1,7-bis(4-cyanomethylphenoxy)heptane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,7-bis(4-cyanomethylphenoxy)heptane
• 英文别名: 1,7-Bis(4-cyanomethylphenoxy)heptane；2-[4-[7-[4-(cyanomethyl)phenoxy]heptoxy]phenyl]acetonitrile
• 化学式: C₂₃H₂₆N₂O₂
• 分子量: 362.472
• InChiKey: PPVLTZFHFONJRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  66
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  对甲基苯甲醛 、 1,7-bis(4-cyanomethylphenoxy)heptane 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  SYNTHESIS AND THERMAL PROPERTIES OF TWIN DIMERS CONTAINING CYANOSTILBENE GROUPS AS A MESOGENIC GROUP

  摘要：

  Twin dimers (TDs) with a different linking group (ester or ether) between the mesogenic group (cyanostilbene moiety) and the flexible spacer were synthesized to clarify the effect of the linking group on the mesomorphic properties. The sequence of the ester linking group and the position of the cyano group in the mesogenic core made an important contribution to the thermal properties of the twin dimers. A remarkable odd-even effect in the phase transition temperatures and entropy changes from a nematic phase to an isotropic fluid was observed for all the synthesized twin dimers.

  DOI：

  10.1080/15421400490425847
• 作为产物：
  描述：

  1,7-二溴庚烷 、 对羟基苯乙腈 在 sodium hydroxide 、 potassium carbonate 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 1,7-bis(4-cyanomethylphenoxy)heptane
  参考文献：
  名称：

  Amidine derivatives for treating amyloidosis

  摘要：

  本发明涉及在治疗与淀粉样蛋白相关的疾病中使用脲类化合物。特别地，本发明涉及一种治疗或预防受试者淀粉样蛋白相关疾病的方法，包括向受试者施用治疗量的脲类化合物。本发明中可用的化合物包括以下公式的化合物，当施用时，可减少或抑制淀粉样蛋白纤维形成、神经退行性或细胞毒性：1

  公开号：

  US20040006092A1

文献信息

• Amidine derivatives for treating amyloidosis
  申请人：Neurochem, Inc.

  公开号：US20040006092A1

  公开（公告）日：2004-01-08

  The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited: 1

  本发明涉及在治疗与淀粉样蛋白相关的疾病中使用脲类化合物。特别地，本发明涉及一种治疗或预防受试者淀粉样蛋白相关疾病的方法，包括向受试者施用治疗量的脲类化合物。本发明中可用的化合物包括以下公式的化合物，当施用时，可减少或抑制淀粉样蛋白纤维形成、神经退行性或细胞毒性：1
• AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS
  申请人：Neurochem (International) Limited

  公开号：EP1420773A1

  公开（公告）日：2004-05-26
• [EN] AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS<br/>[FR] DERIVES D'AMIDINE DESTINES AU TRAITEMENT DE L'AMYLOSE
  申请人：NEUROCHEM INC

  公开号：WO2003017994A1

  公开（公告）日：2003-03-06

  The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula (X), such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited.
• [EN] AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS<br/>[FR] DERIVES D'AMIDINE POUR LE TRAITEMENT DES AMYLOSES
  申请人：UNIV NORTH CAROLINA

  公开号：WO2003103598A2

  公开（公告）日：2003-12-18

  The present invention relates to the use of amidine compounds in the treatment of amyloid related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formulae, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited. Formula I, Formula II, Formula III.
• SYNTHESIS AND THERMAL PROPERTIES OF TWIN DIMERS CONTAINING CYANOSTILBENE GROUPS AS A MESOGENIC GROUP
  作者：H. Aoki、T. Mihara、N. Koide

  DOI：10.1080/15421400490425847

  日期：2004.1.1

  Twin dimers (TDs) with a different linking group (ester or ether) between the mesogenic group (cyanostilbene moiety) and the flexible spacer were synthesized to clarify the effect of the linking group on the mesomorphic properties. The sequence of the ester linking group and the position of the cyano group in the mesogenic core made an important contribution to the thermal properties of the twin dimers. A remarkable odd-even effect in the phase transition temperatures and entropy changes from a nematic phase to an isotropic fluid was observed for all the synthesized twin dimers.