2-(1-adamantyl)ethyl acrylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(1-adamantyl)ethyl acrylate
• 英文别名: 2-(1-Adamantyl)ethyl prop-2-enoate
• 化学式: C₁₅H₂₂O₂
• 分子量: 234.338
• InChiKey: VIEWIDALCNRAOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-adamantyl)ethyl acrylate 在 盐酸 、 三乙胺 、 tin(ll) chloride 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 5.67h， 生成 2-(1-adamantyl)ethyl 5-[hydroxy(tetrahydrofuran-2-yl)amino]isoxazole-3-carboxylate
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents

  摘要：

  A versatile synthesis of novel 5-hydroxylaminoisoxazoles bearing adamantane moieties has been accomplished using the heterocyclization reactions of readily available unsaturated esters by the treatment with tetranitromethane in the presence of triethylamine and subsequent reduction of resulting 5-nitroisoxazoles by SnCl2 with the participation of THF. A number of obtained isoxazole derivatives were evaluated for their antioxidative activity, inhibition of lipoxygenases and impact on the rat liver mitochondria. The majority of tested compounds demonstrated moderate antiradical activity in DPPH test (up to EC50 16 mu M). The same compounds strongly inhibited soybean lipoxygenase (up to IC50 0.4 mu M) and Fe2+- and Fe3+-induced lipid peroxidation (LP) of rat brain cortex homogenate (up to IC50 0.3 mu M). All tested isoxazole derivatives promoted the phosphorylating respiratory activity simultaneously with maximal stimulated respiratory activity of mitochondria and do not reveal any toxicity towards the primary culture of rat cortex neurons. (c) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.12.040
• 作为产物：
  描述：

  1-金刚烷乙醇 、 丙烯酰氯 以 二氯甲烷 为溶剂， 以78%的产率得到2-(1-adamantyl)ethyl acrylate
  参考文献：
  名称：

  基于异恶唑核心与金刚烷连接的传播的黄病毒繁殖抑制剂。

  摘要：

  黄病毒引起的感染对全世界的公共卫生构成了巨大的威胁。寻找靶向tick传播的黄病毒的治疗相关化合物需要探索新的化学型。在本工作中，通过我们独特的通用合成方法，获得了一系列具有多种空间和电子效应的带有取代基的新型多官能化异恶唑衍生物，并在体外研究了它们对壁虱传播性脑炎，鄂木斯克出血热和Powassan病毒的抗病毒活性。大多数研究的异恶唑显示出低微摩尔范围的活性。对于测试的化合物未观察到明显的细胞毒性。含金刚烷基部分的先导化合物5-氨基异恶唑衍生物具有很强的抗病毒活性和极好的治疗指数。

  DOI：

  10.1016/j.bioorg.2019.03.028

文献信息

• Ink composition, inkjet recording method, and printed material
  申请人：FUJIFILM Corporation

  公开号：EP1903080A1

  公开（公告）日：2008-03-26

  An ink composition is provided that includes (A) an N-vinyllactam, (B) a polymerization initiator, (C) a basic compound, (D) a colorant, and (E) a dispersant, the content of the N-vinyllactam (A) being at least 15 wt % of the total weight of the ink composition, and the dispersant (E) being an acidic dispersant. There is also provided an inkjet recording method that includes (a1) a step of discharging the ink composition onto a recording medium, and (b1) a step of curing the ink composition by irradiating the discharged ink composition with actinic radiation. Furthermore, there is provided a printed material recorded by the inkjet recording method.

  提供了一种墨水组合物，其中包括 (A)一种 N-乙烯内酰胺、(B)一种聚合引发剂、(C)一种碱性化合物、(D)一种着色剂和(E)一种分散剂，N-乙烯内酰胺 (A) 的含量至少占墨水组合物总重量的 15 wt%，分散剂 (E) 是一种酸性分散剂。还提供了一种喷墨记录方法，该方法包括 (a1) 将墨水组合物排放到记录介质上的步骤，以及 (b1) 通过用阳极辐射照射排放的墨水组合物来固化墨水组合物的步骤。此外，还提供了用喷墨记录方法记录的印刷材料。
• Ink composition, inkjet recording method, printed material, and ink set
  申请人：FUJIFILM Corporation

  公开号：EP1964893A1

  公开（公告）日：2008-09-03

  An ink composition is provided that includes (A) a pigment, (B) a polymerizable monomer, (C) a polymerization initiator, and (D) a dispersant, the content of the pigment being no greater than 1 wt % of the entire ink composition, and the ratio (D/A) of the weight A of the pigment to the weight D of the dispersant in the ink composition satisfying the relationship 0.5 < D/A ≤ 15. There is also provided an inkjet recording method that includes (a1) a step of discharging the ink composition onto a recording medium, and (b1) a step of curing the ink composition by irradiating the discharged ink composition with actinic radiation. There is also provided a printed material recorded by the inkjet recording method. There is also provided an ink set comprising the ink composition.

