3-hydroxypropionic acid ammonium salt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3-hydroxypropionic acid ammonium salt
• 英文别名: Ammonium 3-hydroxypropionate；azanium;3-hydroxypropanoate
• 化学式: C₃H₅O₃*H₄N
• 分子量: 107.109
• InChiKey: WWDGNTXLUFFDRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.51
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxypropionic acid ammonium salt 在 Ti-0720 作用下， 以 水 为溶剂， 生成 丙烯酰胺
  参考文献：
  名称：

  Method for conversion of beta-hydroxy carbonyl compounds

  摘要：

  揭示了一种将β-羟基羰基化合物的盐转化为有用的转化产物的过程，包括α，β-不饱和羰基化合物和/或α，β-不饱和羰基化合物的盐。这些转化产物可以用作原料或最终用途的化学品。

  公开号：

  US20070219391A1
• 作为产物：
  描述：

  3-羟基丙酰胺 在 immobilized C_. testosteroni 5-MGAM-4D (ATCC 55744) amidase 作用下， 以 acetate buffer 为溶剂， 生成 3-hydroxypropionic acid ammonium salt
  参考文献：
  名称：

  3-羟基链烷腈生物催化水解为3-羟基链烷酸

  摘要：

  具有腈水合酶和酰胺酶活性的组合的微生物催化剂具有比微生物腈水解酶催化剂更高的水解3-羟基链烯腈的比活性。Comamonas testosteroni 22–1，Dietzia sp.。ADL1和Comamonas睾丸激素5-MGAM-4D腈水合酶/酰胺酶生物催化剂各自将3-羟基戊腈水解为3-羟基戊酸（以铵盐的形式），产率为99-100％，但是在催化剂循环的连续分批反应中，固定有藻酸盐的C睾丸激素5-MGAM-4D具有出色的酶稳定性和体积生产率。在一系列连续的85次间歇反应中，使用生物催化剂进行循环以生产1.0 M 3-羟基戊酸，最终反应中回收的腈水合酶和酰胺酶活性分别为初始活性的29％和40％。该系列反应的催化剂生产率为670 g 3-羟基戊酸/ g干细胞重量（50 g 3-羟基戊酸/ g生物催化剂珠），该系列中初始反应的体积生产率为44 g 3-HVA /升/小时 用藻酸盐固定的睾丸梭菌

  DOI：

  10.1002/adsc.200303007

文献信息

• Process for converting a hydroxycarboxylic acid, or salts thereof, to an unsaturated carboxylic acid and/or its esters
  申请人：Bogan, JR. Leonard Edward

  公开号：US20090076297A1

  公开（公告）日：2009-03-19

  A process for converting a salt of a hydroxycarboxylic acid to an unsaturated carboxylic acid, or esters thereof. The process involves converting an ammonium salt of a hydroxycarboxylic acid in aqueous solution to a corresponding hydroxycarboxylic acid and ammonium cation in aqueous solution; and separating the ammonium cation from the aqueous solution, leaving the hydroxycarboxylic acid in aqueous solution. The converting and separating steps may be accomplished by employing a hydrophobic acid or an acid ion exchange resin, each of which must have an acid dissociation constant, i.e., pK a , at least 0.5 less that that of the salt of the hydroxycarboxylic acid. Where a hydrophobic acid is used, it must be immiscible in water, and its salt must also be immiscible in water, and the resulting multi-phase solution comprises an aqueous phase comprising the corresponding hydroxycarboxylic acid, as well as a non-aqueous phase comprising a neutralized acid. Alternatively, where the ion exchange resin is used, the aqueous solution of the ammonium salt of a hydroxycarboxylic acid is contacted with the resin, thereby converting the salt to a hydroxycarboxylic acid and capturing the ammonium cations on the resin. In either case, the aqueous solution is treated, such as by heating, to separate and recover the hydroxycarboxylic acid. The non-aqueous phase or resin is treated to separate and recover ammonia useful for preparing additional ammonium salt of a hydroxycarboxylic acid.

