全氟-2,5,8,11-四甲基-3,6,9,12-四噁十五酸甲酯 | 133609-46-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 全氟-2,5,8,11-四甲基-3,6,9,12-四噁十五酸甲酯
• 中文别名: HFPO五聚体，甲酯
• 英文名称: Methyl perfluoro-2,5,8,11-tetramethyl-3,6,9,12-tetraoxapentadecanoate
• 英文别名: HFPO pentamer, methyl ester；methyl 2,3,3,3-tetrafluoro-2-[1,1,2,3,3,3-hexafluoro-2-[1,1,2,3,3,3-hexafluoro-2-[1,1,2,3,3,3-hexafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)propoxy]propoxy]propoxy]propanoate
• CAS: 133609-46-8
• 化学式: C₁₆H₃F₂₉O₆
• 分子量: 842.15
• InChiKey: XCSZRHBSQLYKOK-UHFFFAOYSA-N

物化性质

• 沸点：
  70-80°C 0,1mm
• 密度：
  1,74 g/cm3
• 闪点：
  >100°C

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  51
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  35

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R34
• 危险品运输编号：
  UN 3265

反应信息

• 作为反应物：
  描述：

  1,1,1-trimethylhydrazinium chloride 、 全氟-2,5,8,11-四甲基-3,6,9,12-四噁十五酸甲酯 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以82%的产率得到Trimethylamine(perfluoro-2,5,8,11-tetramethyl-3,6,9,12-tetraoxapentadecanoyl)imide
  参考文献：
  名称：

  Amine(polyfluoroalkoxyacyl)imide surfactants [1]

  摘要：

  Twenty-one examples (10a-d, 11a-I and 12a-e) of a new class of surfactants, the amine(polyfluoroalkoxyacyl)imides, were prepared by the reaction of esters containing polyfluoroalkoxy groups with tertiary alkylaminimides and hydroxyalkylaminimides. Included are five examples of difunctional aminacylimides that contain the hydrophilic portion of the molecule in the middle. These new surfactants are among the most potent known in their ability to form aqueous solutions with very low surface tensions and can be used to prepare stable emulsions of perfluorodecalin in water. Two new esters (ethyl perfluorooctyloxyacetate, 7, and ethyl 1H,1H-perfluorooctyloxyacetate, 9) used as intermediates to the surfactants were prepared by the alkylation of perfluoro- and 1H,1H-perfluorooctanol salts with ethyl bromoacetate. Other esters used in the preparation of the surfactants were derived from oligomers of hexafluoropropene oxide.

  DOI：

  10.1016/s0022-1139(00)80195-5

文献信息

• Novel aerosol formulation containing a polar fluorinated molecule
  申请人：——

  公开号：US20030194378A1

  公开（公告）日：2003-10-16

  The present invention relates to a stable pharmaceutical aerosol formulation intended for inhalation. The formulation contains an active substance, an aerosol propellant, a polar flurorinated molecule and an excipient. The preferred propellant is HFA 134a or HFA 227 or a mixture thereof.

  本发明涉及一种用于吸入的稳定药用气溶胶制剂。该制剂含有一种活性物质、一种气溶胶推进剂、一种极性氟化分子和一种赋形剂。优选的推进剂是 HFA 134a 或 HFA 227 或它们的混合物。
• NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE
  申请人：AstraZeneca AB

  公开号：EP1303258A1

  公开（公告）日：2003-04-23
• US9971306B2
  申请人：——

  公开号：US9971306B2

  公开（公告）日：2018-05-15
• [EN] NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE<br/>[FR] NOUVELLE PREPARATION EN AEROSOL CONTENANT UNE MOLECULE FLUOREE POLAIRE
  申请人：ASTRAZENECA AB

  公开号：WO2002003958A1

  公开（公告）日：2002-01-17

  The present invention relates to a stable pharmaceutical aerosol formulation intended for inhalation. The formulation contains an active substance, an aerosol propellant, a polar flurorinated molecule and an excipient. The preferred propellant is HFA 134a or HFA 227 or a mixture thereof.
• Amine(polyfluoroalkoxyacyl)imide surfactants [1]
  作者：Lisa Haywood、Sean McKee、W.J. Middleton

  DOI：10.1016/s0022-1139(00)80195-5

  日期：1991.3

  Twenty-one examples (10a-d, 11a-I and 12a-e) of a new class of surfactants, the amine(polyfluoroalkoxyacyl)imides, were prepared by the reaction of esters containing polyfluoroalkoxy groups with tertiary alkylaminimides and hydroxyalkylaminimides. Included are five examples of difunctional aminacylimides that contain the hydrophilic portion of the molecule in the middle. These new surfactants are among the most potent known in their ability to form aqueous solutions with very low surface tensions and can be used to prepare stable emulsions of perfluorodecalin in water. Two new esters (ethyl perfluorooctyloxyacetate, 7, and ethyl 1H,1H-perfluorooctyloxyacetate, 9) used as intermediates to the surfactants were prepared by the alkylation of perfluoro- and 1H,1H-perfluorooctanol salts with ethyl bromoacetate. Other esters used in the preparation of the surfactants were derived from oligomers of hexafluoropropene oxide.