morpholine-4-carboxylic acid propyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: morpholine-4-carboxylic acid propyl ester
• 英文别名: Morpholin-4-carbonsaeure-propylester；Propyl morpholine-4-carboxylate
• 化学式: C₈H₁₅NO₃
• 分子量: 173.212
• InChiKey: CQNVFYRBKDLYQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 氯甲酸丙酯 生成 morpholine-4-carboxylic acid propyl ester
  参考文献：
  名称：

  Medard, Bulletin de la Societe Chimique de France, 1936, vol. <5> 3, p. 1343,1345

  摘要：

  DOI：

文献信息

• Carbon dioxide utilization in the efficient synthesis of carbamates by deep eutectic solvents (DES) as green and attractive solvent/catalyst systems
  作者：Iman Dindarloo Inaloo、Sahar Majnooni

  DOI：10.1039/c9nj02810b

  日期：——

  green and eco-friendly solvent/catalyst system based on a deep eutectic solvent (DES) was devised and developed for the simple synthesis of carbamates through three-component coupling of amines, alkyl halides and carbon dioxide (CO2). It was found that choline chloride:zinc(II) chloride ([ChCl][ZnCl2]2) was very proficient and effective for the activation and utilization of CO2 in carbamate formation

  设计和开发了一种基于深共熔溶剂（DES）的绿色环保型溶剂/催化剂体系，用于通过胺，烷基卤化物和二氧化碳（CO 2）的三组分偶联来简单合成氨基甲酸酯。已经发现，胆碱氯化物：氯化锌（II）（[ChCl] [ZnCl 2 ] 2）对于由多种胺形成氨基甲酸酯的反应中的CO 2的活化和利用非常有效和有效。出人意料的是，该策略在室温下在大气CO 2压力下提供了所需的氨基甲酸酯。特别地，芳族和脂族胺都是有效的，并显示出优异的收率。此外，[ChCl] [ZnCl2 ] 2具有很高的稳定性，也可以重复使用至少五个连续的周期，而不会造成任何明显的活性损失。值得注意的是，这是第一个可以从反应混合物中成功回收的溶剂/催化剂体系。
• INDAZOLE ACRYLIC ACID AMIDE COMPOUND
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2192116A1

  公开（公告）日：2010-06-02

  A compound of the formula; wherein ring X is benzene or pyridine; R1 is substituted alkyl; R2 is optionally substituted aryl or optionally substituted heterocyclic group; R3 is hydrogen or alkyl,; R4 is hydrogen, halogen or alkyl; R5 is hydrogen or alkyl; R6 and R7 are the same or different and each hydrogen or halogen, or a pharmaceutically acceptable salt thereof, which is useful as IKur blocker effective for preventing or treating cardiac arrhythmia such as atrial fibrillation.

  式中的化合物； 其中环 X 是苯或吡啶；R1 是取代的烷基；R2 是任选取代的芳基或任选取代的杂环基团；R3 是氢或烷基；R4 是氢、卤素或烷基；R5 是氢或烷基；R6 和 R7 相同或不同且各自是氢或卤素，或其药学上可接受的盐，可作为 IKur 阻滞剂有效地预防或治疗心律失常，如心房颤动。
• NON-AQUEOUS ELECTROLYTE SOLUTION ADDITIVE, NON-AQUEOUS ELECTROLYTE SOLUTION FOR LITHIUM SECONDARY BATTERY AND LITHIUM SECONDARY BATTERY, COMPRISING NON-AQUEOUS ELECTROLYTE SOLUTION ADDITIVE
  申请人：LG Chem, Ltd.

  公开号：EP3518334A1

  公开（公告）日：2019-07-31

  The present invention relates to a non-aqueous electrolyte solution additive, and a non-aqueous electrolyte solution for a lithium-ion battery and a lithium-ion battery which include the same, and particularly, to a non-aqueous electrolyte solution, which may remove an acid generated by the decomposition of a lithium salt while being able to suppress the dissolution of metal impurities causing failure in the battery by using and including a Lewis base compound containing a propargyl group as a non-aqueous electrolyte solution additive for a lithium-ion battery, and a lithium secondary battery in which transition metal dissolution in a positive electrode and a low-voltage phenomenon are improved.

  本发明涉及一种非水电解质溶液添加剂、一种用于锂离子电池的非水电解质溶液和一种包含该添加剂的锂离子电池，特别是涉及一种非水电解质溶液、通过使用和包括含有丙炔基团的路易斯碱化合物作为锂离子电池的非水电解质溶液添加剂，可去除锂盐分解产生的酸，同时能够抑制导致电池失效的金属杂质的溶解，以及改善正极中过渡金属溶解和低电压现象的锂二次电池。
• Stabilized protease composition comprising a serine protease, morpholino derivatives and reversible inhibitors of said serine protease
  申请人：Trobio AB

  公开号：EP1637141B1

  公开（公告）日：2011-11-16
• ALKOXY SUBSTITUTED IMIDAZOQUINOLINES
  申请人：3M Innovative Properties Company

  公开号：EP1673087A2

  公开（公告）日：2006-06-28