全缘千里光碱A | 32523-69-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 全缘千里光碱A
• 中文别名: 全缘千里光碱A(对)
• 英文名称: Tylophorinidine
• 英文别名: (13aS,14S)-3,7-dimethoxy-9,11,12,13,13a,14-hexahydrophenanthro[10,9-f]indolizine-6,14-diol
• CAS: 32523-69-6
• 化学式: C₂₂H₂₃NO₄
• 分子量: 365.4
• InChiKey: CMFIDYCYVJWPPL-PGRDOPGGSA-N

物化性质

• 熔点：
  2l3-4°C(dec.).
• 沸点：
  613.5±55.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHOD OF ISOLATING PHENANTHROINDOLIZIDINE ALKALOIDS FROM TYLOPHORA ATROFOLLICULATA WITH HIF-1 INHIBITORY ACTIVITY, COMPOSITIONS COMPRISING THEM AND THEIR USE
  申请人：Macau University of Science and Technology

  公开号：US20170312266A1

  公开（公告）日：2017-11-02

  A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about 22 phenanthroindolizidine alkaloids, including at least 11 new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional HIF-1 inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata . A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid to the subject.