4-diallylamino-1H-pyrrole-2-carboxylic asid benzyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-diallylamino-1H-pyrrole-2-carboxylic asid benzyl ester
• 英文别名: benzyl 4-[bis(prop-2-enyl)amino]-1H-pyrrole-2-carboxylate
• 化学式: C₁₈H₂₀N₂O₂
• 分子量: 296.369
• InChiKey: RQUISATXJMOJEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  45.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  benzyl N-(9-phenyl-9-fluorenyl)-4-oxoprolinate 、 二烯丙基胺 在 对甲苯磺酸 作用下， 以 四氢呋喃 为溶剂， 以76%的产率得到4-diallylamino-1H-pyrrole-2-carboxylic asid benzyl ester
  参考文献：
  名称：

  An Effective New Synthesis of 4-Aminopyrrole-2-carboxylates

  摘要：

  [GRAPHICS]A series of 4-amino-1H-pyrrole-2-carboxylic acid benzyl esters has been synthesized in 61-84% yields on treatment of N-PhF-4-oxoproline benzyl ester and its 3-alkyl-substituted derivatives with different primary and secondary amines and a catalytic amount of TsOH in THE 4-Hydroxy-1H-pyrrole-2-carboxylic acid benzyl esters were prepared in 59 and 70% yields by treatment of N-PhF-4-oxoproline benzyl esters with ammonium hydroxide in THF.

  DOI：

  10.1021/ol0262690

文献信息

• An Effective New Synthesis of 4-Aminopyrrole-2-carboxylates
  作者：Félix-Antoine Marcotte、William D. Lubell

  DOI：10.1021/ol0262690

  日期：2002.7.1

  [GRAPHICS]A series of 4-amino-1H-pyrrole-2-carboxylic acid benzyl esters has been synthesized in 61-84% yields on treatment of N-PhF-4-oxoproline benzyl ester and its 3-alkyl-substituted derivatives with different primary and secondary amines and a catalytic amount of TsOH in THE 4-Hydroxy-1H-pyrrole-2-carboxylic acid benzyl esters were prepared in 59 and 70% yields by treatment of N-PhF-4-oxoproline benzyl esters with ammonium hydroxide in THF.