(+/-)-2-(2,6-dimethylphenoxymethyl)-1-methylpiperidine hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (+/-)-2-(2,6-dimethylphenoxymethyl)-1-methylpiperidine hydrochloride
• 英文别名: N-methyl-2-[(2,6-xyloxy)methyl]-piperidine hydrochloride；2-[(2,6-Dimethylphenoxy)methyl]-1-methylpiperidine;hydrochloride
• 化学式: C₁₅H₂₃NO*ClH
• 分子量: 269.815
• InChiKey: FAQQDPRPSGWSAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.25
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  13.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-)-2-(2,6-dimethylphenoxymethyl)-1-methylpiperidine hydrochloride 生成 2-[(2,6-dimethylcyclohexyl)oxymethyl]-1-methylpiperidine;hydrochloride
  参考文献：
  名称：

  ABERG, GUNNAR A. K.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-[(2,6-Dimethylphenoxy)methyl]piperidine;hydrochloride 生成 (+/-)-2-(2,6-dimethylphenoxymethyl)-1-methylpiperidine hydrochloride
  参考文献：
  名称：

  ABERG, GUNNAR A. K.

  摘要：

  DOI：

文献信息

• Membrane stabilizing phenoxy-piperidine compounds and pharmaceutical
  申请人：Aberg; Gunnar

  公开号：US04822778A1

  公开（公告）日：1989-04-18

  Compounds of the formula (I) ##STR1## optically active isomers thereof, and/or pharmaceutically acceptable acid addition salts thereof are disclosed, wherein R.sup.1 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, n-butyl, 2-hydroxyethyl, 3-hydroxypropyl and 4-hydroxybutyl, and wherein R is selected from the group consisting of ##STR2## in which R.sup.2, R.sup.3 R.sup.4 and R.sup.5 are the same or different and are each independently selected from the group consisting of hydrogen and methyl. Pharmaceutical preparations employing such compounds and method of using such compounds are also disclosed.

  公开了具有式(I)的化合物##STR1##及其光学活性异构体和/或药学上可接受的酸盐，其中R.sup.1选自由氢、甲基、乙基、正丙基、正丁基、2-羟乙基、3-羟丙基和4-羟丁基组成的群，R选自##STR2##中的组成，其中R.sup.2、R.sup.3、R.sup.4和R.sup.5相同或不同，且各自独立地选自由氢和甲基组成的群。还公开了使用这种化合物的药物制剂和使用这种化合物的方法。
• Membrane stabilizing compounds and pharmaceutical preparations and methods employing such compounds
  申请人：Aberg, Gunnar A.K.

  公开号：EP0200826A1

  公开（公告）日：1986-11-12

  This invention relates to novel substituted piperidines and pharmaceutical compositions containing these compounds, methods for their preparation and their use as membrane stabilizing agents. The novel substituted piperidines are compounds of the formula (I) optically active isomers thereof, and/or pharmaceutically acceptable acid addition salts thereof, wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, n-butyl, 2-hydroxyethyl, 3-hydroxyethylpropyl and 4-hydroxybutyl and wherein R is selected from the group consisting of in which R2, R3, R4 and R5 are the same or different and are each independently selected from the group consisting of hydrogen and methyl.

  本发明涉及新型取代的哌啶和含有这些化合物的药物组合物、其制备方法及其作为膜稳定剂的用途。 新型取代的哌啶是式 (I) 的化合物 其中 R1 选自由氢、甲基、乙基、正丙基、正丁基、2-羟乙基、3-羟乙基丙基和 4-羟丁基组成的组，R 选自由以下组成的组 其中 R2、R3、R4 和 R5 相同或不同，且各自独立地选自氢和甲基组成的组。
• Synthesis of Mexiletine Stereoisomers and Related Compounds via S_NAr Nucleophilic Substitution of a Cr(CO)₃-Complexed Aromatic Fluoride
  作者：David G. Loughhead、Lee A. Flippin、Robert J. Weikert

  DOI：10.1021/jo982287c

  日期：1999.4.1
• ABERG, GUNNAR A. K.
  作者：ABERG, GUNNAR A. K.

  DOI：——

  日期：——
• ——
  作者：ABERG G.、 EKENSTAM B. T.

  DOI：——

  日期：——