  提供了一种墨水组合物，其中包括(A)颜料、(B)可聚合单体、(C)聚合引发剂和(D)分散剂，颜料的含量不大于整个墨水组合物的 1 wt %，且墨水组合物中颜料重量 A 与分散剂重量 D 之比 (D/A) 满足 0.5 < D/A ≤ 15 的关系。还提供了一种喷墨记录方法，该方法包括 (a1) 将墨水组合物排放到记录介质上的步骤，以及 (b1) 通过用阳极辐射照射排放的墨水组合物来固化墨水组合物的步骤。还提供了一种用喷墨记录方法记录的印刷材料。还提供了包含该墨水组合物的墨水套装。
• Ink set for inkjet recording and inkjet recording method
  申请人：FUJIFILM Corporation

  公开号：EP1975210A1

  公开（公告）日：2008-10-01

  An ink set for inkjet recording is provided that includes at least a colored liquid comprising at least a radically polymerizable compound, a photopolymerization initiator, and a colorant and an undercoat liquid comprising at least a radically polymerizable compound and a photopolymerization initiator, the undercoat liquid comprising a sensitizer represented by Formula (I) below. In Formula (I) above, X denotes O, S, or NR, n denotes 0 or 1, R denotes a hydrogen atom, an alkyl group, or an acyl group, and R1, R2, R3, R4, R5, R6, R7, and R8 independently denote a hydrogen atom or a monovalent substituent. There is also provided an inkjet recording method employing the ink set for inkjet recording, the method including a step of applying the undercoat liquid on top of a recording medium, a step of semi-curing the undercoat liquid, and a step of carrying out image formation by discharging the colored liquid on top of the semi-cured undercoat liquid.

  提供了一种用于喷墨记录的墨水组，它至少包括一种由至少一种可径向聚合的化合物、一种光聚合引发剂和一种着色剂组成的有色液体，以及一种由至少一种可径向聚合的化合物和一种光聚合引发剂组成的底层液体，底层液体包括由下式（I）代表的敏化剂。 在上式（I）中，X 表示 O、S 或 NR，n 表示 0 或 1，R 表示氢原子、烷基或酰基，R1、R2、R3、R4、R5、R6、R7 和 R8 独立地表示氢原子或单价取代基。还提供了一种喷墨记录方法，该方法采用了用于喷墨记录的墨水组，该方法包括在记录介质上涂敷底层液体的步骤、半固化底层液体的步骤，以及通过在半固化底层液体上排放有色液体来形成图像的步骤。
• Ink composition
  申请人：FUJIFILM Corporation

  公开号：EP2042573A1

  公开（公告）日：2009-04-01

  An ink composition is provided that includes compound A represented by Formula (I) below, compound B represented by Formula (II) below, and a polymerizable compound, wherein, in Formula (I), X denotes O, S, or NRa, n1 denotes 0 or 1, Ra, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 independently denote a hydrogen atom or a monovalent substituent, and two of R1, R2, R3, R4, R5, R6, R7, and R8 that are adjacent may be linked to each other to form a ring, and in Formula (II), X denotes O, S, or NRb, n2 denotes 0 or 1, Rb, R11, R12, R13, R14, R15, R16, R17, and R18 independently denote a hydrogen atom or a monovalent substituent, and two of R11, R12, R13, and R14 that are adjacent may be linked to each other to form a ring. There is also provided an inkjet recording method comprising (a) a step of discharging the ink composition onto a recording medium, and (b) a step of curing the ink composition by irradiating the discharged ink composition with actinic radiation.

  提供了一种油墨组合物，其中包括下式 (I) 所代表的化合物 A、下式 (II) 所代表的化合物 B 和一种可聚合化合物、 其中，在式 (I) 中，X 表示 O、S 或 NRa，n1 表示 0 或 1，Ra、R1、R2、R3、R4、R5、R6、R7、R8、R9 和 R10 独立地表示氢原子或一价取代基，相邻的两个 R1、R2、R3、R4、R5、R6、R7 和 R8 可相互连接形成一个环、在式 (II) 中，X 表示 O、S 或 NRb，n2 表示 0 或 1，Rb、R11、R12、R13、R14、R15、R16、R17 和 R18 独立地表示氢原子或单价取代基，相邻的两个 R11、R12、R13 和 R14 可彼此连接形成环。还提供了一种喷墨记录方法，包括(a)将墨水组合物排放到记录介质上的步骤，和(b)通过用阳极辐射照射排放的墨水组合物来固化墨水组合物的步骤。
• Ink composition, inkjet recording method, printed material, and molded printed material
  申请人：FUJIFILM Corporation

  公开号：EP2088176A1

  公开（公告）日：2009-08-12

  An ink composition is provided that includes (A) a compound having an ethylenically unsaturated double bond and a silicone chain, (B) a polymerizable monomer, and (C) a radical polymerization initiator, at least 75 wt % of the polymerizable monomer being a monofunctional polymerizable monomer selected from the group consisting of a monofunctional acrylate, a monofunctional methacrylate, a monofunctional vinyloxy compound, a monofunctional N-vinyl compound, a monofunctional ethylenically unsaturated carboxylic acid compound, a monofunctional acrylamide, and a monofunctional methacrylamide. There are also provided an inkjet recording method that includes (i-1) a step of discharging the ink composition onto a recording medium and (i-2) a step of curing the ink composition by irradiating the discharged ink composition with actinic radiation, a printed material formed by employing the inkjet recording method, and a molded printed material formed by subjecting the printed material to molding.

  提供了一种油墨组合物，它包括(A)具有乙烯基不饱和双键和硅酮链的化合物，(B)可聚合单体，和(C)自由基聚合引发剂，其中至少 75 wt % 的可聚合单体是选自以下组别的单官能团可聚合单体单官能度甲基丙烯酸酯、单官能度乙烯氧基化合物、单官能度 N-乙烯基化合物、单官能度乙烯基不饱和羧酸化合物、单官能度丙烯酰胺和单官能度甲基丙烯酰胺。还提供了一种喷墨记录方法，该方法包括（i-1）将墨水组合物排放到记录介质上的步骤和（i-2）通过用阳极辐射照射排放的墨水组合物来固化墨水组合物的步骤、通过使用喷墨记录方法形成的印刷材料和通过使印刷材料成型而形成的成型印刷材料。