2-<(N,N-diphenylamino)carbonyl>-5-<(4-methoxyphenyl)methyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-<(N,N-diphenylamino)carbonyl>-5-<(4-methoxyphenyl)methyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• 英文别名: 2-(N,N-Diphenylcarbamoyl)-5-(p-methoxyphenyl)methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid；2-Diphenylcarbamoyl-5-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid；2-(diphenylcarbamoyl)-5-[(4-methoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
• 化学式: C₃₁H₂₈N₂O₄
• 分子量: 492.574
• InChiKey: GMIRUEZGTURLHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二苯氨基甲酰氯 在 sodium hydroxide 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 4.08h， 生成 2-<(N,N-diphenylamino)carbonyl>-5-<(4-methoxyphenyl)methyl>-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  参考文献：
  名称：

  A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site

  摘要：

  The availability of peptide and non-peptide Ang II receptor antagonists has permitted the study of Ang II receptor heterogeneity. It is now widely recognized that there are at least two distinct Ang II receptor subtypes. AT(1) receptors are selective in their recognition of agents such as losartan, DuP 532, L-158,809, SK&F108566, and similar non-peptides. To date, all of the well-known actions of Ang II in mammals are blocked by the AT(1) selective antagonists such as losartan and are thus designated as being mediated by the AT(1) receptor. Although there have been reports of functional activity mediated through AT(2) sites, the pharmacological role for the AT(2) receptor has not yet been elucidated. Herein, we report the chemistry and SAR on a novel series of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids which have selective affinity for AT(2) receptors. The most potent of which (19) has an IC50 Of 30 nM for the AT(2) receptor in the rat adrenal radioligand binding assay.

  DOI：

  10.1021/jm00077a001

文献信息

• METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEMANGIOMA
  申请人：Gillies Mcindoe Research Institute

  公开号：EP4096648A1

  公开（公告）日：2022-12-07
• US5236934A
  申请人：——

  公开号：US5236934A

  公开（公告）日：1993-08-17
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEMANGIOMA<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE L'HÉMANGIOME
  申请人：DAVIS PAUL FRANK

  公开号：WO2021154102A1

  公开（公告）日：2021-08-05

  The present invention relates to methods and compositions for the treatment of hemangioma, and particularly, but not exclusively, methods and compositions for the treatment of infantile hemangioma. In certain aspects, the methods comprise locally administering an ACE inhibitor or an ATIIR2 antagonist to a subject. In other aspects, the methods comprise systemically administering two or more of an ACE inhibitor, a beta-blocker and an ATIIR2 antagonist. The present invention also relates to compositions that are suitable for local administration and comprise: an ACEi and a beta-blocker; an ACEi and an ATIIR2 antagonist; a beta-blocker and an AT11R2 antagonist; or, an ACEi, a beta-blocker, and an AT11R2 antagonist.
• A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site
  作者：Mary K. VanAtten、Carol L. Ensinger、Andrew T. Chiu、Dale E. McCall、Tam T. Nguyen、Ruth R. Wexler、Pieter B. M. W. M. Timmermans

  DOI：10.1021/jm00077a001

  日期：1993.12

  The availability of peptide and non-peptide Ang II receptor antagonists has permitted the study of Ang II receptor heterogeneity. It is now widely recognized that there are at least two distinct Ang II receptor subtypes. AT(1) receptors are selective in their recognition of agents such as losartan, DuP 532, L-158,809, SK&F108566, and similar non-peptides. To date, all of the well-known actions of Ang II in mammals are blocked by the AT(1) selective antagonists such as losartan and are thus designated as being mediated by the AT(1) receptor. Although there have been reports of functional activity mediated through AT(2) sites, the pharmacological role for the AT(2) receptor has not yet been elucidated. Herein, we report the chemistry and SAR on a novel series of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids which have selective affinity for AT(2) receptors. The most potent of which (19) has an IC50 Of 30 nM for the AT(2) receptor in the rat adrenal radioligand binding assay.