(E)-3-(furan-2-yl)-1-(3-methoxyphenyl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-3-(furan-2-yl)-1-(3-methoxyphenyl)prop-2-en-1-one
• 英文别名: 3t-[2]furyl-1-(3-methoxy-phenyl)-propenone；3t-[2]Furyl-1-(3-methoxy-phenyl)-propenon；(2E)-3-(furan-2-yl)-1-(3-methoxyphenyl)prop-2-en-1-one
• 化学式: C₁₄H₁₂O₃
• 分子量: 228.247
• InChiKey: HPIYSJKWTRZTST-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  间甲氧基苯甲酰氯 在 甲醇 、 sodium methylate 作用下， 生成 (E)-3-(furan-2-yl)-1-(3-methoxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Experimental laser destruction of trigeminal sensory root

  摘要：

  The possibility of local laser destruction of the trigeminal sensory root by a puncture technique is demonstrated. A fibrous scar was formed on a limited area of the trigeminal root. There were no signs of axonal regeneration, posttraumatic neuroma, or considerable changes in the Meekel sinus.

  DOI：

  10.1007/bf02434888

文献信息

• Screening of Biological Activities of a Series of Chalcone Derivatives against Human Pathogenic Microorganisms
  作者：İsa Karaman、Hayreddin Gezegen、M. Burcu Gürdere、Alparslan Dingil、Mustafa Ceylan

  DOI：10.1002/cbdv.200900027

  日期：2010.2

  In an effort to develop new antimicrobial agents, a series of chalcone derivatives, 3-60, were prepared by Claisen-Schmidt condensation of appropriate acetophenones and 2-furyl methyl ketones with appropriate aromatic aldehydes, furfural, and thiophene-2-carbaldehyde in an aqueous solution of NaOH and EtOH at room temperature. The synthesized compounds were characterized by means of their IR- and NMR-spectral

  为了开发新的抗菌剂，通过Claisen-Schmidt将适当的苯乙酮和2-呋喃基甲基酮与适当的芳族醛，糠醛和噻吩-2-甲醛缩合制备了一系列查尔酮衍生物3-60。室温下的NaOH和EtOH水溶液。合成的化合物通过其IR和NMR光谱数据以及元素分析进行​​表征。通过盘扩散法测试所有化合物的抗菌和抗真菌活性。对于活性最高的化合物，还确定了最低抑菌浓度（MIC）。
• Synthesis and Anti-Bacterial Activity of Some Heterocyclic Chalcone Derivatives Bearing Thiofuran, Furan, and Quinoline Moieties
  作者：Chang-Ji Zheng、Sheng-Ming Jiang、Zhen-Hua Chen、Bai-Jun Ye、Hu-Ri Piao

  DOI：10.1002/ardp.201100005

  日期：2011.10

  36 Novel heterocyclic chalcone derivatives were synthesized and tested for their anti‐bacterial activity. Some compounds presented good anti‐microbial activities against Gram‐positive bacteria (including the multidrug‐resistant clinical isolates). This class of compounds presented high potency against Streptococcus mutans, among which the derivatives F2 with an MIC of 2 µg/mL was as active as the standard

  合成了 36 种新型杂环查耳酮衍生物并测试了它们的抗菌活性。一些化合物对革兰氏阳性菌（包括耐多药临床分离株）具有良好的抗菌活性。这类化合物对变形链球菌表现出高效能，其中MIC为2 µg/mL的衍生物F2与标准药物（诺氟沙星）活性相同，但活性低于苯唑西林。所有化合物在 64 µg/mL 时均不抑制革兰氏阴性菌（大肠杆菌 CCARM 1924 或大肠杆菌 CCARM 1356）的生长。
• Studies of NMR Chemical Shifts of Chalcone Derivatives of Five‐membered Monoheterocycles and Determination of Aromaticity Indices
  作者：Eun Jeong Jeong、In‐Sook Han Lee

  DOI：10.1002/bkcs.11749

  日期：2019.7

  (E)‐1‐heteroaryl‐3‐arylpropen‐1‐ones. The 13C chemical shift values (δC) of the chalcone derivatives were determined in order to find if they correlated with the Hammett σ values. A good correlation, especially for the β‐C for both series, was found for the 13C chemical shift values (δC) of the chalcone derivatives with the Hammett σ values. The chemical shift values of the β‐C of the heterocyclic compounds

  通过将噻吩，吡咯和呋喃的相应醛与m-和n-醛缩醛缩合制得五元单杂环化合物的一系列查耳酮衍生物（E）-1-芳基-3-杂芳基丙烯-1-酮对位取代的苯乙酮。杂环的乙酰基化合物与m和p取代的苯甲醛的类似缩合产生了另一系列查尔酮衍生物，（E）-1-杂芳基-3-芳基丙-1-酮。在13 c。化学位移值（δ Ç确定查尔酮衍生物的），以查明它们是否与Hammettσ值相关。一个很好的相关性，特别是对β-C为两个系列，被发现为13 c。化学位移值（δ ç与哈米特σ值的查耳酮衍生物的）。绘制了杂环化合物β-C的化学位移值与苯衍生物的化学位移值的关系图。发现所得的斜率接近芳香性指数的值。
• Phosphate transport inhibitors
  申请人：Jozefiak H. Thomas

  公开号：US20070021509A1

  公开（公告）日：2007-01-25

  Disclosed are compounds which have been identified as inhibitors of phosphate transport. Many of the compounds are represented by Structural Formula (I): Ar 1 —W—X—Y—Ar 2 ; or a pharmaceutically acceptable salt thereof. Ar 1 and Ar 2 are independently a substituted or unsubstituted aryl group or an optionally substituted five membered or six membered non-aromatic heterocylic group fused to an optionally substituted monocylic aryl group. W and Y are independently a covalent bond or a C1-C3 substituted or unsubstituted alkylene group. X is a heteroatom-containing functional group, an aromatic heterocyclic group, substituted aromatic heterocyclic group, non-aromatic heterocyclic group, substituted non-aromatic heterocyclic group, an olefin group or a substituted olefin group. Also disclosed are methods of treating a subject with a disease associated with hyperphosphatemia, as well as a disease mediated by phosphate-transport function. The methods comprise the step of administering an effective amount of the one of the compounds described above.

  本发明涉及已被鉴定为磷酸盐转运抑制剂的化合物。其中许多化合物由结构式（I）表示：Ar1-W-X-Y-Ar2；或其药学上可接受的盐。其中，Ar1和Ar2独立地为取代或未取代的芳基团或可选取代的五元或六元非芳基杂环团与可选取代的单环芳基团融合。W和Y独立地为共价键或C1-C3取代或未取代的烷基链。X为含杂原子的官能团、芳基杂环团、取代的芳基杂环团、非芳基杂环团、取代的非芳基杂环团、烯烃基或取代的烯烃基。本发明还涉及治疗与高磷血症相关的疾病以及由磷酸盐转运功能介导的疾病的方法。该方法包括给予上述化合物之一的有效量。
• Experimental laser destruction of trigeminal sensory root
  作者：R. U. Giniatullin、A. I. Kozel'、S. T. Ismagilova

  DOI：10.1007/bf02434888

  日期：2000.6

  The possibility of local laser destruction of the trigeminal sensory root by a puncture technique is demonstrated. A fibrous scar was formed on a limited area of the trigeminal root. There were no signs of axonal regeneration, posttraumatic neuroma, or considerable changes in the Meekel sinus.