3-(4-methoxyphenoxy)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-methoxyphenoxy)phenol
• 化学式: C₁₃H₁₂O₃
• 分子量: 216.236
• InChiKey: CEFBIIZQGVDFTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-methoxyphenoxy)phenol 在 吡啶 、 水 、 potassium carbonate 、 caesium carbonate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 11.0h， 生成 (1-benzyl-5-{3-[3-(4-methoxyphenoxy)phenoxy]propoxy}-1H-indol-3-yl)acetic acid
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor γ/δ agonists

  摘要：

  A series of alkoxy-3-indolylacetic acid analogs has been discovered as peroxisome proliferator-activated receptor (PPAR) agonists. Structure-activity relationship study indicated that PPAR alpha/gamma/delta activities were dependent on the nature of the hydrophobic group, the attachment position of the alkoxy linker to the indole ring, and N-alkylation of indole nitrogen. Some compounds presented significant PPAR gamma/delta activity and molecular modeling suggested their putative binding modes in the ligand binding domain of PPAR gamma. Of these, compound 51 was selected for in vivo study via an evaluation of microsomal stability in mouse and human liver. Compound 51 lowered the levels of fasting blood glucose, insulin, and HbA1c without gain in body weight in db/db mice. When compound 51 was treated, hepatic triglycerides level and the size of adipocytes in white adipose tissue of db/db mice were also reduced as opposed to treatment with rosiglitazone. Taken together, compound 51 shows high potential warranting further studies in models for diabetes and related metabolic disorders and may be in use as a chemical tool for the understanding of PPAR biology. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.04.046
• 作为产物：
  描述：

  2-bromo-3-(4-methoxyphenoxy)cyclohex-2-en-1-one 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲苯 为溶剂， 以89 %的产率得到3-(4-methoxyphenoxy)phenol
  参考文献：
  名称：

  用于制备 3-芳氧基苯酚的经典 Ullmann 偶联的温和替代方法

  摘要：

  m eta -(Aryloxy)phenols 由 DBU 与 2-bromo-3-(aryloxy)cyclohex-2-en-1-ones 作用形成，后者很容易从 3-chlorocyclohex-2-en-1-ones 中获得两个步骤：用芳氧基取代氯（ArOH、K 2 CO 3、在 100 °C 下回流丙酮或 DMF）和溴化（NBS、DMF、室温）。该过程提供了一种温和的替代经典乌尔曼反应的方法，不需要任何金属催化剂。如果原始苯酚 (ArOH) 带有供电子基团，则该方法效果很好，但当取代基吸电子时，芳构化步骤 (DBU) 会伴随 ArO 单元的一些损失。

  DOI：

  10.1016/j.tet.2023.133264

文献信息

• Copolycarbonates having improved flowability
  申请人：Heuer Helmut-Werner

  公开号：US20050250915A1

  公开（公告）日：2005-11-10

  A copolycarbonate having improved flowability and processes for its preparation is disclosed. The molecular structure of the copolycarbonate includes at least one unit derived from at least one dihydroxy compound selected from the group consisting of compounds of formula (1) in which R 1 and R 2 each independently of the other represents hydrogen or linear or branched C 1 -C 10 -alkyl, and X represents O or S. preparation of polycarbonates.

  本发明揭示了一种具有改善流动性的共聚碳酸酯及其制备方法。该共聚碳酸酯的分子结构包括至少一个单元，该单元源自于选择自式（1）化合物的至少一种二羟基化合物，其中R1和R2分别独立地表示氢或线性或支链的C1-C10烷基，X表示O或S。制备聚碳酸酯。
• COPOLYCARBONATE MIT VERBESSERTER FLIESSFÄHIGKEIT
  申请人：Bayer MaterialScience AG

  公开号：EP1749043B1

  公开（公告）日：2008-07-30
• US7425358B2
  申请人：——

  公开号：US7425358B2

  公开（公告）日：2008-09-16