N-(2-(3-chlorophenoxy)-1-((3-chlorophenoxy)methyl)ethyl)methanesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(2-(3-chlorophenoxy)-1-((3-chlorophenoxy)methyl)ethyl)methanesulfonamide
• 英文别名: N-[1,3-bis(3-chlorophenoxy)propan-2-yl]methanesulfonamide
• 化学式: C₁₆H₁₇Cl₂NO₄S
• 分子量: 390.287
• InChiKey: IGLSXZBRFMEMKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  73
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-氯苯酚 、 2-(溴甲基)-1-(甲磺酰基)氮丙啶 在 silica gel 、 potassium carbonate 作用下， 以 水 为溶剂， 反应 16.0h， 以81%的产率得到N-(2-(3-chlorophenoxy)-1-((3-chlorophenoxy)methyl)ethyl)methanesulfonamide
  参考文献：
  名称：

  Ring opening of 2-(bromomethyl)-1-sulfonylaziridines towards 1,3-heteroatom substituted 2-aminopropane derivatives

  摘要：

  1,3-Heteroatom substituted 2-aminopropane derivatives have been prepared from 2-(bromomethyl)-1-sulfonylaziridines for the first time using sodium azide or different potassium phenoxides in water in the presence of silica gel. The applicability of 1-arenesulfonyl-2(bromomethyl)aziridines for the synthesis of functionalized sulfonamides has also been demonstrated towards different 1,3-dialkoxy-2(tosylamino)propanes and 1,3-dialkylthio-2-(tosylamino)propanes upon treatment with the appropriate sodium alkoxide or sodium alkylthiolate in the corresponding alcohol or in methanol, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.06.036

文献信息

• Ring opening of 2-(bromomethyl)-1-sulfonylaziridines towards 1,3-heteroatom substituted 2-aminopropane derivatives
  作者：Matthias D'hooghe、Mario Rottiers、Inge Kerkaert、Norbert De Kimpe

  DOI：10.1016/j.tet.2005.06.036

  日期：2005.9

  1,3-Heteroatom substituted 2-aminopropane derivatives have been prepared from 2-(bromomethyl)-1-sulfonylaziridines for the first time using sodium azide or different potassium phenoxides in water in the presence of silica gel. The applicability of 1-arenesulfonyl-2(bromomethyl)aziridines for the synthesis of functionalized sulfonamides has also been demonstrated towards different 1,3-dialkoxy-2(tosylamino)propanes and 1,3-dialkylthio-2-(tosylamino)propanes upon treatment with the appropriate sodium alkoxide or sodium alkylthiolate in the corresponding alcohol or in methanol, respectively. (c) 2005 Elsevier Ltd. All rights reserved.