or an alkaline earth metal, m represents 1 when M is an alkali metal, and m represents 2 when M is an alkaline earth metal.

  提供了一种制备有机碲化合物的方法，该方法使用金属碲作为原材料，使得有机碲化合物的产率高且产生的副产物较少。制备有机碲化合物的方法包括以下步骤：(A)将金属碲与下面通式(1)所代表的化合物反应；(B)将由步骤(A)得到的化合物与有机卤化合物反应，其中金属碲中铜的含量小于100 ppm，M(R1)m  式(1)，其中R1代表1至8个碳原子的烷基、芳基或芳香族杂环基，M代表碱金属或碱土金属，当M为碱金属时，m为1，当M为碱土金属时，m为2。
• NOVEL COPOLYMER
  申请人：Nippon Soda Co., Ltd.

  公开号：EP2589614A1

  公开（公告）日：2013-05-08

  An object of the present invention is to provide a novel copolymer useful as a dispersing agent for a pigment or the like. The novel copolymer contains: a block chain (A) comprising at least one repeating unit selected from the group consisting of a repeating unit having a tertiary amino group and a repeating unit having a quaternary ammonium salt group; and a block chain (B) comprising a repeating unit having an acidic group and a repeating unit represented by the following formula (I) (wherein R1 represents a hydrogen atom or a C1-C3 alkyl group; and R2 represents an aliphatic hydrocarbon group or an alicyclic hydrocarbon group), wherein the repeating unit represented by formula (I) has a copolymerization ratio of 90 mass% or more in the block chain (B).

  本发明的目的是提供一种新型共聚物，可用作颜料等的分散剂。这种新型共聚物包含嵌段链 (A)，该嵌段链包含至少一个重复单元，该重复单元选自由具有叔氨基的重复单元和具有季铵盐基团的重复单元组成的组；以及 嵌段链 (B)，该嵌段链包含具有酸性基团的重复单元和由下式 (I) 代表的重复单元（其中 R1 代表氢原子或 C1-C3 烷基；其中 R1 代表氢原子或 C1-C3 烷基；R2 代表脂肪族烃基或脂环族烃基），其中式 (I) 所代表的重复单元在嵌段链 (B) 中的共聚比例为 90% 或以上。
• Ion triggerable, cationic polymers, a method of making same and items using same
  申请人：——

  公开号：US20040055704A1

  公开（公告）日：2004-03-25

  The present invention is directed to ion triggerable, water-dispersible cationic polymers. The present invention is also directed to a method of making ion triggerable, water-dispersible cationic polymers and their applicability as binder compositions. The present invention is further directed to fiber-containing fabrics and webs comprising ion triggerable, water-dispersible binder compositions and their applicability in water-dispersible personal care products, such as wet wipes.

  本发明涉及可离子触发的水分散性阳离子聚合物。本发明还涉及一种制造可离子触发的水分散阳离子聚合物的方法及其作为粘结剂组合物的适用性。本发明还涉及包含可离子触发的水分散性粘合剂组合物的含纤维织物和纤维网，以及它们在水分散性个人护理产品（如湿巾）中的适用性。
• Process for preparing an aqueous dispersion of a quaternary ammonium salt containing vinyl copolymer
  申请人：Calhoun C. Glenn

  公开号：US20050209396A1

  公开（公告）日：2005-09-22

  A method of making an ion triggerable cationic polymer by solution copolymerizing one or more vinyl-functional cationic monomers, one or more water insoluble or hydrophobic vinyl monomers with alkyl side chains up to 4 carbons long, and, optionally, a minor amount of one or more vinyl monomers with linear or branched alkyl groups longer than 4 carbons, alkyl hydroxy, polyoxyalkylene, or other functional groups. The solution polymerization is accomplished by free radical polymerization in a mixture of acetone and water.

  一种通过溶液共聚一种或多种乙烯基官能团阳离子单体、一种或多种具有长度不超过 4 个碳原子的烷基侧链的水不溶性或疏水性乙烯基单体以及少量具有长度超过 4 个碳原子的直链或支链烷基、烷基羟基、聚氧亚烷基或其他官能团的乙烯基单体来制造可离子触发的阳离子聚合物的方法。溶液聚合是在丙酮和水的混合物中通过自由基聚合完成的。
• Polymers suitable for paper making additives and process of manufacturing them
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0919578B1

  公开（公告）日：2004-02-11