3-cyano-N-(2-(trifluoromethyl)phenyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-cyano-N-(2-(trifluoromethyl)phenyl)benzamide
• 英文别名: 3-cyano-N-[2-(trifluoromethyl)phenyl]benzamide
• 化学式: C₁₅H₉F₃N₂O
• 分子量: 290.244
• InChiKey: NTIQTEALZAJBSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  七氟-2-碘代丙烷 、 3-cyano-N-(2-(trifluoromethyl)phenyl)benzamide 在 ferrous(II) sulfate heptahydrate 、 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以59%的产率得到3-cyano-N-(2-(trifluoromethyl)-4-(heptafluoroisopropyl)phenyl)benzamide
  参考文献：
  名称：

  EP2835366

  摘要：

  公开号：

文献信息

• METHOD FOR PRODUCING ALKYLATED AROMATIC AMIDE DERIVATIVE
  申请人：Mitsui Chemicals Agro, Inc.

  公开号：US20150065721A1

  公开（公告）日：2015-03-05

  Provided is a method for producing an aromatic amide derivative represented by Formula (4), the method including a process in which an aromatic amide derivative represented by Formula (1) and a haloalkyl compound represented by Formula (3) are reacted with each other in the presence of a base and a metal or metal salt. In the formulae, each of X and Y represents a hydrogen atom, a halogen atom, or the like. A represents a hydrogen atom, an alkyl group, a group represented by Formula (2), or the like. Each of G 1 and G 2 represents an oxygen atom or the like. Q 1 represents a phenyl group or the like. R 1 represents a hydrogen atom, an alkyl group, or the like. Z 1 represents a haloalkyl group or the like. Xa represents an iodine atom or the like. m represents a number of from 1 to 4, n1 represents a number from 1 to 5, and n2 represents a number of from 1 to 4.

  提供的是一种制备由式（4）所表示的芳香酰胺衍生物的方法，该方法包括在碱和金属或金属盐的存在下，使由式（1）所表示的芳香酰胺衍生物和由式（3）所表示的卤代烷基化合物相互反应的过程。在式中，X和Y各自表示氢原子、卤素原子或类似物。A表示氢原子、烷基团、由式（2）表示的团或类似物。G1和G2各自表示氧原子或类似物。Q1表示苯基团或类似物。R1表示氢原子、烷基团或类似物。Z1表示卤代烷基团或类似物。Xa表示碘原子或类似物。m表示1到4的数字，n1表示1到5的数字，n2表示1到4的数字。
• Method for producing alkylated aromatic amide derivative
  申请人：Mitsui Chemicals Agro, Inc.

  公开号：US09353046B2

  公开（公告）日：2016-05-31

  Provided is a method for producing an aromatic amide derivative represented by Formula (4), the method including a process in which an aromatic amide derivative represented by Formula (1) and a haloalkyl compound represented by Formula (3) are reacted with each other in the presence of a base and a metal or metal salt. In the formulae, each of X and Y represents a hydrogen atom, a halogen atom, or the like. A represents a hydrogen atom, an alkyl group, a group represented by Formula (2), or the like. Each of G1 and G2 represents an oxygen atom or the like. Q1 represents a phenyl group or the like. R1 represents a hydrogen atom, an alkyl group, or the like. Z1 represents a haloalkyl group or the like. Xa represents an iodine atom or the like. m represents a number of from 1 to 4, n1 represents a number from 1 to 5, and n2 represents a number of from 1 to 4.

  提供了一种制备由公式（4）表示的芳香酰胺衍生物的方法，该方法包括在碱和金属或金属盐的存在下，通过将由公式（1）表示的芳香酰胺衍生物和由公式（3）表示的卤代烷基化合物互相反应的过程。在公式中，X和Y分别表示氢原子，卤素原子或类似物。A表示氢原子，烷基，由公式（2）表示的基团或类似物。G1和G2分别表示氧原子或类似物。Q1表示苯基或类似物。R1表示氢原子，烷基或类似物。Z1表示卤代烷基或类似物。Xa表示碘原子或类似物。m表示1到4的数字，n1表示1到5的数字，n2表示1到4的数字。
• US9353046B2
  申请人：——

  公开号：US9353046B2

  公开（公告）日：2016-05-31
• EP2835366
  申请人：——

  公开号：——

  公开（公告）日：——