1-(2,4-dimethoxyphenyl)-5-phenyl-2-(3-phenylpropyl)pent-1-ene

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1-(2,4-dimethoxyphenyl)-5-phenyl-2-(3-phenylpropyl)pent-1-ene
• 英文别名: 2,4-Dimethoxy-1-[5-phenyl-2-(3-phenylpropyl)pent-1-enyl]benzene
• 化学式: C₂₈H₃₂O₂
• 分子量: 400.561
• InChiKey: KVGHLRHUCLCDEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2,2-trichloro-1-(2,4-dimethoxy-phenyl)-ethanol 在 吡啶 、 9-borabicyclo[3.3.1]nonane dimer 、 溶剂黄146 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 30.0h， 生成 1-(2,4-dimethoxyphenyl)-5-phenyl-2-(3-phenylpropyl)pent-1-ene
  参考文献：
  名称：

  Suzuki−Miyaura Cross-Coupling of 1,1-Dichloro-1-alkenes with 9-Alkyl-9-BBN

  摘要：

  We addressed an unexplored application of the Suzuki-Miyaura protocol to the cross-coupling of 1,1-dichloro-1-alkenes with 9-alkyl-9-BBN. The use of bisphosphine ligands with a large P-Pd-P bite angle allowed us to synthesize Z-chlorinated internal alkenes in good yields resulting from a selective monocoupling process, a recurrent challenge with 1,1-dichloro-1-alkenes. Moreover, these monochlorinated olefins could be further transformed providing stereospecifically trisubstituted olefins.

  DOI：

  10.1021/jo061908w

文献信息

• Suzuki−Miyaura Cross-Coupling of 1,1-Dichloro-1-alkenes with 9-Alkyl-9-BBN
  作者：Frédéric Liron、Céline Fosse、Alban Pernolet、Emmanuel Roulland

  DOI：10.1021/jo061908w

  日期：2007.3.1

  We addressed an unexplored application of the Suzuki-Miyaura protocol to the cross-coupling of 1,1-dichloro-1-alkenes with 9-alkyl-9-BBN. The use of bisphosphine ligands with a large P-Pd-P bite angle allowed us to synthesize Z-chlorinated internal alkenes in good yields resulting from a selective monocoupling process, a recurrent challenge with 1,1-dichloro-1-alkenes. Moreover, these monochlorinated olefins could be further transformed providing stereospecifically trisubstituted olefins.