PCM-0102782

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: PCM-0102782
• 英文别名: 2-chloro-N-(1-cyano-1-methylethyl)-N-methylacetamide；2-chloro-N-(2-cyanopropan-2-yl)-N-methylacetamide
• 化学式: C₇H₁₁ClN₂O
• mdl: MFCD13195794
• 分子量: 174.63
• InChiKey: YXMRZCNUPULPAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Benzimidazole derivatives and their uses
  申请人：TEIJIN PHARMA LIMITED

  公开号：US11332459B2

  公开（公告）日：2022-05-17

  The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

  本发明涉及瞬时受体电位通道 6（TRPC6）蛋白活性的抑制剂。本发明提供了式(I)化合物或其药学上可接受的盐、包含本发明化合物的药物组合物、制造本发明化合物的方法及其治疗用途。
• DICYANO ALKANOIC ACID AMIDES FOR COMBATING ANIMAL PESTS
  申请人：BASF SE

  公开号：EP1916895A1

  公开（公告）日：2008-05-07
• Dicyano Alkanoic Acid Amides for Combating Animal Pests
  申请人：Hofmann Michael

  公开号：US20080227635A1

  公开（公告）日：2008-09-18

  Dicyano alkanoic acid amides of formula (I), wherein R 1 is H, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, or haloalkynyl; R 2 is H, CN, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkoxy, or haloalkoxy; R 3 and R 4 are H, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, cycloalkenyl, halocycloalkenyl, or R 3 and R 4 together can be alkylene, haloalkylene, alkenylene or haloalkenylene; X is O or S; R 5 and R 6 are H, alkyl, optionally substituted with 1 to 3 groups CN, NO 2 , OH, NR 7 R 8 , alkoxy, haloalkoxy, alkylthio, haloalkylthio, cycloalkyl, halocycloalkyl and optionally substituted phenyl; or haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, NR 7 R 8 , alkoxycarbonyl, haloalkoxycarbonyl, alkenyloxycarbonyl, haloalkenyloxycarbonyl, alkylcarbonyl, haloalkylcarbonyl, R 7 R 8 N—C(═O)—, phenylcarbonyl, benzylcarbonyl or phenyl wherein phenylcarbonyl, benzylcarbonyl and phenyl are optionally substituted; or R 5 and R 6 are a saturated, partially unsaturated or unsaturated 5- to 6-membered heterocyclic radical which may contain 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur and which radical may be bonded via a carbonyl (C(═O)) linkage, and which radical is optionally substituted; R 7 , R 8 are H, alkyl, haloalkyl, alkylcarbonyl, haloalkylcarbonyl, benzyl, phenyl, phenylcarbonyl, alkylsulfonyl, or haloalkylsulfonyl; or the enantiomers or diastereomers or salts thereof, processes for the preparation of compounds of formula (I), use of compounds of formula (I) for combating insects, acarids, or nematodes, and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites using compounds of formula (I).
• BENZIMIDAZOLE DERIVATIVES AND THEIR USES
  申请人：Amgen Inc.

  公开号：US20200308145A1

  公开（公告）日：2020-10-01

  The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
• [EN] DICYANO ALKANOIC ACID AMIDES FOR COMBATING ANIMAL PESTS<br/>[FR] AMIDES D'ACIDES DICYANOALCANOÏQUES SERVANT À LUTTER CONTRE DES ANIMAUX NUISIBLES
  申请人：BASF AG

