S-(2-tetrahydropyranyl)-4-bromothiophenol

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: S-(2-tetrahydropyranyl)-4-bromothiophenol
• 英文别名: (4-Bromophenyl-Thio]-Tetrahydro-2H-Pyran；2-(4-bromophenyl)sulfanyloxane
• 化学式: C₁₁H₁₃BrOS
• 分子量: 273.194
• InChiKey: PZIGSLFZOYYUKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  S-(2-tetrahydropyranyl)-4-bromothiophenol 在 碘 、 silver nitrate 、 magnesium 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.17h， 生成 (disulfanediylbis(4,1-phenylene))bis((4-((methoxymethoxy)methyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol)
  参考文献：
  名称：

  Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors

  摘要：

  DOI：

  10.1016/j.bmc.2020.115871
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 4-溴苯硫酚 在 poly(4-vinylpyridine) supported copper(II) oxide nanoparticles 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 S-(2-tetrahydropyranyl)-4-bromothiophenol
  参考文献：
  名称：

  P4VPy–CuO nanoparticles as a novel and reusable catalyst: application at the protection of alcohols, phenols and amines

  摘要：

  采用了超声波辐照法合成了P4VPy–CuO纳米粒子。通过X射线衍射、扫描电子显微镜、透射电子显微镜和傅里叶变换红外光谱对合成的纳米粒子的相关性质进行了研究。在鉴定之后，制备的试剂被用于促进不同类型的醇、酚和胺的保护反应。操作简便、反应时间短、产率高、成本相对较低以及催化剂的重复使用性是所报道方法的显著特点。

  DOI：

  10.1007/s13738-016-0887-x

文献信息

• P4VPy–CuO nanoparticles as a novel and reusable catalyst: application at the protection of alcohols, phenols and amines
  作者：Farhad Shirini、Abdollah Fallah-Shojaei、Masoumeh Abedini、Laleh Samavi

  DOI：10.1007/s13738-016-0887-x

  日期：2016.9

  P4VPy–CuO nanoparticles were synthesized using ultrasound irradiations. Relevant properties of the synthesized nanoparticles were investigated by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. After identification, the prepared reagent was used for the promotion of different types of protection reactions of alcohols, phenols and amines. Easy workup, short reaction times, excellent yields, relatively low cost and reusability of the catalyst are the striking features of the reported methods.

  采用了超声波辐照法合成了P4VPy–CuO纳米粒子。通过X射线衍射、扫描电子显微镜、透射电子显微镜和傅里叶变换红外光谱对合成的纳米粒子的相关性质进行了研究。在鉴定之后，制备的试剂被用于促进不同类型的醇、酚和胺的保护反应。操作简便、反应时间短、产率高、成本相对较低以及催化剂的重复使用性是所报道方法的显著特点。
• MATERIALS FOR ELECTRONIC DEVICES
  申请人：MERCK PATENT GMBH

  公开号：US20150340627A1

  公开（公告）日：2015-11-26

  The present application relates to a compound of a formula (I), (II) or (III). The compound can be used in an electronic device, preferably an organic electronic device.

  本申请涉及公式(I)、(II)或(III)的化合物。该化合物可用于电子设备中，最好是有机电子设备。
• 19-nor-steroids
  申请人：ROUSSEL UCLAF

  公开号：US05707982A1

  公开（公告）日：1998-01-13

  A 19-nor-steroid having a formula selected from the group consisting of ##STR1## wherein the A and B rings have a structure selected from the group consisting of ##STR2##

  一种19-去甲基类固醇，其公式选择自以下组合：##STR1## 其中A和B环具有以下结构之一：##STR2##
• 19-Nor-steroids
  申请人：Aventis Pharma S.A.

  公开号：US06790971B1

  公开（公告）日：2004-09-14

  A 19-nor-steroid having a formula selected from the group consisting of wherein the A and B rings have a structure selected from the group consisting of having hormonal properties and their preparation and novel intermediates.

  一种19-去甲基类固醇，其化学式从以下组中选择，其中A环和B环具有激素特性的结构，以及它们的制备和新型中间体。
• Synthesis of triarylphosphines having para –SH and –SMe groups
  作者：Fabio Ragaini、Luca Lunardi、Diego Tomasoni、Vittoria Guglielmi

  DOI：10.1016/j.jorganchem.2004.08.031

  日期：2004.11

  The phosphines P(C6H4-4-SR)(3) (R = H, Me, 2-C5H9O) and (C6H4-4-SR)(2)PCH2CH2P(C6H4-4-SR)(2) (R = H, Me) have been synthesized. The phosphines with -SMe groups can be prepared by reaction of 4-BrC6H4SMe with either BuLi or magnesium (to generate the corresponding Grignard compound) followed by reaction with PCl3 or Cl2PCH2CH2PCl2, respectively. The methyl group can be eliminated by reaction with sodium in liquid NH3. Other methods of protection/deprotection of the thiol group failed to afford the desired compounds. Reaction of 4-BrC6H4SH with dihydropyrane afforded the protected thiol 4-BrC6H4S-2-C5H9O from which the corresponding phosphine was successfully synthesized. However, attempts to remove the tetrahydropyranyl group by reaction with AgNO3-HCl, gave an insoluble polymer as product. Reaction of P(C6H4SR)(3) (R = H, Me) with Ni(CO)(4) affords the corresponding mono phosphine complex quantitatively. The complex with the unprotected thiol group can be absorbed on a gold surface and the corresponding v(CO) bands were detected by grazing angle Fourier transform infrared reflection absorption spectroscopy (grazing angle FTIR-RAS). Reaction of Rh(acac)(CO)(2) with P(C6H4SR)(3) (R = Me) affords the complex Rh(acac) (CO)(P(C6H4SR)(3)) (R = Me), but if R = H a polymer insoluble in any solvent was obtained. The same occurs in the case of PtCl2(CO)(DMSO). Apparently, once P(C6H4SH)(3) is coordinated to a metal not in the zero oxidation state, oxidation of the thiol group to disulphide becomes very easy even in a dinitrogen atmosphere. (C) 2004 Elsevier B.V. All rights reserved.