5-[3-(4-cyclohexylpiperazin-1-yl)propyl]-5,6,7,8-tetrahydronaphthalen-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 5-[3-(4-cyclohexylpiperazin-1-yl)propyl]-5,6,7,8-tetrahydronaphthalen-1-ol
• 英文别名: 5-[3-(4-Cyclohexyl-piperazin-1-yl)-propyl]-5,6,7,8-tetrahydro-naphthalen-1-ol
• 化学式: C₂₃H₃₆N₂O
• 分子量: 356.552
• InChiKey: UDBYCFZOJXFYCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-[3-(4-cyclohexylpiperazin-1-yl)propyl]-5,6,7,8-tetrahydronaphthalen-1-ol 在 potassium carbonate 、 一水合肼 、 sodium iodide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 31.0h， 生成 10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine
  参考文献：
  名称：

  Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties

  摘要：

  Despite the promising potentials of sigma(2) receptors in cancer therapy and diagnosis, there are still ambiguities related to the nature and physiological role of the a, protein. With the aim of providing potent and reliable tools to be used in sigma(2) receptor research, we developed a novel series of fluorescent sigma(2) ligands on the basis of our previous work, where high-affinity sigma(2) ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl]piperazine (1, PB28) was used as the pharmacophore. Compared to the previous compounds, these novel ligands displayed improved fluorescence and a, binding properties, were sigma(2)-specifically taken up by breast tumor cells, and were successfully employed in confocal microscopy. Compound 14, which was the best compromise between pharmacological and fluorescent properties, was successfully employed in flow cytometry, demonstrating its potential to be used as a tool in nonradioactive binding assays for studying the affinity of putative sigma(2) receptor ligands.

  DOI：

  10.1021/jm401874n
• 作为产物：
  描述：

  1-环己基-4-[3-(1,2,3,4-四氢-5-甲氧基-1-萘)丙基]-吡嗪 在 氢溴酸 作用下， 反应 12.0h， 生成 5-[3-(4-cyclohexylpiperazin-1-yl)propyl]-5,6,7,8-tetrahydronaphthalen-1-ol
  参考文献：
  名称：

  1-环己基哌嗪的4-（四氢-1-基）-和4-（萘-1-基）烷基衍生物作为具有激动剂sigma2活性的sigma受体配体。

  摘要：

  与sigma（2）受体配体1-cyclohexyl-4- [3-（5-甲氧基-1,2,3,4-四氢萘-1-基）丙基]哌嗪有关的几种1-cyclohexylpiperazine衍生物（33，K（i合成＝ 0.34nM）并在放射性配体结合测定中测试，以尝试结构亲和关系研究。中间烷基链长度和四氢化萘核上的甲氧基位置是变化的。还制备了一些萘类似物。在几乎所有化合物的sigma（2）受体结合物中都发现了高亲和力，其中一些化合物在亚纳摩尔范围内显示出K（i）值，但是发现了低sigma（2）/ sigma（1）选择性。具有三个（32和43）或五个亚甲基（39和46）的中间烷基链的化合物显示出最高的sigma（2）亲和力。发现具有四亚甲基链的化合物具有相当高的sigma（1）受体亲和力。36（K（i）= 0.036 nM）和45（K（i）= 0.22 nM）显示出良好的sigma（1）/ sigma（2）

  DOI：

  10.1021/jm031026e

文献信息

• 4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cyclohexylpiperazine as σ Receptor Ligands with Agonist σ₂ Activity
  作者：Francesco Berardi、Savina Ferorelli、Carmen Abate、Nicola Antonio Colabufo、Marialessandra Contino、Roberto Perrone、Vincenzo Tortorella

  DOI：10.1021/jm031026e

  日期：2004.4.1

  Several 1-cyclohexylpiperazine derivatives related to sigma(2) receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (33, K(i) = 0.34 nM) were synthesized and tested in radioligand binding assays, to attempt a structure-affinity relationship study. Intermediate alkyl chain length and methoxyl group position on the tetralin nucleus were varied. A few naphthalene

