2-{2-allyl-5-(trifluoromethyl)phenyl}pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-{2-allyl-5-(trifluoromethyl)phenyl}pyridine
• 英文别名: 2-[2-Prop-2-enyl-5-(trifluoromethyl)phenyl]pyridine
• 化学式: C₁₅H₁₂F₃N
• 分子量: 263.262
• InChiKey: KAZRJUFLZNHPPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酸烯丙酯 、 2-(3-trifluoromethylphenyl)pyridine 在 silver hexafluoroantimonate 、 [Cp*Co(CO)I₂] 、 potassium acetate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 以61%的产率得到2-{2-allyl-5-(trifluoromethyl)phenyl}pyridine
  参考文献：
  名称：

  Cobalt(III)-Catalyzed Allylation with Allyl Acetates by C–H/C–O Cleavage

  摘要：

  Versatile cobalt-catalyzed C-H allylations on arenes, indoles, and pyrroles were accomplished with allyl acetates. The C-H/C-O functionalization process was characterized by a broad substrate scope as well as an excellent functional-group tolerance and was shown to occur by initial C-H cobaltation.

  DOI：

  10.1055/s-0034-1379927

文献信息

• Cobalt(III)-Catalyzed Allylation with Allyl Acetates by C–H/C–O Cleavage
  作者：Lutz Ackermann、Marc Moselage、Nicolas Sauermann、Julian Koeller、Weiping Liu、Dmitri Gelman

  DOI：10.1055/s-0034-1379927

  日期：——

  Versatile cobalt-catalyzed C-H allylations on arenes, indoles, and pyrroles were accomplished with allyl acetates. The C-H/C-O functionalization process was characterized by a broad substrate scope as well as an excellent functional-group tolerance and was shown to occur by initial C-H cobaltation.