3,4-dimethyl-2-(methylsulfanyl)pyridine

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3,4-dimethyl-2-(methylsulfanyl)pyridine
• 英文别名: 3,4-Dimethyl-2-methylsulfanylpyridine
• 化学式: C₈H₁₁NS
• 分子量: 153.248
• InChiKey: RZXFHVBETNAALQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,4-二甲基吡啶 、 二甲基二硫 在 正丁基锂 、 N,N-二甲基乙醇胺 作用下， 以 正己烷 、 四氢呋喃 为溶剂， 反应 2.0h， 以10%的产率得到3,4-dimethyl-2-(methylsulfanyl)pyridine
  参考文献：
  名称：

  4-甲基吡啶和3,4-二甲基吡啶锂化过程中的侧链保留：轻松获得吡啶系列中的分子多样性

  摘要：

  4-甲基吡啶和3,4-二甲基吡啶的首次直接环选择性锂化是通过使用BuLi/LiDMAE聚集体来防止通常的侧链金属化实现的。通过环选择性顺序锂化在 C-2、C-6 和 C-5 位置引入了几种功能，为多取代吡啶构建块开辟了一条简单快速的途径。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

  DOI：

  10.1002/ejoc.200300243

文献信息

• 3-benzoyl-2,4,5-substituted pyridine derivatives or salts thereof and bactericides containing the same
  申请人：Nishide Hisaya

  公开号：US20060089390A1

  公开（公告）日：2006-04-27

  To provide 3-benzoyl-2,4,5-substituted pyridine derivatives or their salts, fungicides containing them, and intermediates for producing them. By providing a group of compounds comprising specific 3-benzoyl-2,4,5-substituted pyridine derivatives or their salts, or fungicides containing them, which have so-called rainfastness, whereby they are capable of exhibiting excellent effects even when crops have received rainfall after application of the chemicals, it becomes unnecessary to increase the number of applications or the dose of the chemicals by taking into consideration the rainfall after the application of the chemicals. Thus, it is possible to protect crops from disease injuries at a lower cost with less labor.

  提供3-苯甲酰基-2,4,5-取代吡啶衍生物或其盐，含有它们的杀菌剂以及用于生产它们的中间体。通过提供一组化合物，其中包括特定的3-苯甲酰基-2,4,5-取代吡啶衍生物或其盐，或含有它们的杀菌剂，这些化合物具有所谓的雨水稳定性，即使作物在化学品施用后遭受降雨，它们仍能展现出优异的效果，因此不必考虑化学品施用后的降雨增加化学品的施用次数或剂量。因此，可以以更低的成本和更少的劳动力保护作物免受病害的伤害。
• ARYL, HETEROARYL, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20220396563A1

  公开（公告）日：2022-12-15

  Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
• Side-Chain Retention During Lithiation of 4-Picoline and 3,4-Lutidine: Easy Access to Molecular Diversity in Pyridine Series
  作者：Thomas Kaminski、Philippe Gros、Yves Fort

  DOI：10.1002/ejoc.200300243

  日期：2003.10

  The first direct ring-selective lithiation of 4-picoline and 3,4-lutidine has been achieved through the use of BuLi/LiDMAE aggregates to prevent the usual side-chain metallation. Several functionalities have been introduced at the C-2, C-6 and C-5 positions by ring-selective sequential lithiation, opening a simple and fast route to polysubstituted pyridine building blocks. (© Wiley-VCH Verlag GmbH

  4-甲基吡啶和3,4-二甲基吡啶的首次直接环选择性锂化是通过使用BuLi/LiDMAE聚集体来防止通常的侧链金属化实现的。通过环选择性顺序锂化在 C-2、C-6 和 C-5 位置引入了几种功能，为多取代吡啶构建块开辟了一条简单快速的途径。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)