3-phenyl-2-(o-tolyl)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-phenyl-2-(o-tolyl)pyridine
• 英文别名: 2-(2-Methylphenyl)-3-phenylpyridine
• 化学式: C₁₈H₁₅N
• 分子量: 245.324
• InChiKey: WTTSTLFDEQRYAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二苯基乙酮 在 叔丁基过氧化氢 、 silver hexafluoroantimonate 、 bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 silver fluoride 、 calcium oxide 作用下， 以 正壬烷 、 1,2-二氯乙烷 为溶剂， 反应 72.0h， 生成 3-phenyl-2-(o-tolyl)pyridine
  参考文献：
  名称：

  Iridium-catalyzed annulation between 1,2-diarylethanone and 3-aminopropanol toward site-specific 2,3-diaryl pyridines

  摘要：

  An iridium-catalyzed annulation between 1,2-diarylethanone and 3-aminopropanol was developed, leading to site specific 2,3-diarylpyridines in moderate yields. 3-Aminopropanol served as both a four-atom component and solvent during this procedure, releasing water as a clean by-product. The reaction may proceed with sequential imine formation, alcohol oxidation and intramolecular cyclization by Knoevenagel reaction. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.07.061

文献信息

• Iridium-catalyzed annulation between 1,2-diarylethanone and 3-aminopropanol toward site-specific 2,3-diaryl pyridines
  作者：Ning Gu、Miaochang Liu、Hepan Wang、Song Sun、Zhen Zhou、Weiming Hu、Jin-Tao Yu、Jiang Cheng

  DOI：10.1016/j.tetlet.2017.07.061

  日期：2017.8

  An iridium-catalyzed annulation between 1,2-diarylethanone and 3-aminopropanol was developed, leading to site specific 2,3-diarylpyridines in moderate yields. 3-Aminopropanol served as both a four-atom component and solvent during this procedure, releasing water as a clean by-product. The reaction may proceed with sequential imine formation, alcohol oxidation and intramolecular cyclization by Knoevenagel reaction. (C) 2017 Elsevier Ltd. All rights reserved.