1-azidohexanol

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 1-azidohexanol
• 英文别名: 1-Azidohexan-1-ol
• 化学式: C₆H₁₃N₃O
• 分子量: 143.189
• InChiKey: KXLXLSGGQYPWPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  34.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丁基环氧乙烷 在 sodium azide 、 ammonium cerium(IV) nitrate 作用下， 以 叔丁醇 为溶剂， 反应 2.0h， 生成 (+/-)-2-Azido-1-hexanol 、 1-azidohexanol
  参考文献：
  名称：

  Regioselective Azidolysis of Epoxides Catalyzed with Ce(IV)

  摘要：

  Regioselective conversion of epoxides to 1, 2-azidoalcohols was performed efficiently with sodium azide in t-butanol and in the presence of catalytic amounts of Ce(IV) as ceric ammonium nitrate (CAN).

  DOI：

  10.1080/00397919908085803

文献信息

• Synthetic Ligands For The Differentiation Of Closely Related Toxins And Pathogens
  申请人：Iyer Suri Saranathan

  公开号：US20090042816A1

  公开（公告）日：2009-02-12

  Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1 and Shiga toxin 2. Assay systems and methods for providing an assay are also provided for herein.

  本文揭示了合成配体化合物和区分志贺毒素1和志贺毒素2的方法。另一实施例包括用于区分志贺毒素1和志贺毒素2的试剂盒。还提供了用于提供测定的测定系统和方法。
• SYNHETIC IMMUNOGENIC GLYCOCONJUGATE FOR MELANOMA IMMUNOTHERAPY
  申请人：Azienda Ospedaliero-Universitaria Careggi

  公开号：EP2496266A1

  公开（公告）日：2012-09-12
• SYNTHETIC IMMUNOGENIC GLYCOCONJUGATE FOR MELANOMA IMMUNOTHERAPY
  申请人：Nativi Cristina

  公开号：US20120263735A1

  公开（公告）日：2012-10-18

  The present invention refers to compounds of formula (I) as useful melanoma vaccines' active ingredients. As a matter of fact, compounds of formula (I) are immunogenic artificial antigens, mimetics of GM3 and GM3 lactone, well known tumor associated antigens (TAAs). In addition, the present invention refers to specific antibodies for compounds of formula (I) which are able to bind to the TAAs. The hereinabove reported compounds and antibodies are therefore potentially useful respectively for the active and passive immunization against tumors overexpressing GM3 ganglioside, in a preferred embodiment melanoma and colon cancer, and for their diagnosis and prognosis.
• IMMUNOGENIC SYNTHETIC GLYCOCONJUGATE FOR THE IMMUNOTHERAPY OF MELANOMA
  申请人：AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI (Italian Hospital)

  公开号：US20140161806A1

  公开（公告）日：2014-06-12

  A specific antibody against a compound of formula (I) wherein X is O, NH, S, CH 2 ; L is a linker that is a divalent spacer; A is an adjuvant or carrier that is an immunogenic molecule or an immunogenic particle; and wherein bonds between linker and saccharide moiety and between linker and carrier are of covalent type; wherein the linker L presents a chemical structure suitable to space the saccharide moiety and the carrier by 7-30 atoms when the adjuvant/carrier A is a biomacromolecule or by 19-30 atoms when the adjuvant/carrier A is a metallic nanoparticle; wherein the carrier/adjuvant A can be selected among a macromolecule, a macrocycle, a dendrimer, a liposome, a nanoparticle, an oligosaccharide featuring from two to five monosaccharidic units or cells like dendritic cells.
• Synthetic Ligands for the Differentiation of Closely Related Toxins and Pathogens
  申请人：University of Cincinnati

  公开号：US20150309022A1

  公开（公告）日：2015-10-29

  Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1 and Shiga toxin 2. Assay systems and methods for providing an assay are also provided for herein.