A twofer: The title reaction sequence for cyclopropenes allows the preparation of aldehydes bearing α‐quaternary stereocenters in a one pot‐reaction from readily available starting materials. Through a diastereodivergent carbometalation reaction, both enantiomers of the corresponding aldehyde were obtained from the same cyclopropene derivative (see scheme).
麻烦的是:环
丙烯的标题反应序列允许从一应俱全的起始原料中一锅反应制备带有α-季立体中心的醛。通过非对映的
碳金属化反应,相应的醛的两种对映异构体均从相同的环
丙烯衍
生物获得(参见方案)。