4,4-bis[2-(4-methoxyphenyl)prop-2-en-1-yl]-3-phenylisoxazol-5(4H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4,4-bis[2-(4-methoxyphenyl)prop-2-en-1-yl]-3-phenylisoxazol-5(4H)-one
• 英文别名: 4,4-Bis[2-(4-methoxyphenyl)prop-2-enyl]-3-phenyl-1,2-oxazol-5-one；4,4-bis[2-(4-methoxyphenyl)prop-2-enyl]-3-phenyl-1,2-oxazol-5-one
• 化学式: C₂₉H₂₇NO₄
• 分子量: 453.538
• InChiKey: YZQKQOIVBDNSGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  丙二烯 、 4-碘苯甲醚 、 3-苯基-5-异噁唑酮 在 palladium diacetate 三(2-呋喃基)膦 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 130.0 ℃ 、100.0 kPa 条件下， 反应 25.0h， 以53%的产率得到4,4-bis[2-(4-methoxyphenyl)prop-2-en-1-yl]-3-phenylisoxazol-5(4H)-one
  参考文献：
  名称：

  Pd(0) catalyzed three–five-component C-2-arylallylation of active methylene heterocycles: pyrazolones, oxazolones, isoxazolones and N,N′-dimethylbarbituric acid

  摘要：

  A Pd(0) catalyzed three-five-component cascade involving an aryl iodide, allene and a heterocyclic pronucleophile is used to prepare 2-arylallyl derivatives (10-12 and 16-24) from 3-phenyl-5-isoxazolone (6) and 1-phenyl-3-methylpyrazolin-5-one (7) in moderate yield. Similar cascade allylation of masked amino acids 4-methyl-2-phenyl-4H-oxazol-5-one (8a), 4-benzyl-2-phenyl-4H-oxazol-5-one (8b) and 4-isopropyl-2-phenyl-4H-oxazol-5-one (8c) gave analogous products (25-37) in good yield. N,N-Dimethylbarbiturates (38-49) are similarly prepared from N,N-dimethylbarbituric acid (9) in excellent yield. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.04.090

文献信息

• Pd(0) catalyzed three–five-component C-2-arylallylation of active methylene heterocycles: pyrazolones, oxazolones, isoxazolones and N,N′-dimethylbarbituric acid
  作者：Ronald Grigg、M. Ruhul A. Sarkar、Abirami Thayaparan、Visuvanathar Sridharan、Colin W.G. Fishwick

  DOI：10.1016/j.tet.2007.04.090

  日期：2007.7

  A Pd(0) catalyzed three-five-component cascade involving an aryl iodide, allene and a heterocyclic pronucleophile is used to prepare 2-arylallyl derivatives (10-12 and 16-24) from 3-phenyl-5-isoxazolone (6) and 1-phenyl-3-methylpyrazolin-5-one (7) in moderate yield. Similar cascade allylation of masked amino acids 4-methyl-2-phenyl-4H-oxazol-5-one (8a), 4-benzyl-2-phenyl-4H-oxazol-5-one (8b) and 4-isopropyl-2-phenyl-4H-oxazol-5-one (8c) gave analogous products (25-37) in good yield. N,N-Dimethylbarbiturates (38-49) are similarly prepared from N,N-dimethylbarbituric acid (9) in excellent yield. (C) 2007 Elsevier Ltd. All rights reserved.