potassium 6-(2-phenylacetylamino)penicillanate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: potassium 6-(2-phenylacetylamino)penicillanate
• 英文别名: potassium 6-(2-phenylacetamido)penicillanate；potassium 6-phenylacetamidopenicillanate；potassium;(2S,5R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• 化学式: C₁₆H₁₇N₂O₄S*K
• 分子量: 372.486
• InChiKey: IYNDLOXRXUOGIU-QMPLWUNKSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.47
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  potassium 6-(2-phenylacetylamino)penicillanate 生成 6-aminopenicillanic acid
  参考文献：
  名称：

  SZEWCZUK, A.;ZIOMEK, E.;MORDARSKI, M.;SIEWINSKI, M.;SOBIECH, K.;WIECZOREK+

  摘要：

  DOI：

文献信息

• Bis-esters of methanediol with penicillins and penicillanic acid
  申请人：Pfizer Inc.

  公开号：US04244951A1

  公开（公告）日：1981-01-13

  6'-Acylaminopenicillanoyloxymethyl esters of penicillanic acid 1,1-dioxide are useful as antibacterial agents. The 6'-aminopenicillanoyloxymethyl ester, halomethyl esters, alkylsulfonyloxymethyl esters and arylsulfonyloxymethyl esters of penicillanic acid 1,1-dioxide are all useful intermediates for the aforesaid antibacterial agents.

  6'-酰胺基青霉烷酸氧甲基酯是一种有用的抗菌剂。6'-氨基青霉烷酸氧甲基酯、卤代甲基酯、烷基磺酰氧甲基酯和芳基磺酰氧甲基酯是上述抗菌剂的有用中间体。
• Process for the production of penicillanic acid compounds
  申请人：Yoshitomi Pharmaceutical Industries, Ltd.

  公开号：US04942229A1

  公开（公告）日：1990-07-17

  An improved process for the production of penicillic acid compounds, especially chloromethyl ester of penicillin G, penicillin V or sulbactam is disclosed.

  本发明揭示了一种改进的生产青霉酸类化合物的方法，特别是氯甲基青霉素G，青霉素V或舒巴坦的方法。
• Penicillin esters
  申请人：——

  公开号：US04046759A1

  公开（公告）日：1977-09-06

  There disclose new penicillin esters and S-oxides thereof which are of value as intermediates for the preparation of various cephalosporin antibiotics.

  有新的青霉素酯和其S-氧化物被披露，这些化合物作为制备各种头孢菌素抗生素的中间体具有价值。
• Bis-esters of alkanediols as antibacterial agents
  申请人：Pfizer Inc.

  公开号：US04364957A1

  公开（公告）日：1982-12-21

  6-Acylaminopenicillanoyloxymethyl esters and 1-(6-acylaminopenicillanoyloxy)ethyl esters of 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide are useful as antibacterial agents. The 6-aminopenicillanoyloxymethyl ester, the 1-(6-aminopenicillanoyloxy)ethyl ester and certain other mono-substituted methyl and ethyl esters of 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide are useful intermediates to the aforesaid antibacterial agents.

  6-酰基氨基青霉烷酰氧甲基酯和1-(6-酰基氨基青霉烷酰氧基)乙基酯的2-β-乙酰氧甲基-2-α-甲基-(5R)青霉烷-3-α-羧酸1,1-二氧化物作为抗菌剂有用。6-氨基青霉烷酰氧甲基酯，1-(6-氨基青霉烷酰氧基)乙基酯和2-β-乙酰氧甲基-2-α-甲基-(5R)青霉烷-3-α-羧酸1,1-二氧化物的某些其他单取代甲基和乙基酯是前述抗菌剂的有用中间体。
• Bis-esters of alkanediols, pharmaceutical compositions thereof and intermediates therefor
  申请人：PFIZER INC.

  公开号：EP0059046A1

  公开（公告）日：1982-09-01

  6-Acylaminopenicillancyloxymethyl esters and 1-(6-acyl- aminopenicillanoyloxy)ethyl esters of 2-beta-acetoxymethyl-2- alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide are useful as antibacterial agents. The 6-aminopenicillanoyloxymethyl ester, the 1-(6-aminopenicillanoyloxy)ethyl ester and certain other mono-substituted methyl and ethyl esters of 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha- carboxylic acid 1,1-dioxide are useful intermediates to the aforesaid antibacterial agents.

  2-beta-acetoxymethyl-2-α-methyl-(5R)penam-3-α-carboxylic acid 1,1-dioxide 的 6-酰氨基青霉烷氧基甲酯和 1-(6-酰氨基青霉烷氧基)乙酯可用作抗菌剂。 2-beta-acetoxymethyl-2-α-methyl-(5R)penam-3-α-carboxylic acid 1,1-dioxide 的 6-氨基青霉烷氧基甲酯、1-(6-氨基青霉烷氧基)乙酯和某些其他单取代甲基和乙酯是上述抗菌剂的有用中间体。