2,4-dichlorophenyl-4-methylphenoxyacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dichlorophenyl-4-methylphenoxyacetate
• 英文别名: (2,4-Dichlorophenyl) 2-(4-methylphenoxy)acetate
• 化学式: C₁₅H₁₂Cl₂O₃
• 分子量: 311.164
• InChiKey: IPLLGTHPBGFKCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-dichlorophenyl-4-methylphenoxyacetate 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 氯仿 为溶剂， 反应 6.0h， 以81%的产率得到2,4-dichlorophenyl-4-bromomethyl-phenoxyacetate
  参考文献：
  名称：

  A Convenient, Large-Scale Preparation of 2,4-Dichlorophenyl-4-bromomethyl-phenoxyacetate Suitable for Resin Anchorage of the First Fmoc Amino Acid

  摘要：

  2,4-dichlorophenyl-4-bromomethyl-phenoxyacetate 3 was prepared by NBS treatement of 2,4-dichlorophenyl-4-methylphenoxyacetate 2. This ester is a key intermediate in the preparation of 2,4-dichlorophenyl-N(alpha)-Fmoc-aminoacyl-4-oxymethylphenoxy-acetates suitable for anchorage of the first amino acid on amine-functionalized polymers.

  DOI：

  10.1080/00397919408011495
• 作为产物：
  描述：

  (4-甲基苯氧基)乙酸 、 2,4-二氯酚 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以88%的产率得到2,4-dichlorophenyl-4-methylphenoxyacetate
  参考文献：
  名称：

  A Convenient, Large-Scale Preparation of 2,4-Dichlorophenyl-4-bromomethyl-phenoxyacetate Suitable for Resin Anchorage of the First Fmoc Amino Acid

  摘要：

  2,4-dichlorophenyl-4-bromomethyl-phenoxyacetate 3 was prepared by NBS treatement of 2,4-dichlorophenyl-4-methylphenoxyacetate 2. This ester is a key intermediate in the preparation of 2,4-dichlorophenyl-N(alpha)-Fmoc-aminoacyl-4-oxymethylphenoxy-acetates suitable for anchorage of the first amino acid on amine-functionalized polymers.

  DOI：

  10.1080/00397919408011495

文献信息

• A Convenient, Large-Scale Preparation of 2,4-Dichlorophenyl-4-bromomethyl-phenoxyacetate Suitable for Resin Anchorage of the First Fmoc Amino Acid
  作者：Loic René、Bernard Badet

  DOI：10.1080/00397919408011495

  日期：1994.2

  2,4-dichlorophenyl-4-bromomethyl-phenoxyacetate 3 was prepared by NBS treatement of 2,4-dichlorophenyl-4-methylphenoxyacetate 2. This ester is a key intermediate in the preparation of 2,4-dichlorophenyl-N(alpha)-Fmoc-aminoacyl-4-oxymethylphenoxy-acetates suitable for anchorage of the first amino acid on amine-functionalized polymers.