2-chloro-4-hydroxybenzenesulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-4-hydroxybenzenesulfonic acid
• 化学式: C₆H₅ClO₄S
• 分子量: 208.622
• InChiKey: RYVQCRHDUUSHQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氯苯酚 在 sodium hydrogensulfite 、 pyridinium chlorochromate 作用下， 以 neat (no solvent) 为溶剂， 100.0 ℃ 、200.0 kPa 条件下， 反应 0.03h， 生成 2-chloro-4-hydroxybenzenesulfonic acid
  参考文献：
  名称：

  Cornforth 和 Corey-Suggs 试剂作为在无溶剂和微波条件下使用 NaHSO3 磺化芳族和杂芳族化合物的有效催化剂

  摘要：

  摘要 Cornforth 和 Corey-Suggs 试剂重铬酸吡啶 (PDC) 和氯铬酸吡啶 (PCC) 作为有效催化剂，在室温下在乙腈水溶液中使用 NaHSO3 磺化芳族和杂芳族化合物 1-4 小时，而微波辅助反应需要在无溶剂条件下放置 1-4 分钟。这些观察表明微波辅助反应中的显着速率加速。这被解释为当微波通过反应介质时由原位产生的高温和高压引起的分子的大量活化。图形概要

  DOI：

  10.1080/10426507.2020.1782909

文献信息

• Sulfonation and sulfation in the reactions of the chloro- and dichlorophenols, 3-fluorophenol and (2,3-, 2,4- and 3,4-dichlorophenoxy)acetic acid with concentrated aqueous sulfuric acid and sulfur trioxide
  作者：Peter de Wit、Hans Cerfontain

  DOI：10.1002/recl.19881070303

  日期：——

  The chloro- and dichlorophenols have been sulfonated with sulfuric acid and with SO3 in aprotic solvents. In the sulfonations with concentrated aqueous sulfuric acid, the sulfonic acid isomer distribution is determined mainly by the ortho- and para-directing and activating effect of the hydroxy substituent; this is also the determining factor in the aprotic sulfonations using up to 1.0 equiv of SO3

  氯和二氯苯酚已在非质子传递溶剂中用硫酸和SO 3磺化。在用浓硫酸水溶液进行磺化反应中，磺酸异构体的分布主要取决于羟基取代基的邻位和对位和活化作用。这也是使用不超过1.0当量的SO 3的非质子磺化反应的决定因素。当使用大量的SO 3时，磺化异构体的分布越来越多地通过相应的苯基硫酸氢盐的额外磺化来确定，其中-OSO 3 H取代基是失活的，主要是对-（进而邻）指挥。
• WIT, PETER DE;CERFONTAIN, HANS, REC. TRAV. CHIM. PAYS-BAS, 107,(1988) N 3, 121-124
  作者：WIT, PETER DE、CERFONTAIN, HANS

  DOI：——

  日期：——
• WATER-SOLUBLE NEAR-INFRARED ABSORBING COLORING MATTERS AND AQUEOUS INKS CONTAINING SAME
  申请人：Hirota Koji

  公开号：US20110123784A1

  公开（公告）日：2011-05-26

  Coloring matters represented by general formula (1) or salts thereof are simply provided at a low cost as water-soluble coloring matters which exhibit absorption in the near-infrared region. Further, aqueous ink compositions which contain the coloring matters and have excellent storage stability are also provided. In general formula (1), Nc is optionally substituted naphthalocyanine; M is a metal oxide or the like; R 1 and R 2 are each independently hydrogen or the like; A is a crosslinking group; X and Y are each independently substituted arylamino or the like; k is more than 0 but up to 12 (on average); p is 0 to less than 12; the sum of k and p is more than 0 but up to 12; and any two or the three of R 1 , R 2 and A may be united to form a ring.
• US8404036B2
  申请人：——

  公开号：US8404036B2

  公开（公告）日：2013-03-26
• Cornforth and Corey-Suggs reagents as efficient catalysts for sulfonation of aromatic and heteroaromatic compounds using NaHSO₃under solvent free and microwave conditions
  作者：Touheeth Fatima、Govardhan Duguta、Venkanna Purugula、Hemanth Sriram Yelike、Chinna Rajanna Kamatala

  DOI：10.1080/10426507.2020.1782909

  日期：2020.12.1

  Pyridinium Dichromate (PDC) and Pyridinium Chlorochromate (PCC) were explored as efficient catalysts for sulfonation of aromatic and heteroaromatic compounds using NaHSO3 in aqueous acetonitrile medium at room temperature within 1–4 h, while microwave assisted reactions took place within 1–4 min under solvent-free conditions. These observations indicate significant rate accelerations in microwave assisted

  摘要 Cornforth 和 Corey-Suggs 试剂重铬酸吡啶 (PDC) 和氯铬酸吡啶 (PCC) 作为有效催化剂，在室温下在乙腈水溶液中使用 NaHSO3 磺化芳族和杂芳族化合物 1-4 小时，而微波辅助反应需要在无溶剂条件下放置 1-4 分钟。这些观察表明微波辅助反应中的显着速率加速。这被解释为当微波通过反应介质时由原位产生的高温和高压引起的分子的大量活化。图形概要