fluoromethyl benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: fluoromethyl benzoate
• 化学式: C₈H₇FO₂
• 分子量: 154.141
• InChiKey: VPLALCFPHOLSTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 苯甲酰氟 在 三(二甲氨基)锍二氟三甲基硅酸 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以98%的产率得到fluoromethyl benzoate
  参考文献：
  名称：

  O-氟甲基羧酸盐和O-氟甲基氨基甲酸酯

  摘要：

  酰基氟与单体甲醛之间的氟化物催化反应以可接受的收率提供了氟甲基羧酸盐。-可容易地从相应的二氯化合物获得的氟甲基氟甲酸酯与胺缩合以得到氟甲基氨基甲酸酯。

  DOI：

  10.1016/0040-4020(95)00251-3

文献信息

• Electrochemical Fluorination of (Arylthio)methyl Carboxylates and γ-Phenylthio-γ-butyrolactone Derivative
  作者：Satoshi Ito、Kaori Kondo、Hideki Ishii、Shinsuke Inagi、Toshio Fuchigami

  DOI：10.1149/1945-7111/ac07c2

  日期：2021.6.1

  Electrochemical fluorination of various (arylthio)methyl carboxylates was carried out in aprotic organic solvents containing poly(HF) salts to provide the corresponding O-fluoromethyl carboxylates in good to moderate yield. Electrochemical fluorination of a cyclic analogue, a γ-phenylthio-γ-butyrolactone derivative was also achieved under ultrasonication to give the corresponding 4-fluorinated product

  各种（芳硫基）甲基羧酸盐的电化学氟化在含有聚（HF）盐的非质子有机溶剂中进行，以良好到中等的产率提供相应的O-氟甲基羧酸盐。在超声处理下也实现了环状类似物γ-苯硫基-γ-丁内酯衍生物的电化学氟化，以中等产率得到相应的4-氟化产物。
• PHOTOACID GENERATOR, COPOLYMER, CHEMICALLY AMPLIFIED RESIST COMPOSITION, AND METHOD OF FORMING PATTERN USING THE CHEMICALLY AMPLIFIED RESIST COMPOSITION
  申请人：OH Jung Hoon

  公开号：US20100143843A1

  公开（公告）日：2010-06-10

  Disclosed are a photoacid generator, a copolymer, a chemically amplified resist composition, and a method of forming a pattern using the chemically amplified resist composition. The photoacid is connected with a main chain of the copolymer, whereby the photoacid is equally dispersed within a resist layer, and characteristics of line edge roughness of a resist pattern is improved.

  本发明涉及一种光酸发生剂、一种共聚物、一种化学放大型光刻胶组合物以及使用该化学放大型光刻胶组合物形成图案的方法。光酸发生剂与共聚物的主链相连接，从而使光酸发生剂在光刻胶层内均匀分散，并改善光刻胶图案线边粗糙度的特性。
• Fluorination of proteins and peptides for F-18 positron emission tomography
  申请人：Immunomedics, Inc.

  公开号：US20020119096A1

  公开（公告）日：2002-08-29

  Thiol-containing peptides can be radiolabeled with fluorine-18 (F-18) by reacting a peptide comprising a free thiol group with an F-18-bound labelling reagent which also has a group that is reactive with thiols. The resulting F-18-labeled peptides may be targeted to a tissue of interest using bispecific antibodies or bispecific antibody fragments having one arm specific for the F-18-labeled peptide or a low molecular weight hapten conjugated to the F-18-labeled peptide, and another arm specific to the targeted tissue. The targeted tissue is subsequently visualized by clinical positron emission tomography.

  含硫醇的肽可以用氟-18（F-18）进行放射性标记，方法是将含有游离硫醇基团的肽与同样具有与硫醇反应的基团的 F-18 结合型标记试剂反应。由此产生的 F-18 标记肽可使用双特异性抗体或双特异性抗体片段靶向感兴趣的组织，双特异性抗体或双特异性抗体片段的一个臂特异于 F-18 标记肽或与 F-18 标记肽结合的低分子量合体，另一个臂特异于靶组织。靶组织随后可通过临床正电子发射断层扫描显像。
• FLUORINATION OF PROTEINS AND PEPTIDES FOR F-18 POSITRON EMISSION TOMOGRAPHY
  申请人：Immunomedics, Inc.

  公开号：EP1009726A1

  公开（公告）日：2000-06-21
• Compositions and methods for imaging expression of cell surface receptors
  申请人：Shim Hyunsuk

  公开号：US20070258893A1

  公开（公告）日：2007-11-08

  The present disclosure provides imaging agents and methods for imaging surface cell receptors, particularly CXCR4 receptors and biological conditions associated with the expression of CXCR4 receptors, including, but not limited to, cancer and metastasis. In embodiments, the present disclosure provides radiolabeled CXCR4 peptide antagonists detectable in vivo or in vitro by a PET scanner.