2-(2-methoxyethoxy)-ethylbenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2-methoxyethoxy)-ethylbenzene
• 英文别名: 1-Ethyl-2-(2-methoxyethoxy)benzene
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: GLEZTQZSCMITMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-methoxyethoxy)-ethylbenzene 在 aluminium(III) iodide 作用下， 以 甲苯 为溶剂， 以62%的产率得到乙基苯酚
  参考文献：
  名称：

  New stabilising groups for lateral lithiation of ortho-cresol derivatives

  摘要：

  1 -(2-Methoxyethoxy) -2-methyl benzene and 1-(2-dimethylaminoethoxy)-2-methylbenzene have been lithiated using seeBuLi under a variety of conditions and the laterally lithiated species trapped with electrophiles. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.070
• 作为产物：
  描述：

  1-(2-甲氧基乙氧基)-2-甲基苯 、 碘甲烷 在 仲丁基锂 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 2-(2-methoxyethoxy)-ethylbenzene 、 2-(2-methoxyethoxy)-1,3-dimethylbenzene
  参考文献：
  名称：

  New stabilising groups for lateral lithiation of ortho-cresol derivatives

  摘要：

  1 -(2-Methoxyethoxy) -2-methyl benzene and 1-(2-dimethylaminoethoxy)-2-methylbenzene have been lithiated using seeBuLi under a variety of conditions and the laterally lithiated species trapped with electrophiles. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.070

文献信息

• TRIAZOLE ACC INHIBITORS AND USES THEREOF
  申请人：Gilead Apollo, LLC

  公开号：US20170166584A1

  公开（公告）日：2017-06-15

  The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了三唑化合物，可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及其组合物和使用方法。
• Substituted Piperidines that Increase P53 Activity and the Uses Thereof
  申请人：Ma Yao

  公开号：US20080004287A1

  公开（公告）日：2008-01-03

  In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

  在其多种实施形式中，本发明披露了作为HDM2蛋白抑制剂的新型化合物，制备这种化合物的方法，包括一种或多种这种化合物的药物组合物，以及利用这种化合物或药物组合物进行与HDM2蛋白或P53相关的一种或多种疾病的治疗、预防、抑制方法。
• Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof
  申请人：Crinetics Pharmaceuticals, Inc.

  公开号：US10604507B2

  公开（公告）日：2020-03-31

  Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.

  本文描述了黑色素皮质素亚型-2 受体（MC2R）调节剂化合物、制造此类化合物的方法、包含此类化合物的药物组合物和药物，以及使用此类化合物治疗可从调节 MC2R 活性中获益的病症、疾病或紊乱的方法。
• Pyrazole ACC inhibitors and uses thereof
  申请人：Gilead Apollo, LLC

  公开号：US10941158B2

  公开（公告）日：2021-03-09

  The present invention provides pyrazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了可用作乙酰辅酶羧化酶（ACC）抑制剂的吡唑化合物、其组合物以及使用方法。
• New stabilising groups for lateral lithiation of ortho-cresol derivatives and a new route to 2-substituted chromans
  作者：James A. Wilkinson、Eun-Ang Raiber、Sylvie Ducki

  DOI：10.1016/j.tet.2008.04.093

  日期：2008.6

  2-(2-Methoxyethoxy)-toluene and 2-(2-dimethylaminoetlioxy)-toluene have been lithiated using sec-BuLi under a variety of conditions and the laterally lithiated species trapped with electrophiles, including but-1-ene oxide, leading to a new synthesis of 2-ethylchroman. (C) 2008 Elsevier Ltd. All rights reserved.