  将羟基羧酸盐转化为不饱和羧酸或其酯的过程。该过程涉及将水溶液中的羟基羧酸铵盐转化为相应的水溶液中的羟基羧酸和铵阳离子；并将铵阳离子从水溶液中分离出去，留下水溶液中的羟基羧酸。转化和分离步骤可以通过使用疏水酸或酸离子交换树脂来实现，这两者必须具有酸解离常数，即pKa，至少比羟基羧酸盐的pKa小0.5。如果使用疏水酸，则必须与水不相溶，其盐也必须与水不相溶，所得的多相溶液包括含有相应羟基羧酸的水相，以及含有中和酸的非水相。或者，如果使用离子交换树脂，则将羟基羧酸铵盐的水溶液与树脂接触，从而将盐转化为羟基羧酸，并在树脂上捕获铵阳离子。在任一情况下，水溶液经过处理，如加热，以分离和回收羟基羧酸。非水相或树脂经过处理以分离和回收氨，用于制备额外的羟基羧酸铵盐。
• Method and apparatus for conversion of beta-hydroxy carbonyl compounds
  申请人：Zacher H. Alan

  公开号：US20070219390A1

  公开（公告）日：2007-09-20

  A process and apparatus are disclosed for conversion of β-hydroxy carbonyl compounds forming useful conversion products including, e.g., acrylic acid [CAS No. 79-10-7], acrylates, and acrylamide [CAS No. 79-06-01]. Conversion products find use, e.g., as feedstock and/or end-use chemicals.

  揭示了一种用于转化β-羟基羰基化合物以形成有用的转化产物的方法和装置，包括丙烯酸[CAS编号79-10-7]、丙烯酸酯和丙烯酰胺[CAS编号79-06-01]等。转化产物可用作原料和/或最终用途化学品。
• [EN] THERMAL SALT-SPLITTING OF (ALKYL)AMMONIUM 3-HYDROXYPROPIONATE<br/>[FR] DISSOCIATION THERMIQUE DES SELS DE 3-HYDROXYPROPIONATE D'(ALKYL)AMMONIUM
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2014151266A1

  公开（公告）日：2014-09-25

  A salt-splitting liquid (SSL) and a process that uses the SSL to "split" (alkyl)ammonium 3-hydroxypropionate salts into ammonia (or amines) and 3-hydroxypropionic acid (3-HP) that minimizes increases in viscosity and condensation reactions of the 3-HP. Converting (alkyl)ammonium 3-hydroxypropionate in an aqueous mixture to 3-HP includes admixing a polar aprotic organic solvent and an azeotroping solvent with the aqueous mixture. The azeotroping solvent forms an azeotrope mixture with water of the aqueous mixture. The SSL is heated to convert the (alkyl)ammonium 3-hydroxypropionate to 3-HP and ammonia, where heating produces a vapor phase containing at least water, ammonia and the azeotroping solvent. At least a portion of the water and the ammonia is removed from the vapor phase during the heating, and at least a portion of the azeotroping solvent is returned from the vapor phase back to SSL to maintain the azeotrope mixture with the water.

  一种盐分离液（SSL）和使用SSL的过程，用于将（烷基）氨基丙酸盐分解成氨（或胺）和3-羟基丙酸（3-HP），以最小化粘度增加和3-HP的缩合反应。将（烷基）氨基丙酸盐在水混合物中转化为3-HP包括将极性无电子对供体有机溶剂和共沸溶剂与水混合物混合。共沸溶剂与水形成共沸混合物。加热SSL将（烷基）氨基丙酸盐转化为3-HP和氨，加热产生至少含有水，氨和共沸溶剂的蒸汽相。在加热过程中，至少部分水和氨从蒸汽相中去除，并将至少部分共沸溶剂从蒸汽相返回到SSL中，以维持与水的共沸混合物。
• WO2008/42958
  申请人：——

  公开号：——

  公开（公告）日：——