2-tert-butyl-6,7-dimethoxy-3-phenyl-1-(trifluoromethyl)-1,2-dihydroisoquinoline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-tert-butyl-6,7-dimethoxy-3-phenyl-1-(trifluoromethyl)-1,2-dihydroisoquinoline
• 化学式: C₂₂H₂₄F₃NO₂
• 分子量: 391.433
• InChiKey: IGWRXVNWRYKBIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.92
• 重原子数：
  28.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  21.7
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  N-[4,5-dimethoxy-2-(phenylethynyl)benzylidene]-tert-butylamine 、 (三氟甲基)三甲基硅烷 在 silver hexafluoroantimonate 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 以90%的产率得到2-tert-butyl-6,7-dimethoxy-3-phenyl-1-(trifluoromethyl)-1,2-dihydroisoquinoline
  参考文献：
  名称：

  Generation of 1-(trifluoromethyl)-1,2-dihydroisoquinolines via a silver(I)-catalyzed reaction of 2-alkynylaryl aldimine with trimethyl(trifluoromethyl)silane

  摘要：

  A silver(I)-catalyzed reaction of 2-alkynylaryl aldimine with trimethyl(trifluoromethyl)silane is reported. This reaction proceeds efficiently under extremely mild conditions to generate 1-(trifluoromethyl)-1,2-dihydroisoquinolines in good yields. A three-component reaction of 2-alkynylbenzaldehyde, amine, with trimethyl(trifluoromethyl)silane is presented as well. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.12.064

文献信息

• Generation of 1-(trifluoromethyl)-1,2-dihydroisoquinolines via a silver(I)-catalyzed reaction of 2-alkynylaryl aldimine with trimethyl(trifluoromethyl)silane
  作者：Xianbo Wang、Guanyinsheng Qiu、Ling Zhang、Jie Wu

  DOI：10.1016/j.tetlet.2013.12.064

  日期：2014.1

  A silver(I)-catalyzed reaction of 2-alkynylaryl aldimine with trimethyl(trifluoromethyl)silane is reported. This reaction proceeds efficiently under extremely mild conditions to generate 1-(trifluoromethyl)-1,2-dihydroisoquinolines in good yields. A three-component reaction of 2-alkynylbenzaldehyde, amine, with trimethyl(trifluoromethyl)silane is presented as well. (C) 2013 Elsevier Ltd. All rights reserved.