2-(4-trifluoromethyl-benzyloxy)-ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-trifluoromethyl-benzyloxy)-ethanol
• 英文别名: 2-[[4-(trifluoromethyl)phenyl]methoxy]ethanol
• 化学式: C₁₀H₁₁F₃O₂
• 分子量: 220.191
• InChiKey: YPUMSOBDUFUIAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Phenylmethoxycarbonylamino 4-chlorobenzenesulfonate 、 2-(4-trifluoromethyl-benzyloxy)-ethanol 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成 C₂₄H₂₁ClF₃NO₆S
  参考文献：
  名称：

  N-杂环卡宾有机催化酰胺的远程C(sp3)-H酰化和级联环化

  摘要：

  开发了一种 N-杂环卡宾催化的酰胺的远程 C(sp 3 )-H 酰化，并结合了级联环化。在温和条件下以高达 99% 的产率合成了 120 多种具有不同取代基的功能化 δ-氨基酮和异喹啉酮。初步的机理研究揭示了有机催化自由基反应的机理。

  DOI：

  10.1002/anie.202116629
• 作为产物：
  描述：

  1-(2-Benzyloxy-ethoxymethyl)-4-trifluoromethyl-benzene 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以88%的产率得到2-(4-trifluoromethyl-benzyloxy)-ethanol
  参考文献：
  名称：

  Rational Design of Benzyl-Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis

  摘要：

  DOI：

  10.1021/jo980823v

文献信息

• [EN] SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'INDAZOLE SUBSTITUÉS ACTIFS EN TANT QU'INHIBITEURS DE KINASES
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2012152763A1

  公开（公告）日：2012-11-15

  The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

  本发明涉及替代吲唑化合物，其调节蛋白激酶的活性，因此在治疗由失调的蛋白激酶活性引起的疾病，如癌症方面具有用处。本发明还提供了制备这些化合物的方法，包括这些化合物的药物组合物，以及利用这些化合物或含有它们的药物组合物治疗疾病的方法。
• SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
  申请人：Lombardi Borgia Andrea

  公开号：US20140080807A1

  公开（公告）日：2014-03-20

  The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

  本发明涉及取代吲唑化合物，其调节蛋白激酶活性，因此在治疗由失调的蛋白激酶活性引起的疾病，如癌症方面非常有用。本发明还提供制备这些化合物的方法，包括这些化合物的药物组合物，以及利用这些化合物或含有它们的药物组合物治疗疾病的方法。
• Substituted indazole derivatives active as kinase inhibitors
  申请人：Lombardi Borgia Andrea

  公开号：US09408850B2

  公开（公告）日：2016-08-09

  The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

  本发明涉及替代吲唑化合物，其调节蛋白激酶的活性，因此在治疗由失调蛋白激酶活性引起的疾病（如癌症）方面非常有用。本发明还提供制备这些化合物的方法，包括这些化合物的制药组合物，以及利用这些化合物或含有它们的制药组合物治疗疾病的方法。
• Substituted indazole derivatives active as kinase inhibitiors
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：US10028934B2

  公开（公告）日：2018-07-24

  The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

  本发明涉及取代的吲唑化合物，这些化合物可调节蛋白激酶的活性，因此可用于治疗由蛋白激酶活性降低引起的疾病，如癌症。本发明还提供了制备这些化合物的方法、含有这些化合物的药物组合物，以及利用这些化合物或含有这些化合物的药物组合物治疗疾病的方法。
• SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：US20160310465A1

  公开（公告）日：2016-10-27

  The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.