亚丙基二肉豆蔻酸酯 | 51209-16-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 亚丙基二肉豆蔻酸酯
• 中文别名: 败脂酸,丁基2-甲基丙-2-烯酸酯,乙基2-甲基丙-2-烯酸酯
• 英文名称: 1,2-bis-myristoyloxy-propane
• 英文别名: 1,2-Bis-myristoyloxy-propan；propylene glycol dimyristate；Propylene dimyristate；2-tetradecanoyloxypropyl tetradecanoate
• CAS: 51209-16-6
• 化学式: C₃₁H₆₀O₄
• 分子量: 496.815
• InChiKey: NRRPJRVSNIJDAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.9
• 重原子数：
  35
• 可旋转键数：
  29
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2915900090

反应信息

• 作为产物：
  描述：

  1,2-丙二醇 、 肉豆蔻酰氯 在 吡啶 作用下， 生成 亚丙基二肉豆蔻酸酯
  参考文献：
  名称：

  Staudinger; Schwalenstoecker, Chemische Berichte, 1935, vol. 68, p. 729

  摘要：

  DOI：

文献信息

• [EN] BRANCHED TAIL LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSÉS LIPIDIQUES À QUEUE RAMIFIÉE ET COMPOSITIONS POUR L'ADMINISTRATION INTRACELLULAIRE D'AGENTS THÉRAPEUTIQUES
  申请人：MODERNATX INC

  公开号：WO2022204288A1

  公开（公告）日：2022-09-29

  The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

  该披露涉及新型脂质及其组成物。脂质纳米粒子（例如，空的LNPs或载荷的LNPs）包括一种新型脂质以及其他脂质，例如磷脂、结构脂质和PEG脂质。脂质纳米粒子（例如，空的LNPs或载荷的LNPs）还包括治疗和/或预防措施，例如RNA，可用于将治疗和/或预防措施传递到哺乳动物细胞或器官中，以调节多肽、蛋白质或基因表达。
• Cell growth accelerator containing polyphosphoric acid and cell growth method using the same
  申请人：Nissho Corporation

  公开号：EP0987324A2

  公开（公告）日：2000-03-22

  Provided are a cell growth accelerator containing a polyphosphoric acid and a cell growth method in which cells are grown by adding the cell growth accelerator to a medium for cells of animals and plants or by using a glass or plastic cell cultivator containing or coated with the cell growth accelerator. When substances are produced in vitro using culture cells, the cell culture and the cell growth acceleration are conducted at low costs safely and efficiently by adding the cell growth accelerator containing the polyphosphoric acid to the medium for cells of animals and plants or by using the cell cultivator containing or coated with the cell growth accelerator.

  本发明提供了一种含有多磷酸的细胞生长促进剂和一种细胞生长方法，通过在动植物细胞培养基中加入细胞生长促进剂或使用含有或涂覆有细胞生长促进剂的玻璃或塑料细胞培养器来培养细胞。 当使用培养细胞在体外生产物质时，通过在动植物细胞培养基中加入含有多磷酸的细胞生长促进剂，或使用含有或涂有细胞生长促进剂的细胞培养器，可以安全、高效、低成本地进行细胞培养和细胞生长加速。
• Emulgierende Suppositoriengrundmassen und daraus hergestellte Zäpfchen
  申请人：Henkel Kommanditgesellschaft auf Aktien

  公开号：EP0283977B1

  公开（公告）日：1991-07-31
• DOUBLE-STRANDED LIPID-MODIFIED RNA HAVING HIGH RNA INTERFERENCE EFFECT
  申请人：Kubo Takanori

  公开号：US20110034545A1

  公开（公告）日：2011-02-10

  An object of the present invention is to provide a novel double-stranded RNA that has high resistance to nuclease and cellular uptake efficiency and that can produce an excellent RNA interference effect. The present invention provides a double-stranded lipid-modified RNA comprising a sense strand having a nucleotide sequence complementary to a target sequence in a target gene, and an antisense strand having a nucleotide sequence complementary to the sense strand, the double-stranded RNA being capable of suppressing the expression of the target gene, and the sense strand having a double-stranded lipid bound directly or via a linker to at least one of the first to sixth nucleotides from the 5′ end.
• LIPID PARTICLE, NUCLEIC ACID TRANSFER CARRIER, COMPOUND FOR MANUFACTURING NUCLEIC ACID TRANSFER CARRIER, METHOD FOR MANUFACTURING LIPID PARTICLE, AND GENE TRANSFER METHOD
  申请人：FUJIFILM Corporation

  公开号：US20150004695A1

  公开（公告）日：2015-01-01

  The present invention provides a lipid particle which has low cytotoxicity, can stably hold a nucleic acid molecule outside a cell (in blood), and can escape from an endosome and rapidly release the nucleic acid in the cytoplasm; a nucleic acid transfer carrier; a compound for manufacturing a nucleic acid transfer carrier; a method for manufacturing a lipid particle; and a gene transfer method. The lipid particle contains, as constituents, a phospholipid having one or more amino groups and one or more nitrogen-containing heterocyclic groups, a neutral lipid not containing a nitrogen-containing heterocyclic group, a sterol, and a nucleic acid.