3-[3-(trifluoromethoxy)phenyl]propionamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-[3-(trifluoromethoxy)phenyl]propionamide
• 英文别名: 3-[3-(Trifluoromethoxy)phenyl]propanamide
• 化学式: C₁₀H₁₀F₃NO₂
• 分子量: 233.19
• InChiKey: XJAPVYOXXSZBRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  间氯三氟甲氧基苯 、 丙烯酰胺 在 四甲基乙二胺 、 nickel dichloride 、 锌 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 60.0 ℃ 、1.07 kPa 条件下， 以41%的产率得到3-[3-(trifluoromethoxy)phenyl]propionamide
  参考文献：
  名称：

  METHOD FOR PRODUCING 3-ARYLPROPIONAMIDE COMPOUND AND 3-ARYLPROPIONIC ACID ESTER COMPOUND

  摘要：

  本发明提供了一种工业生产方法：制备具有杀虫效果的嘧啶化合物；2-[4-(三氟甲基)苯基]乙胺，它是嘧啶化合物的生产中间体；一种作为药用和农药中间体有用的苯乙胺化合物；以及进一步的作为苯乙胺化合物的生产中间体有用的3-芳基丙酰胺化合物和3-芳基丙酸酯化合物。通过在金属催化剂和还原剂存在下，将由式(1)表示的化合物（其中X代表氯原子或溴原子；Y代表可选地取代氟原子、氢原子、氟原子、氰基、烷基羰基、二烷基氨基基团等的烷基基团）与丙烯酰胺或丙烯酸酯反应，可以高效地并且工业化地在一步中生产3-芳基丙酰胺化合物或3-芳基丙酸酯化合物。

  公开号：

  US20200165209A1

文献信息

• [EN] 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS<br/>[FR] DERIVES DE 2-(6-AMINO-PYRIDINE-3-YL)-2-HYDROXYETHYLAMINE UTILISES COMME AGONISTES DES RECEPTEURS BETA 2-ADRENERGIQUES
  申请人：PFIZER LTD

  公开号：WO2004108676A1

  公开（公告）日：2004-12-16

  The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  该发明涉及公式（1）的化合物，以及用于制备、用于制备的中间体、含有和用途的过程。根据本发明的化合物在许多疾病、紊乱和状况中特别有用，特别是在炎症性、过敏性和呼吸系统疾病、紊乱和状况中。
• NOVEL COMPOUNDS ADVANTAGEOUS IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
  申请人：Pesyan Amir

  公开号：US20110046128A1

  公开（公告）日：2011-02-24

  A series of novel compounds showing anticonvulsant, chemical countermeasure(s), and analgesic activities is described. Such pharmaceutically active compounds may also show utility in the treatment of other central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, Parkinson's disease, spasticity, Alzheimer's disease, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), chronic neurodegenerative diseases (such as Alzheimer's disease and Huntington's disease), and/or traumatic brain and/or spinal cord injuries. Moreover, these/such compounds may also be useful in the treatment of status epilepticus and/or as chemical countermeasures.

  本文介绍了一系列新型化合物，具有抗惊厥、化学对抗剂和镇痛活性。这些药物活性化合物也可能在治疗其他中枢神经系统（“CNS”）疾病和障碍方面发挥作用，如焦虑、抑郁、失眠、偏头痛、精神分裂症、帕金森病、痉挛、阿尔茨海默病和双相情感障碍。此外，这些化合物还可以作为镇痛剂（例如，用于慢性或神经性疼痛的治疗）和作为神经保护剂，有助于治疗中风、慢性神经退行性疾病（如阿尔茨海默病和亨廷顿病）以及创伤性脑和/或脊髓损伤。此外，这些化合物还可以用于治疗癫痫持续状态和/或作为化学对抗剂。
• Method for producing 3-arylpropionamide compound and 3-arylpropionic acid ester compound
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US11028056B2

  公开（公告）日：2021-06-08

  The present invention provides a method for industrially producing: a pyrimidine compound having pest control efficacy; 2-[4-(trifluoromethyl)phenyl]ethylamine which is a production intermediate of the pyrimidine compound; a phenylethylamine compound useful as a pharmaceutical and agrochemical intermediate; and further a 3-arylpropionamide compound and a 3-arylpropionic acid ester compound useful as production intermediates of the phenylethylamine compound. The 3-arylpropionamide compound or the 3-arylpropionic acid ester compound can be efficiently and industrially produced in a single step by reacting a compound represented by formula (1) (wherein X represents a chlorine atom or a bromine atom; and Y represents an alkyl group optionally substituted with fluorine atom(s), a hydrogen atom, a fluorine atom, a cyano group, an alkylcarbonyl group, a dialkylamino group, or the like) with acrylamide or an acrylic acid ester in the presence of a metal catalyst and a reducing agent.

  本发明提供了一种工业化生产方法：一种具有害虫防治效果的嘧啶化合物；2-[4-(三氟甲基)苯基]乙胺，它是嘧啶化合物的生产中间体；一种苯基乙胺化合物，可用作医药和农用化学品中间体；以及一种3-芳基丙酰胺化合物和一种3-芳基丙酸酯化合物，可用作苯基乙胺化合物的生产中间体。3-arylpropionamide 化合物或 3-arylpropionic acid ester 化合物可通过式 (1) 所代表的化合物进行反应，在一个步骤中高效地工业化生产。 (其中 X 代表氯原子或溴原子；Y 代表任选被氟原子、氢原子、氟原子、氰基、烷基羰基、二烷基氨基等取代的烷基）与丙烯酰胺或丙烯酸酯在金属催化剂和还原剂存在下反应。
• 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS
  申请人：Pfizer Limited

  公开号：EP1633715A1

  公开（公告）日：2006-03-15
• [EN] NOVEL COMPOUNDS ADVANTAGEOUS IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS<br/>[FR] NOUVEAUX COMPOSÉS SERVANT À TRAITER LES MALADIES ET TROUBLES DU SYSTÈME NERVEUX CENTRAL
  申请人：AURIMMED PHARMA INC

  公开号：WO2009117515A2

  公开（公告）日：2009-09-24

  A series of novel compounds showing anticonvulsant activity is described. Such pharmaceutically active compounds may also show utility in the treatment of other central nervous system ("CNS") diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, Parkinson's disease, spasticity, Alzheimer's disease, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), chronic neurodegenerative diseases (such as Alzheimer's disease and Huntington's disease), and/or traumatic brain and/or spinal cord injuries. Moreover, these/such compounds may also be useful in the treatment of status epilepticus and/or as chemical countermeasures.