(3E)-N-(1,5-diphenylpent-3-enyl)-4-methoxybenzenamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3E)-N-(1,5-diphenylpent-3-enyl)-4-methoxybenzenamine
• 英文别名: (E)-N-(1,5-diphenylpent-3-en-1-yl)-4-methoxyaniline；N-[(E)-1,5-diphenylpent-3-enyl]-4-methoxyaniline
• 化学式: C₂₄H₂₅NO
• 分子量: 343.469
• InChiKey: IHCAHHAJZSUZRG-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲氧苯胺 在 bis(acetylacetonate)nickel(II) 3-己炔 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 (3E)-N-(1,5-diphenylpent-3-enyl)-4-methoxybenzenamine
  参考文献：
  名称：

  Alkyne as a Spectator Ligand for the Nickel-Catalyzed Multicomponent Connection Reaction of Diphenylzinc, 1,3-Butadiene, Aldehydes, and Amines

  摘要：

  Under nickel catalysis, in the presence of 3-hexyne, the aldimines of aromatic amines react with Ph2Zn and one molecule of butadiene to provide 1 exclusively, while the aldimines of aliphatic amines react with Ph2Zn and two molecules of butadiene to provide 2 exclusively, where 3-hexyne serves as a spectator ligand controlling the selective formation of 1 and 2.

  DOI：

  10.1021/ol0703480

文献信息

• Ni-Catalyzed Coupling of Butadiene, Aldimines, and Arylboronic Acids to Homoallylic Amines under Base-Free Conditions
  作者：Yu-Qing Li、Shi-Liang Shi

  DOI：10.1021/acs.organomet.1c00096

  日期：2021.7.26

  three-component coupling of butadiene, aldimines, and arylboronic acids to form synthetically important homoallylic amines. The starting materials are stable and readily available; especially, butadiene is an abundant chemical feedstock. This protocol provides rapid access to various (E)-homoallylic amines with excellent regio- and stereoselectivity by constructing two C–C bonds simultaneously. The mild

  在此，我们报告了镍催化的丁二烯、醛亚胺和芳基硼酸的三组分偶联，以形成合成重要的高烯丙基胺。原料稳定且容易获得；尤其是丁二烯是一种丰富的化学原料。该协议通过同时构建两个 C-C 键，提供了对具有出色区域和立体选择性的各种 ( E )-高烯丙基胺的快速访问。温和且无碱的反应条件为醛亚胺和芳基硼酸偶联部分提供了广泛的底物范围和高官能团耐受性。
• Alkyne as a Spectator Ligand for the Nickel-Catalyzed Multicomponent Connection Reaction of Diphenylzinc, 1,3-Butadiene, Aldehydes, and Amines
  作者：Masanari Kimura、Yasushi Tatsuyama、Keisuke Kojima、Yoshinao Tamaru

  DOI：10.1021/ol0703480

  日期：2007.5.1

  Under nickel catalysis, in the presence of 3-hexyne, the aldimines of aromatic amines react with Ph2Zn and one molecule of butadiene to provide 1 exclusively, while the aldimines of aliphatic amines react with Ph2Zn and two molecules of butadiene to provide 2 exclusively, where 3-hexyne serves as a spectator ligand controlling the selective formation of 1 and 2.