2'-(4-dimethylamino-1,8-naphthalimido)-2'-deoxyuridine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2'-(4-dimethylamino-1,8-naphthalimido)-2'-deoxyuridine
• 英文别名: 6-(dimethylamino)-2-[(2R,3R,4S,5R)-2-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]benzo[de]isoquinoline-1,3-dione
• 化学式: C₂₃H₂₂N₄O₇
• 分子量: 466.45
• InChiKey: QQGCUNWGPQWXHM-CIVUBGFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-溴-1,8-萘二甲酸酐 在 N,N'-二环己基碳二亚胺 作用下， 以 异戊醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 38.5h， 生成 2'-(4-dimethylamino-1,8-naphthalimido)-2'-deoxyuridine
  参考文献：
  名称：

  New Fluorescent Conjugates of Uridine Nucleoside and Substituted 1,8-Naphthalimide: Synthesis, Weak Interactions and Solvent Effects on Spectra

  摘要：

  Novel fluorescent conjugates of uridine nucleoside and 4-dimethylamino-1,8-naphthalimide via linkage with different length, and their precursors were synthesized. Their spectroscopic properties were examined in ten different solvents. It was found that the spectroscopic properties for these conjugates are strongly dependent on polarity and hydrogen bonding ability of solvents. Their fluorescence spectra are also strongly influenced by intramolecular aromatic stacking and hydrogen bonding between the base or sugar moiety of the uridine nucleoside and naphthalimide moiety, which is controlled by the length of the linker.

  DOI：

  10.1007/s00706-002-0525-4