5,5'-(2-methylpropane-1,1-diyl)bis(2-methylfuran)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 5,5'-(2-methylpropane-1,1-diyl)bis(2-methylfuran)
• 英文别名: 1-methyl-[bis-2,2-(5-methylfuran-2-yl)]propane；2-Methyl-5-[2-methyl-1-(5-methylfuran-2-yl)propyl]furan
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.296
• InChiKey: LXSFJIDBEUXTED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-甲基呋喃醛 在 甲醇 、 sodium tetrahydroborate 、 水 作用下， 以 环己烷 为溶剂， 反应 18.0h， 生成 5,5'-(2-methylpropane-1,1-diyl)bis(2-methylfuran)
  参考文献：
  名称：

  Catalyst-free synthesis of biodiesel precursors from biomass-based furfuryl alcohols in the presence of H₂O and air

  摘要：

  将基于生物质的呋喃醇二聚化为生物柴油前体，仅使用H₂O和空气，无需添加任何其他催化剂。

  DOI：

  10.1039/c9gc03179k

文献信息

• Practical Synthesis of Triaryl- and Triheteroarylmethanes by Reaction of Aldehydes and Activated Arenes Promoted by Gold(III) Chloride
  作者：Vijay Nair、K. G. Abhilash、N. Vidya

  DOI：10.1021/ol052423h

  日期：2005.12.1

  [reaction: see text] Electron-rich arenes condense efficiently with various aldehydes under the influence of AuCl3, thus opening up a practical route to triarylmethanes, which have important applications. The mild conditions employed are especially noteworthy.

  [反应：参见正文]在AuCl3的影响下，富电子芳烃与各种醛类有效地缩合，从而开辟了一条实用的生产三芳基甲烷的途径，这具有重要的应用前景。使用的温和条件尤其值得注意。
• Methods for producing cyclic and acyclic ketones
  申请人：The Regents of the University of California

  公开号：US10618856B2

  公开（公告）日：2020-04-14

  Provided herein are methods for producing cyclic and acyclic ketones from trimerization and dimerization of alkyl ketones, including for example methyl ketones. Such cyclic and acyclic ketones may be suitable for use as fuel and lubricant precursors, and may be hydrodeoxygenated to form their corresponding cycloalkanes and alkanes. Such cycloalkanes and alkanes may be suitable for use as fuels, including jet fuels, and lubricants.

  本文提供了通过烷基酮（例如包括甲基酮）的三聚和二聚反应生产环酮和无环酮的方法。此类环酮和无环酮可用作燃料和润滑剂前体，并可通过加氢脱氧生成相应的环烷烃和烷烃。此类环烷烃和烷烃可用作燃料（包括喷气燃料）和润滑剂。
• Bi(OTf)₃-Catalyzed One-Step Catalytic Synthesis of <i>N</i>-Boc or <i>N</i>-Cbz Protected α-Branched Amines
  作者：Jaray Jaratjaroonphong、Surisa Tuengpanya、Sureeporn Ruengsangtongkul

  DOI：10.1021/jo502540k

  日期：2015.1.2

  In this paper, N-Boc and N-Cbz protected alpha-branched amines are synthesized directly from commercially available aromatic/heteroaromatic compounds, aldehydes, and tert-butyl or benzyl carbamate bearing a variety of substituents. Bismuth(III) triflate is found to be a highly effective catalyst for this one-pot, three-component coupling reaction. In addition, the use of mild reaction conditions, low catalytic loading, easy removal of the N-protective group, and one-step synthesis under open-flask are advantages of the present procedure.
• Friedel−Crafts Arylation Reactions of <i>N</i>-Sulfonyl Aldimines or Sulfonamidesulfones with Electron-Rich Arenes Catalyzed by FeCl₃·6H₂O: Synthesis of Triarylmethanes and Bis-heteroarylarylmethanes
  作者：Ponnaboina Thirupathi、Sung Soo Kim

  DOI：10.1021/jo1010137

  日期：2010.8.6

  The FeCl3 center dot 6H(2)O-catalyzed Friedel-Crafts arylation reactions of N-sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes and heteroarenes, which lead to the formation of triarylmethanes and bis-heteroarylarylmethanes, are developed. The use of mild reaction conditions, low catalytic loading, high yield, and single step synthesis are the advantages of the present procedure.
• Convenient novel syntheses of 1,1-bis(heteroaryl)alkanes
  作者：Alan R. Katritzky、Linghong Xie、Wei Qiang Fan

  DOI：10.1021/jo00068a036

  日期：1993.7

  A variety of symmetrical 1,1-bis(heteroaryl)alkanes are prepared in excellent yields from the reaction of N-(alpha-benzotriazolylalkyl)carbamate 2 (itself easily available from the condensation of benzotriazole, an aldehyde, and an alkyl carbamate) with an excess of 2-methylthiophene or 2-methylfuran. When methyl N-(alpha-benzotriazolylalkyl)carbamate 2a is treated with 1 equiv of a heterocycle, the benzo-triazolylalkyl-substituted heterocycle is formed. These intermediates react further with other heterocycles to give unsymmetrical 1, 1-bis(heteroaryl)alkanes in good yields under mild conditions.