N-tetradecyl-γ-hydroxy-butyric acidamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-tetradecyl-γ-hydroxy-butyric acidamide
• 英文别名: N-tetradecyl-γ-hydroxybutyric acid amide；N-(4-hydroxybutanoyl)tetradecylamine；4-hydroxy-N-myristylbutyramide；N-tetradecyl-gamma-hydroxybutyric acid amide；4-hydroxy-N-tetradecylbutanamide
• 化学式: C₁₈H₃₇NO₂
• 分子量: 299.497
• InChiKey: VTPIZPTWODRDNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  γ-丁内酯 、 十四胺 以 1,4-二氧六环 为溶剂， 生成 N-tetradecyl-γ-hydroxy-butyric acidamide
  参考文献：
  名称：

  由可溶性两亲物及其不溶性二维凝聚同系物组成的混合单层动力学

  摘要：

  实验和理论研究了由可溶性定制两亲物 N-癸基-γ-羟基丁酸酰胺 (C10NH) 及其不溶性缩合同系物 N-十四烷基-γ-羟基丁酸酰胺 (C14NH) 组成的混合单分子层的动力学。对可溶性C10NH和不溶性C14NH的单组分和混合单分子层进行了实验研究，并将结果与​​理论预测进行了比较。对于一些理论模型，导出了不溶性和可溶性同系物混合单层的状态方程和可溶性两亲物的吸附等温线方程。假设混合单层压缩过程中可溶性组分解吸的扩散动力学，可溶性两亲物的表面浓度（吸附）的新方程允许人们根据单层压缩、浓度和其他参数的条件来分析该值。混合物的非理想性对面积变化的影响...

  DOI：

  10.1021/jp020035g

文献信息

• Studies on Crude Drugs Effective on Visceral Larva Migrans. Part XVI. Nematocidal Activity of Long Alkyl Chain Amides, Amines, and Their Derivatives on Dog Roundworm Larvae.
  作者：Fumiyuki KIUCHI、Satomi NISHZAWA、Hiromi KAWANISHI、Sayuri KINOSHITA、Hisanao OHSIMA、Akiyo UCHITANI、Noriko SEKINO、Miki ISHIDA、Kaoru KONDO、Yoshisuke TSUDA

  DOI：10.1248/cpb.40.3234

  日期：——

  activity of amides and amines having a long alkyl chain against the second-stage larva of dog roundworm, Toxocara canis, was examined. Long chain acyl amides with smaller substituents on the nitrogen showed stronger activity and the activity of cyclic amine amides was stronger than that of acyclic ones. In a series of homologous amides, the activity was dependent on the alkyl chain length: it reached

  检查了具有长烷基链的酰胺和胺对犬round虫第二阶段幼虫的杀线虫活性。在氮上具有较小取代基的长链酰基酰胺显示出更强的活性，环状胺酰胺的活性强于无环酰胺。在一系列同源酰胺中，活性取决于烷基链长：在最佳链长处达到最大值，而在较短和较长的同系物中均降低。通过使用双线性模型分析了同系物的活性与疏水性之间的关系。对于所有中性酰胺，提供最大活性的化合物的疏水性均相似，但分子中具有额外胺基的酰胺具有不同的值。具有长烷基链的叔胺及其盐也具有与相应酰胺相当的杀线虫活性。这些盐以低于其临界胶束浓度的浓度杀死幼虫，表明它们表现为杀线虫作用的单个分子。
• COSMETIC BASE INCLUDING AMIDE ALCOHOL, AND COSMETIC
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：US20190343745A1

  公开（公告）日：2019-11-14

  The purpose of the present invention is to provide a novel amide alcohol that can be used as a cosmetic base ingredient. An amide alcohol represented by formula (I).

  本发明的目的是提供一种可用作化妆品基础成分的新型酰胺醇。一种由式（I）所表示的酰胺醇。
• CONDITIONING AGENT AND CONDITIONING COMPOSITION
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：EP3479815A1

  公开（公告）日：2019-05-08

  [Problem] An object of the invention is to provide a conditioning agent and a conditioning composition which are excellent in adsorptivity to fibers, hair, skin, etc. and impart smoothness thereto. [Solving means] A conditioning agent comprising an amide alcohol represented by formula (I).

  [问题] 本发明的目的是提供一种调理剂和调理组合物，它们对纤维、头发、皮肤等具有极佳的吸附性，并能赋予其柔滑感。 [解决方法] 由式 (I) 所代表的酰胺醇组成的护理剂。
• Cosmetic base including amide alcohol, and cosmetic
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：US11083677B2

  公开（公告）日：2021-08-10

  The purpose of the present invention is to provide a novel amide alcohol that can be used as a cosmetic base ingredient. An amide alcohol represented by formula (I).

  本发明的目的是提供一种可用作化妆品基础成分的新型酰胺醇。由式（I）代表的酰胺醇。
• Kinetics of two-dimensional phase transition of amphiphilic monolayers at the air/water interface
  作者：V. B. Fainerman、D. Vollhardt、V. Melzer

  DOI：10.1063/1.474371

  日期：1997.7

  A theoretical model is developed which describes the adsorption kinetics of the two-dimensional first-order phase transition in an adsorption layer. The theory includes a kinetic model of the phase transition in Langmuir and Gibbs monolayers, the adsorption from bulk solution, and the dissociation kinetics of bulk micelles. The theory describes well the experimental results of the adsorption kinetics of the amphiphile N-dodecyl-hydroxy-butyric acidamide dissolved in the aqueous bulk phase. The inflection point of dynamic surface pressure curves corresponds to the first-order phase transition in the adsorption layer. The rate constants for the 2D aggregation in the adsorption layer and the bulk micelle formation are calculated. The relaxation time of the 2D aggregation is approximately ten times lower than that of the association/dissociation of bulk micelles.