  公开号：WO2007014899A1

  公开（公告）日：2007-02-08

  [EN] Dicyano alkanoic acid amides of formula (I), wherein R¹ is H, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, or haloalkynyl; R² is H, CN, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkoxy, or haloalkoxy; R³ and R⁴ are H, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, cycloalkenyl, halocycloalkenyl, or R³ and R⁴ together can be alkylene, haloalkylene, alkenylene or haloalkenylene; X is O or S; R⁵ and R⁶ are H, alkyl, optionally substituted with 1 to 3 groups CN, NO₂, OH, NR⁷R⁸, alkoxy, haloalkoxy, alkylthio, haloalkylthio, cycloalkyl, halocycloalkyl and optionally substituted phenyl; or haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, NR⁷R⁸, alkoxycarbonyl, haloalkoxycarbonyl, alkenyloxycarbonyl, haloalkenyloxycarbonyl, alkylcarbonyl, haloalkylcarbonyl, R⁷R⁸N-C(=O)-, phenylcarbonyl, benzylcarbonyl or phenyl wherein phenylcarbonyl, benzylcarbonyl and phenyl are optionally substituted; or R⁵ and R⁶ are a saturated, partially unsaturated or unsaturated 5- to 6-membered heterocyclic radical which may contain 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur and which radical may be bonded via a carbonyl (C(=O)) linkage, and which radical is optionally substituted; R⁷, R⁸ are H, alkyl, haloalkyl, alkylcarbonyl, haloalkylcarbonyl, benzyl, phenyl, phenylcarbonyl, alkylsulfonyl, or haloalkylsulfonyl; or the enantiomers or diastereomers or salts thereof, processes for the preparation of compounds of formula (I), use of compounds of formula (I) for combating insects, acarids, or nematodes, and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites using compounds of formula (I).
  [FR] Amides d'acides dicyanoalcanoïques de formule (I), dans laquelle R¹ est H, un alkyle, un haloalkyle, un alcényle, un haloalcényle, un alcynyle ou un haloalcynyle ; R² est H, CN, un alkyle, un haloalkyle, un alcényle, un haloalcényle, un alcynyle, un haloalcynyle, un cycloalkyle, un 10 halocycloalkyle, un alcoxy ou un haloalcoxy ; R³ et R⁴ sont chacun H, un alkyle, un haloalkyle, un alcényle, un haloalcényle, un alcynyle, un haloalcynyle, un cycloalkyle, un halocycloalkyle, un cycloalcényle, un halocycloalcényle ou bien R³ et R⁴ peuvent être ensemble un alkylène, un haloalkylène, un alcénylène ou un haloalcénylène ; X est O ou S ; R⁵ et R⁶ sont chacun H, un alkyle, facultativement substitué par 1 à 3 groupes CN, NO₂, OH, NR⁷R⁸, alcoxy, haloalcoxy, alkylthio, haloalkylthio, cycloalkyles, halocycloalkyles et phényles facultativement substitués ; ou un haloalkyle, un cycloalkyle, un halocycloalkyle, un alcényle, un haloalcényle, un alcynyle, un haloalcynyle, un alkylsulfinyle, un haloalkylsulfinyle, un alkylsulfonyle, un haloalkylsulfonyle, NR⁷R⁸, un alcoxycarbonyle, un haloalcoxycarbonyle, un alcényloxycarbonyle, un haloalcényloxycarbonyle, un alkylcarbonyle, un haloalkylcarbonyle, R⁷R⁸N-C(=O)-, un phénylcarbonyle, un benzylcarbonyle ou un phényle, le phénylcarbonyle, le benzylcarbonyle et le phényle étant chacun facultativement substitués ; ou bien R⁵ et R⁶ sont chacun un radical hétérocyclique à 5 ou 6 chaînons saturé, partiellement insaturé ou insaturé qui peut contenir 1 à 4 hétéroatomes sélectionnés entre l'oxygène, l'azote et le soufre et lequel radical pouvant être lié via une liaison carbonyle (C(=O)) et lequel radical étant facultativement substitué ; R⁷, R⁸ sont chacun H, un alkyle, un haloalkyle, un alkylcarbonyle, un haloalkylcarbonyle, un benzyle, un phényle, un phénylcarbonyle, un alkylsulfonyle ou un haloalkylsulfonyle ; ou énantiomères ou diastéréoisomères ou sels de ceux-ci ; procédés pour la préparation des composés de formule (I) ; utilisation des composés de formule (I) pour lutter contre des insectes, des acariens ou des nématodes ; et procédé servant à traiter ou à protéger des animaux contre une infestation ou une infection par des parasites ou procédé servant à lutter contre ladite infestation ou infection par des parasites ou à prévenir celle-ci en utilisant les composés de formule (I).