4-(4-methoxyphenyl)-3-nitropyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(4-methoxyphenyl)-3-nitropyridine
• 英文别名: 3-nitro-4-(4-methoxyphenyl)pyridine
• 化学式: C₁₂H₁₀N₂O₃
• 分子量: 230.223
• InChiKey: RJFIBAKUXWMYHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  67.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-羟基-3-硝基吡啶 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 三(邻甲基苯基)磷 、 三氯氧磷 作用下， 以 1,4-二氧六环 为溶剂， 生成 4-(4-methoxyphenyl)-3-nitropyridine
  参考文献：
  名称：

  Cross Coupling Strategies towards the Synthesis of the Streptonigrin CD Moiety

  摘要：

  DOI：

  10.3987/com-98-8455

文献信息

• PHENYLPYRIDINE COMPOUND AND BACTERICIDAL COMPOSITION CONTAINING THE SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1541557A1

  公开（公告）日：2005-06-15

  A phenylpyridine compound represented by the formula has an excellent controlling activity against plant diseases: [, wherein, in the formula, R1, R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom and the like; R6 represents a hydrogen atom or a C1-C3 alkyl group; R7, R8 and R11 independently represent a hydrogen atom, a halogen atom and the like; R9 and R10 independently represent a hydroxyl group and the like; W1―W2=W3 ―W4 represents N―CH=CH―CH and the like; X represents an oxygen atom and the like; and Q represents a (C1-C6 alkoxy)methylene and the like].

  该式代表的苯基吡啶化合物对植物病害具有优异的控制活性: [其中，在该式中，R1、R2、R3、R4和R5分别代表氢原子、卤原子等; R6代表氢原子或C1-C3烷基; R7、R8和R11分别代表氢原子、卤原子等; R9和R10分别代表羟基等; W1―W2=W3―W4代表N―CH=CH―CH等; X代表氧原子等; Q代表(C1-C6烷氧基)亚甲基等]。
• Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
  申请人：——

  公开号：US20040110785A1

  公开（公告）日：2004-06-10

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

  这项发明提供了具有药物和生物影响特性的化合物，它们的药物组合物和使用方法。具体而言，该发明涉及吡啶并咪唑酮乙酰基哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染剂、免疫调节剂或HIV进入抑制剂结合使用。更具体地，本发明涉及治疗HIV和艾滋病。
• Phenylpyridine compound and fungicidal compostion containing the same
  申请人：Komori Takashi

  公开号：US20060041144A1

  公开（公告）日：2006-02-23

  A phenylpyridine compound represented by the formula has an excellent controlling activity against plant diseases: [, wherein, in the formula, R 1 , R 2 , R 3 , R 4 and R 5 independently represent a hydrogen atom, a halogen atom and the like; R 6 represents a hydrogen atom or a C1-C3 alkyl group; R 7 , R 8 and R 11 independently represent a hydrogen atom, a halogen atom and the like; R 9 and R 10 independently represent a hydroxyl group and the like; W 1 —W 2 ═W 3 —W 4 represents N—CH═CH—CH and the like; X represents an oxygen atom and the like; and Q represents a (C1-C6 alkoxy)methylene and the like].

  一种苯基吡啶化合物，其化学式如下，在该式中，R1、R2、R3、R4和R5独立地表示氢原子、卤素原子等；R6表示氢原子或C1-C3烷基；R7、R8和R11独立地表示氢原子、卤素原子等；R9和R10独立地表示羟基等；W1-W2═W3-W4表示N-CH═CH-CH等；X表示氧原子等；Q表示(C1-C6烷氧基)亚甲基等。该化合物对植物病害具有优异的控制活性。
• COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES
  申请人：Wang Tao

  公开号：US20080119480A1

  公开（公告）日：2008-05-22

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

  该发明提供了具有药物和生物影响性质的化合物，它们的制药组合物和使用方法。特别地，该发明涉及氮杂吲哌酮乙酰基哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染药物、免疫调节剂或HIV进入抑制剂联合使用。更具体地，本发明涉及治疗HIV和艾滋病。
• PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASE INHIBITORS
  申请人：Wang Tao

  公开号：US20100093752A1

  公开（公告）日：2010-04-15

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

  本发明提供了具有药物和生物影响性质的化合物，它们的药物组合物和使用方法。特别是，本发明涉及氮杂吲哚氧乙酰哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染药物、免疫调节剂或HIV进入抑制剂结合使用。更具体地，本发明涉及治疗HIV和艾滋病。