7-(diethoxyphosphoryloxy)coumarin-4-acetic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(diethoxyphosphoryloxy)coumarin-4-acetic acid
• 英文别名: 2-(7-Diethoxyphosphoryloxy-2-oxochromen-4-yl)acetic acid；2-(7-diethoxyphosphoryloxy-2-oxochromen-4-yl)acetic acid
• 化学式: C₁₅H₁₇O₈P
• 分子量: 356.269
• InChiKey: CYMJCPHPSHIDPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,3-丙酮二羧酸 在 lithium hydroxide 、 氯化亚砜 、 硫酸 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 21.0h， 生成 7-(diethoxyphosphoryloxy)coumarin-4-acetic acid
  参考文献：
  名称：

  Enzymatic Profiling System in a Small-Molecule Microarray

  摘要：

  We have developed a microarray-based strategy for detection of three major classes of hydrolytic enzymes on the basis of their catalytic activities. This enables the sensitive detection of proteins not merely by their bindings but rather by their enzymatic activities. This may provide a valuable tool for screening, identification, and characterization of new enzymes in a high-throughput fashion.

  DOI：

  10.1021/ol034233h

文献信息

• Enzymatic Profiling System in a Small-Molecule Microarray
  作者：Qing Zhu、Mahesh Uttamchandani、Dongbo Li、Marie L. Lesaicherre、Shao Q. Yao

  DOI：10.1021/ol034233h

  日期：2003.4.1

  We have developed a microarray-based strategy for detection of three major classes of hydrolytic enzymes on the basis of their catalytic activities. This enables the sensitive detection of proteins not merely by their bindings but rather by their enzymatic activities. This may provide a valuable tool for screening, identification, and characterization of new enzymes in a high-throughput fashion.