  与sigma（2）受体配体1-cyclohexyl-4- [3-（5-甲氧基-1,2,3,4-四氢萘-1-基）丙基]哌嗪有关的几种1-cyclohexylpiperazine衍生物（33，K（i合成＝ 0.34nM）并在放射性配体结合测定中测试，以尝试结构亲和关系研究。中间烷基链长度和四氢化萘核上的甲氧基位置是变化的。还制备了一些萘类似物。在几乎所有化合物的sigma（2）受体结合物中都发现了高亲和力，其中一些化合物在亚纳摩尔范围内显示出K（i）值，但是发现了低sigma（2）/ sigma（1）选择性。具有三个（32和43）或五个亚甲基（39和46）的中间烷基链的化合物显示出最高的sigma（2）亲和力。发现具有四亚甲基链的化合物具有相当高的sigma（1）受体亲和力。36（K（i）= 0.036 nM）和45（K（i）= 0.22 nM）显示出良好的sigma（1）/ sigma（2）
• Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells
  作者：Carmen Abate、John R. Hornick、Dirk Spitzer、William G. Hawkins、Mauro Niso、Roberto Perrone、Francesco Berardi

  DOI：10.1021/jm200591t

  日期：2011.8.25

  Fluorescent derivatives of sigma(2) high affinity ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine 1 (PB28) were synthesized. NBD or dansyl fluorescent tags were connected through a 5- or 6-atom linker in two diverse positions of 1 structure. Good sigma(2) affinities were obtained when the fluorescent tag was linked to 5-methoxytetralin nucleus replacing the methyl function. NBD-bearing compound 16 displayed high sigma(2) affinity (K(i) = 10.8 nM) and a optimal fluorescent properties. Its uptake in pancreatic tumor cells was evaluated by flow cytometry, showing that it partially occurs through endocytosis. In proliferating cells, the uptake was higher supporting that sigma(2) receptors are markers of cell proliferation and that the higher the proliferation is, the stronger the antiproliferative effect of sigma(2) agonists is. Colocalization of 16 with subcellular organelles was studied by confocal microscopy: the greatest was in endoplasmic reticulum and lysosomes. Fluorescent sigma(2) ligands show their potential in clarifying the mechanisms of action of sigma(2) receptors.
• Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties
  作者：Carmen Abate、Mauro Niso、Roberta Marottoli、Chiara Riganti、Dario Ghigo、Savina Ferorelli、Giulia Ossato、Roberto Perrone、Enza Lacivita、Don C. Lamb、Francesco Berardi

  DOI：10.1021/jm401874n

  日期：2014.4.24

  Despite the promising potentials of sigma(2) receptors in cancer therapy and diagnosis, there are still ambiguities related to the nature and physiological role of the a, protein. With the aim of providing potent and reliable tools to be used in sigma(2) receptor research, we developed a novel series of fluorescent sigma(2) ligands on the basis of our previous work, where high-affinity sigma(2) ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl]piperazine (1, PB28) was used as the pharmacophore. Compared to the previous compounds, these novel ligands displayed improved fluorescence and a, binding properties, were sigma(2)-specifically taken up by breast tumor cells, and were successfully employed in confocal microscopy. Compound 14, which was the best compromise between pharmacological and fluorescent properties, was successfully employed in flow cytometry, demonstrating its potential to be used as a tool in nonradioactive binding assays for studying the affinity of putative sigma(2) receptor ligands.
• Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors
  作者：Michael Kassiou、Robert F. Dannals、Xiang Liu、Dean F. Wong、Hayden T. Ravert、Ursula A. Scheffel

  DOI：10.1016/j.bmc.2005.03.039

  日期：2005.6

  The cyclohexyl piperazine I (1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-piperazine) has been shown to be a potent and selective sigma-2 receptor ligand. In the present study, we prepared [11 C]l by O-alkylation of the phenolic precursor 2 with [C-11]CH3I. [C-11]1 was obtained in a 29% non-decay corrected yield and specific activity of 9299 mCi/mu mol calculated at end-of-synthesis. The biodistribution of [C-11]1 in mouse brain demonstrated rapid and homogenous concentration in all brain structures, which included the cortex, thalamus, cerebellum and striatum. Co-administration of unlabelled 1 (1 mg/kg) or the sigma-2 selective ligand SM-21 (1 mg/kg) failed to show any significant inhibition of [C-11]1 uptake in the mouse brain. The evaluation of this radioligand in vivo in the mouse clearly indicates that it does not possess the required properties for studying sigma-2 receptors in the brain using PET. (c) 2005 Elsevier Ltd. All rights reserved.